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Whipple disease – systemic disease with gastrointestinal manifestations


Authors: Leoš Chrudimský
Authors place of work: Patologicko-anatomické oddělení, Nemocnice Jihlava, p. o.
Published in the journal: Vnitř Lék 2021; 67(E-5): 3-8
Category: Review Articles

Summary

Whipple disease is rare, potentionally life-threatening disease with broad scale of possible symptoms and therefore wide differential diagnosis. Localized forms as well as systemic manifestations are possible. Etiological agent is bacteria Tropheryma whipplei. The most common manifestations include arthralgias, fever, diarrhea, abdominal pain, malabsorption syndrome and weight loss. In my article I present literature review and a case report of the pacient with relatively typical course of the disease.

Keywords:

malabsorption syndrome – Whipple disease – Tropheryma whipplei – intermitent fever – PAS positive macrophages – seronegative arthritis


Zdroje

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Štítky
Diabetology Endocrinology Internal medicine
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