Oral semaglutide – Rybelsus®, the first GLP-1 receptor agonist for oral use in clinical practice

Česká verzia

Authors: David Karásek
Authors place of work: III. Interní klinika – nefrologická, revmatologická a endokrinologická, LF UP a FN Olomouc
Published in the journal: Vnitř Lék 2022; 68(2): 89-95
Category: Main Topic

Summary

Glucagon like peptide-1 receptor agonists (GLP-1 RA) are potent antidiabetic drugs associated with significant weight loss and minimal risk of hypoglycemia. Semaglutide is a GLP-1 RA with a proven cardiovascular benefit. It is currently also available in oral form, which is especially suitable for the treatment of the initial phase of type 2 diabetes. However, it is also effective at later initiation of therapy, in different diabetic populations. The PIONEER 6 trial demonstrated cardiovascular safety of oral semaglutide, its administration was accompanied by a significant reduction in cardiovascular and overall mortality.

Keywords:

type 2 diabetes – glycated hemoglobin – cardiovascular benefit – oral semaglutide

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