Faster Insulin Aspart – a new prandial insulin analogue

Česká verzia

Authors: MUDr. Milan Flekač, Ph.D.
Authors place of work: III. interní klinika endokrinologie a metabolizmu 1. LF UK a VFN v Praze
Published in the journal: Vnitř Lék 2017; 63(10): 697-702
Category: Reviews

Summary

Preventing postprandial blood glucose excursions is one of the most challenging aspects of achieving adequate control, especially in patients with better long-term compensation of diabetes. Contemporary prandial insulin analogues that have more favorable properties than human insulin in terms of accelerated absorption, earlier onset of action and shorter duration of action are still significantly slower than endogenous insulin in healthy individuals. Fast-acting insulin aspart (FIAsp – faster aspart) is insulin aspart enriched with two excipients, of which niacinamide is responsible for accelerating absorption after subcutaneous administration. The responsible mechanism is to accelerate the formation of monomers and to accelerate the transfer through capillary endothelial cells into the bloodstream. The article summarizes the most important outcomes of preclinical and clinical evaluation of new insulin and its relevance to practice.

Key words:
faster apart – FIAsp – Onset trial – pharmacodynamics – pharmacokinetics – postprandial glycaemia

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