Guidelines of Czech Association for Thrombosis and Haemostasis of the Czech Medical Association of J. E. Purkyně for safety treatment with new oral anticoagulants (NOAC) – dabigatran etexilate, apixaban and rivaroxaban

Česká verzia

Authors: Jan Kvasnička ¹; Miroslav Penka ²; Tomáš Kvasnička ¹; Jana Michalcová ²; Zuzana Kudrnová ¹; Ivana Malíková ¹
Authors place of work: Trombotické centrum Ústavu klinické biochemie a laboratorní diagnostiky 1. LF UK a VFN Praha, přednosta prof. MUDr. Tomáš Zima, DrSc., MBA ¹; Oddělení klinické hematologie FN Brno, primář prof. MUDr. Miroslav Penka, CSc. ²
Published in the journal: Vnitř Lék 2015; 61(6): 537-546
Category: Guidelines

Summary

There are presently new oral anticoagulants (NOAC) for prevention and the treatment of thromboembolic diseases and they are registered in CZ. It concerns of orally direct inhibitors of thrombin (dabigatran etexilate), inhibitors of factor Xa (apixaban, rivaroxaban), respectively, with advantage of some properties not being seen in „classical” anticoagulants. In the use of new anticoagulants, however, are some problems – such as laboratory monitoring in urgent situations of effective treatment and the absence of specific antidote – resolved. The text below brings indications, dosage of the drugs, their elimination, follow-up of efficacy of the treatment or risk of the bleeding as well as the therapy of bleeding complications.

Key words:
apixaban – dabigatran etexilate – NOAC – rivaroxaban

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