Clinical experience with the use of newer antibiotics in internal medicine
Authors:
Pavla Paterová 1; Martina Novosadová 2
Authors place of work:
Ústav klinické mikrobiologie Fakultní nemocnice a Lékařská fakulta UK v Hradci Králové
1; Oddělení klinické farmacie, Nemocniční lékárna, Fakultní nemocnice Hradec Králové
2
Published in the journal:
Vnitř Lék 2022; 68(E-6): 10-14
Category:
Review Articles
doi:
https://doi.org/10.36290/vnl.2022.085
Summary
The alarming rise in antibiotic resistance between Gram-positive and Gram-negative bacteria makes maximum use of known and available antibiotics necessary. The aim of this work is to highlight some advantages and disadvantages of antibiotics that have appeared on the market in recent years, and share clinical experience with their use in internal medicine.
Flucloxacillin is an antibiotic with a significant antistaphylococcal effect, the most significant indications of the oral form are infections of the skin and soft tissues with the causative agent of Staphylococcus aureus and streptococci. The intravenous variant of flucloxacillin is an noninferior alternative to oxacillin and can be used in severe staphylococcal infections including infective endocarditis. Contributing to the treatment of uncomplicated urinary infections are the oral antibiotics mecilinam and fosfomycin. Their advantages are wide spectrum, good tolerability and possibility to use them in pregnant woman. Other antibiotics expand the treatment options for intravenous treatment of serious infections caused by multidrug-resistant bacteria. Ceftazidime/avibactam is effective for infections caused by Pseudomonas aeruginosa and enterobacteria including producers of broad-spectrum beta-lactamase ESBL, AmpC, KPC and OXA-48. The most important advantage of ceftolozane/ tazobactam is their antipseudomonal effect, is characterized by excellent clinical efficacy even against serious infections caused by Pseudomonas aeruginosa, including some multi-resistant strains.
Keywords:
antibiotic treatment – infectious diseases
Zdroje
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Štítky
Diabetology Endocrinology Internal medicineČlánok vyšiel v časopise
Internal Medicine
2022 Číslo E-6
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