Chronic stress, mental discomfort, and depression increase the rates of infectious, autoimmune as well as malignant diseases

Česká verzia

Authors: Zdeněk Adam ¹; Zdeněk Král ¹; Jeroným Klimeš ²; Zdeněk Boleloucký ³; Luděk Pour ¹
Authors place of work: Interní hematologická a onkologická klinika LF MU a FN Brno, pracoviště Bohunice ¹; Soukromá psychologická ambulance – PhDr. Mgr. Jeroným Klimeš, Ph. D., Praha 9 – Újezd nad Lesy ²; Oddělení psychiatrie a psychoterapie Svitavské nemocnice, Svitavy ³
Published in the journal: Vnitř Lék 2020; 66(1): 34-38
Category:

Summary

Chronic stress and/or depression affect human health in all aspects of functioning. Chronic stress and/or depression reduce the functionality of immune defence. This review presents an overview of laboratory and clinical studies the aim of which was to evaluate the effect of stress on the development of malignant diseases as well as on that of infectious and autoimmune diseases. Numerous laboratory experiments have shown that chronic mental stress contributes to the development of tumours and has the potential to accelerate tumour growth. Many clinical studies have demonstrated that chronic mental stress increases the rates of cancer diseases (morbidity) as well as the death rates from them (mortality). When cancer disease is already present, marital status is one of the prognostic markers. Those who are widowed or divorced have shorter overall as well as tumour-specific survival rates than cohabiting persons. Many studies have analysed the effect of chronic stress, mental discomfort, and/or depression on the development of viral and bacterial infections. Most of these studies have confirmed a higher incidence of common viral and bacterial infections in individuals exposed to chronic stress or in those suffering from depression. Chronic stress also increases the rates or aggravates the course of autoimmune diseases. Chronic stress and depression states have a negative effect on bodily health. Hence, early therapeutic interventions are recommended because elimination of or alleviation from stress or depression during the course of bodily disease can reduce the number of somatic complications, thus reducing treatment costs. Based on the publications cited in the text, it can be concluded that “worrying brings on disease while contentment keeps it away.”

Keywords:

depression – Immunity – autoimmune disease – chronic stress – malignant disease

Zdroje

1. Chen H, Liu D, Guo L et al. Chronic psychological stress promotes lung metastatic colonization of circulating breast cancer cells by decorating a pre‑metastatic niche through activating β‑adrenergic signaling. J Pathol 2018; 244: 49–60.

2. Zhao L, Xu J, Liang F et al. Effect of Chronic Psychological Stress on Liver Metastasis of Colon Cancer in Mice. PLoS One 2015; 10: e0139978.

3. Krizanova O, Babula P, Pacak K Stress, catecholaminergic system and cancer. Stress 2016; 19: 419–428.

4. Flores IE, Sierra‑Fonseca JA, Davalos O et al. Stress alters the expression of cancer‑related genes in the prostate. BMC Cancer 2017; 17: 621–625.

5. Conti CM, Maccauro G, Fulcheri M. Psychological stress and cancer. International Journal immunopathology pharmacology 2011; 24: 1–5.

6. Becze E. Stress and inflammation combine to fuel cancer growth. ONS Connect. 2014; 29: 30–41.

7. Surman M, Janik ME. Stress and its molecular consequences in cancer progression. Postepy Hig Med Dosw (Online) 2017; 71: 485–499.

8. Sommershof A, Scheuermann L, Koerner J et al. Chronic stress suppresses anti‑tumor T(CD8+) responses and tumor regression following cancer immunotherapy in a mouse model of melanoma. Brain Behav Immun 2017; 65: 140–149.

9. Partecke LI, Speerforck S, Käding A et al. Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta‑adrenergic receptor blockade. Pancreatology 2016; 16: 423–433.

10. Shin KJ, Lee YJ, Yang X et al. Molecular Mechanisms Underlying Psychological Stress and Cancer. Curr Pharm Des 2016; 22: 2389–2402.

11. Repasky EA, Eng J, Hylander BL. Stress, metabolism and cancer: integrated pathways contributing to immune suppression. Cancer J 2015; 21: 97–103.

12. Reiche EM, Morimoto HK, Nunes SM. Stress and depression‑induced immune dysfunction: implications for the development and progression of cancer. Int Rev Psychia‑ try 2005; 17: 515–527.

13. Li P, Huang J, Wu H et al. Impact of lifestyle and psychological stress on the development of early onset breast cancer. Medicine (Baltimore) 2016; 95: e5529.

14. Schoemaker MJ, Jones ME, Wright LB et al. Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom. Breast Cancer Res 2016; 18: 72.

15. Cormanique TF, Almeida LE, Rech CA et al. Chronic psychological stress and its impact on the development of aggressive breast cancer. Einstein (Sao Paulo) 2015; 13: 352-356.

16. Andersen BL, Goyal NG, Weiss DM et al. Cells, cytokines, chemokines, and cancer stress: A biobehavioral study of patients with chronic lymphocytic leukemia. Cancer 2018; 124: 3240–3248.

17. Batty GD, Russ TC, Stamatakis E et al. Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies. Brit Med J 2017; 356: j108.

18. Özkan M, Yıldırım N, Disci R et al. Roles of Biopsychosocial Factors in the Development of Breast Cancer. Eur J Breast Health 2017; 13: 206–212.

19. Aizer AA, Chen MH, McCarthy EP et al. Marital status and survival in patients with cancer. J Clin Oncol 2013; 31: 3869–3876.

20. Wang F, Xie X, Yang X et al. The influence of marital status on the survival of patients with Hodgkin lymphoma. Oncotarget 2017; 8: 51016–51023.

21. Chen Z, Cui J, Dai W et al Influence of marital status on small intestinal adenocarcinoma survival: an analysis of the Surveillance Epidemiology, and End Results (SEER) database. Cancer Manag Res 2018; 10: 5667–5676.

22. Liu M, Li L, Yu W et al. Marriage is a dependent risk factor for mortality of colon adenocarcinoma without a time‑varying effect. Oncotarget 2017; 8: 20056–20066.

23. Li Y, Zhu MX, Qi SH. Marital status and survival in patients with renal cell carcinoma. Medicine (Baltimore) 2018; 97: e0385.

24. Coughlin SS. Anxiety and Depression: Linkages with Viral Diseases. Public Health 2012; 34: 92–94.

25. Liao CH, Chang CS, Muo CH et al. High prevalence of herpes zoster in patients with depression. J Clin Psychiatry 2015; 76: e1099–1104.

26. Irwin MR, Levin MJ, Carrillo C et al. Major depressive disorder and immunity to varicella‑zoster virus in the elderly. Brain Behav Immun 2011; 25: 759–766.

27. Rogers MA, Greene MT, Young VB et al. Depression, antidepressant medications, and risk of Clostridium difficile infection. BMC Med 2013; 11: 121.

28. Ugarte‑Gil C, Ruiz P, Zamudio C et al. Association of major depressive episode with negative outcomes of tuberculosis treatment. PLoS One 2013; 8: e69514.

29. Jagmag T, Tirant M, Lotti T. Link between cutaneous infection, stress and depression. J Biol Regul Homeost Agents 2017; 31: 1037–1041

30. Pedersen AF, Zachariae R, Jensen AB et al. Psychological stress predicts the risk of febrile episodes in cancer patients during chemotherapy. Psychother Psychosom 2009; 78: 258–260.

31. Sharif K, Watad A, Coplan L et al. The role of stress in the mosaic of autoimmunity: An overlooked association. Autoimmun Rev 2018; 17: 967–983.

32. Song H, Fang F, Tomasson G et al. Association of Stress‑Related Disorders With Sub‑ sequent Autoimmune Disease. JAMA 2018; 319: 2388–2400.

33. Andersson NW, Gustafsson LN, Okkels N et al. Depression and the risk of autoimmune disease: a nationally representative, prospective longitudinal study. Psychol Med 2015; 45: 3559–3569.

34. Marucha PT, Kiecolt‑Glaser JK. Mucosal wound healing is impaired by examination stress. Psychosom Med 1998; 60: 362–365.

35. Ebrecht M, Hextall J, Kirtley LG et al. Perceived stress and cortisol levels predict speed of wound healing in healthy male adult. Psychoneuroendocrinology 2004; 29: 798–809.

36. Ulrich‑Lai YM, Fulton S, Wilson M et al. Stress exposure, food intake and emotional state. Stress 2015; 18: 381–399.

37. Lawrence EM, Rogers RG, Wadsworth T. Happiness and longevity in the United States. Soc Sci Med 2015; 145: 115–119.

38. Maggi M, Corona G. Love protects lover’s life. J Sex Med 2011; 8: 931–935.

39. Johnson BT, Acabchuk RL. What are the keys to a longer, happier life? Answers from five decades of health psychology research. Soc Sci Med 2018; 196: 218–225.

40. Steptoe A, Wardle J. Enjoying life and living longer. Arch Intern Med 2012; 172: 273–275.