Parathyroid cancer
Authors:
Ivana Ságová 1; Matej Stančík 1; Peter Kentoš 2; Dušan Pávai 2; Daniela Kantárová 1; Anton Vaňuga 2; Peter Vaňuga 2
Authors place of work:
I. Interná klinika JLF UK a UN Martin, Slovenská republika
1; Národný endokrinologický a diabetologický ústav, Ľubochňa, Slovenská republika
2
Published in the journal:
Vnitř Lék 2017; 63(2): 139-144
Category:
Case Reports
Summary
Parathyroid cancer is a rare endocrine malignancy, representing less than 1 % of all cases of primary hyperparathyroidism. The exact etiology of the disease remains unknown. Known risk factors include neck irradiation, end stage renal failure, genetic factors, particularly the the HPRT2/CDCT73 gene mutation. The clinical picture is often indolent, yet progressive with a trend of local invasion and metastasis formation in advanced disease. The clinical picture includes symptoms of severe and resistant hypercalcemia, requiring intensive therapy often with the need of dialysis. Radical surgery is the mainstay of the parathyroid cancer treatment. Chemotherapy and radiotherapy are generally ineffective. An early and correct diagnosis of parathyroid carcinoma significantly influences both morbidity and mortality.
Key words:
diagnosis – hyperparathyroidism – parathyroid cancer – treatment
Zdroje
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Štítky
Diabetology Endocrinology Internal medicineČlánok vyšiel v časopise
Internal Medicine
2017 Číslo 2
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