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Osteoporosis and quality of bone


Authors: Jan Štěpán
Authors place of work: Revmatologický ústav, Praha
Published in the journal: Vnitř Lék 2018; 64(2): 197-208
Category: Reviews

Summary

The risk of osteoporotic fracture is determined collectively by bone mineral density, bone mass, architecture and properties of the mineral and organic matrix composite. Changes in these distinct aspects of quality of bone with age, estrogen deficiency, diseases leading to increased risk of fracture and differential mode of action of antiresorptive and bone anabolic treatments have to be considered in clinical therapeutic strategies. In patients at high risk of low impact fracture, sequential therapy switching to antiresorptives after patients have an adequate response to 2 years teriparatide may be the optimal strategy of long term therapy.

Key words:
aging – bone quality – osteoporosis – prevention – therapy


Zdroje

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Štítky
Diabetology Endocrinology Internal medicine
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