#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
preLekára.sk / Journals / Internal Medicine / 2019 - 1

Non-celiac gluten/wheat sensitivity: still more questions than answers

Česká verzia

Authors: Iva Hoffmanová
Authors place of work: II. interní klinika 3. LF UK a FN Královské Vinohrady, Praha
Published in the journal: Vnitř Lék 2019; 65(1): 19-23
Category:

Summary

Non-celiac gluten/wheat sensitivity (NCG/WS) is a syndrome characterized by intestinal and extra-intestinal sym­ptoms elicited by gluten/wheat ingestion in the persons, who are not affected by celiac disease and wheat allergy. Due to the lack of established biomarkers, the diagnosis of NCG/WS is based on the clinical picture, and it is necessary to validate it in well-defined double-blind, placebo-controlled challenge (The Salerno Experts´ Criteria). In the article is discussed a current knowledge of NCG/WS in terms of pathogenesis, diagnosis and treatment.

Key words:

gluten – gluten-related disorders – non-celiac gluten/wheat sensitivity – wheat

Zdroje
  1. Hoffmanová I, Sánchez D. Non-celiac gluten sensitivity. Vnitř Lék 2015; 61(3): 219–227.
  2. Sapone A, Bai JC, Ciacci C et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012; 10: 13. Dostupné z DOI: <http://dx.doi.org/10.1186/1741–7015–10–13>.
  3. Junker Y, Zeissig S, Kim S et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med. 2012; 209(13): 2395–2408. Dostupné z DOI: <http://dx.doi.org/10.1084/jem.20102660>.
  4. Schuppan D, Pickert G, Ashfaq-Khan M et al. Non-celiac wheat sensitivity: differential diagnosis, triggers and implications. Best Pract Res Clin Gastroenterol 2015; 29(3):469–476. Dostupné z DOI: <http://dx.doi.org/10.1016/j.bpg.2015.04.002>.
  5. Gibson PR, Shepherd SJ. Food choice as a key management strategy for functional gastrointestinal symptoms. Am J Gastroenterol 2012; 107(5): 657–666; quiz 667. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2012.49>.
  6. Biesiekierski JR, Peters SL, Newnham ED et al. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 2013; 145(2): 320–328. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2013.04.051>.
  7. Catassi C, Elli L, Bonaz B et al. Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts‘ Criteria. Nutrients 2015; 7(6): 4966–4977. Dostupné z DOI: <http://dx.doi.org/10.3390/nu7064966>.
  8. Choung RS, Unalp-Arida A, Ruhl CE et al. Less Hidden Celiac Disease But Increased Gluten Avoidance Without a Diagnosis in the United States: Findings From the National Health and Nutrition Examination Surveys From 2009 to 2014. Mayo Clin Proc 2016. pii: S0025–6196(16)30634–6. Dostupné z DOI: <http://dx.doi.org/10.1016/j.mayocp.2016.10.012>.
  9. Schnedl WJ, Lackner S, Enko D et al. Non-celiac gluten sensitivity: people without celiac disease avoiding gluten-is it due to histamine intolerance? Inflamm Res 2018; 67(4):279–284. Dostupné z DOI: <http://dx.doi.org/10.1007/s00011–017–1117–4>.
  10. Fasano A, Sapone A, Zevallos V et al. Nonceliac gluten sensitivity. Gastroenterology 2015; 148(6): 1195–1204. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2014.12.049>.
  11. de Lorgeril M, Salen P. Gluten and wheat intolerance today: are modern wheat strains involved? Int J Food Sci Nutr 2014; 65(5): 577–581. Dostupné z DOI: <http://dx.doi.org/10.3109/09637486.2014.886185>.
  12. Valerii MC, Ricci C, Spisni E et al. Responses of peripheral blood mononucleated cells from non-celiac gluten sensitive patients to various cereal sources. Food Chem 2015; 176: 167–174. Dostupné z DOI: <http://dx.doi.org/10.1016/j.foodchem.2014.12.061>.
  13. Alvisi P, Fazio L de, Valerii MC et al. Responses of blood mononucleated cells and clinical outcome of non-celiac gluten sensitive pediatric patients to various cereal sources: a pilot study. Int J Food Sci Nutr 2017; 68(8): 1005–1012. Dostupné z DOI: <http://dx.doi.org/10.1080/09637486.2017.1315058>.
  14. Kasarda DD. Can an increase in celiac disease be attributed to an increase in the gluten content of wheat as a consequence of wheat breeding? J Agric Food Chem 2013; 61(6): 1155–1159. Dostupné z DOI: <http://dx.doi.org/10.1021/jf305122s>.
  15. Kucek LK, VeenstraLD, Amnuaycheewa P et al. A Grounded Guide to Gluten: How Modern Genotypes and Processing Impact Wheat Sensitivity. Comprehensive Rev Food Sci Food Saf 2015; 14(3): 285–302. Dostupné z DOI: <https://doi.org/10.1111/1541–4337.12129>.
  16. Volta U, Caio G, Karunaratne TB et al. Non-coeliac gluten/wheat sensitivity: advances in knowledge and relevant questions. Expert Rev Gastroenterol Hepatol 2017; 11(1): 9–18. Dostupné z DOI: <http://dx.doi.org/10.1080/17474124.2017.1260003
  17. Lionetti E, Pulvirenti A, Vallorani M et al. Re-challenge Studies in Non-celiac Gluten Sensitivity: A Systematic Review and Meta-Analysis. Front Physiol 2017; 8: 621.Dostupné z DOI: <http://dx.doi.org/10.3389/fphys.2017.00621>.
  18. Hollon J, Puppa EL, Greenwald B et al. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients 2015; 7(3): 1565–1576. Dostupné z DOI: <http://dx.doi.org/10.3390/nu7031565>.
  19. Uhde M, Ajamian M, Caio G et al. Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut 2016; 65(12): 1930–1937. Dostupné z DOI: <http://dx.doi.org/10.1136/gutjnl-2016–311964>.
  20. Volta U, Caio G, Tovoli F et al. Non-celiac gluten sensitivity: questions still to be answered despite increasing awareness. Cell Mol Immunol 2013; 10(5): 383–392. Dostupné z DOI: <http://dx.doi.org/10.1038/cmi.2013.28>.
  21. Sapone A, Lammers KM, Casolaro V et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med 2011; 9: 23. Dostupné z DOI: <http://dx.doi.org/10.1186/1741–7015–9-23>.
  22. Vazquez-Roque MI, Camilleri M, Smyrk T et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 2013; 144(5): 903–911. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2013.01.049>.
  23. Holmes G. Non coeliac gluten sensitivity. Gastroenterol Hepatol Bed Bench 2013; 6(3): 115–119.
  24. Brottveit M, Beitnes AR, Tollefsen S et al. Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity. Am J Gastroenterol 2013; 108(5):842–850. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2013.91>.
  25. Di Sabatino A, Giuffrida P, Fornasa G et al. Innate and adaptive immunity in self-reported nonceliac gluten sensitivity versus celiac disease. Dig Liver Dis 2016; 48(7): 745–752. Dostupné z DOI: <http://dx.doi.org/10.1016/j.dld.2016.03.024>.
  26. Gibson PR, Varney J, Malakar S et al. Food components and irritable bowel syndrome. Gastroenterology 2015; 148(6): 1158–1174. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2015.02.005>.
  27. Bohn L, Storsrud S, Liljebo T et al. Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial. Gastroenterology 2015; 149(6): 1399–1407. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2015.07.054>.
  28. Carroccio A, Mansueto P, Iacono G et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol 2012; 107(12): 1898–1906; quiz 1907. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2012.236>.
  29. Biesiekierski JR, Newnham ED, Irving PM et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011; 106(3): 508–514; quiz 515. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2010.487>.
  30. Volta U, Bardella MT, Calabro A et al. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med 2014; 12: 85. Dostupné z DOI: <http://dx.doi.org/10.1186/1741–7015–12–85>.
  31. Kabbani TA, Vanga RR, Leffler DA et al. Celiac disease or non-celiac gluten sensitivity? An approach to clinical differential diagnosis. Am J Gastroenterol 2014; 109(5): 741–746; quiz 747. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2014.41>.
  32. Carroccio A, D‘Alcamo A, Cavataio F et al. High Proportions of People With Nonceliac Wheat Sensitivity Have Autoimmune Disease or Antinuclear Antibodies. Gastroenterology 2015; 149(3): 596–603. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2015.05.040>.
  33. Paul SP, Hoghton M, Sandhu B. Limited role of HLA DQ2/8 genotyping in diagnosing coeliac disease. Scott Med J 2017; 62(1): 25–27. Dostupné z DOI: <http://dx.doi.org/10.1177/0036933016689008>.
  34. Catassi G, Lionetti E, Gatti S et al. The Low FODMAP Diet: Many Question Marks for a Catchy Acronym. Nutrients 2017; 9(3). pii: E292. Dostupné z DOI: <http://dx.doi.org/10.3390/nu9030292>.
  35. Barrett JS. How to institute the low-FODMAP diet. J Gastroenterol Hepatol 2017;32(Suppl 1): 8–10. Dostupné z DOI: <http://dx.doi.org/10.1111/jgh.13686>.
Štítky
Diabetology Endocrinology Internal medicine
Článek Prescription and dosage of RAAS inhibitors in patients with chronic heart failure in the FAR NHL registry
Článek Diagnostic pitfalls of celiac disease
Článek Potential possibility of phosphocreatine usage in internal medicine
Článek Direct oral anticoagulants in oncology in clinical praxis
Článek The combination of acromegaly and Klinefelter syndrome in one patient
Článok vyšiel v časopise

Internal Medicine

Číslo 1
2019 Číslo 1
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#