Problems of Substitution Treatment in Opiate Dependence and Clinical Importance of Methadone
PROBLEMATIKA SUBSTITUČNÍ LÉČBY ZÁVISLOSTI NA OPIÁTECH A KLINICKÝ VÝZNAM METADONU
Je podán přehled o zkušenostech se substituční léčbou závislosti na opiátech. Léčba metadonem je nejčastější léčbou. Individuální denní dávka a dlouhodobá substituce jsou pro stabilizaci a motivaci pacientů v metadonovém programu žádoucí. Interakce metadonu s některými léky ovlivňuje metabolismus metadonu a vyžaduje změnu dávky metadonu a nesmí být opomíjena. Kromě metadonu existující i jiné farmakoterapie závislosti na opiátech (acetylmetadol, buprenorfin). V České republice byl v r. 1997 zahájen ve VFN Praha metadonový program. Význam metadonové substituční léčby je nepochybný a spočívá v zlepšování psychosociálního a zdravotního stavu toxikomanů a dává možnost k resocializaci a reintegraci do společnosti.
Klíčová slova:
toxikomanie, léčba závislosti na opiátech, metadon, substituční léčba, lékové interakce metadonu, metadonový program v České republice.
Authors:
H. Wilczek
Authors place of work:
III. interní klinika 1. LF UK a VFN, Praha
Published in the journal:
Čas. Lék. čes. 1998; : 725-728
Category:
Summary
The author presents a review of experience with substitution treatment in opiate dependence. Methadone treatment is most frequently used. An individual daily dose and long-term substitution are desirable for stabilization and motivation of patients included in the methadone programme. Interaction of methadone with some drugs affects the methadone metabolism and calls for a change of the methadone dose and must not be omitted. In addition to methadone there are also other types of pharmacotherapy of opiate dependence (acetylmethadol, buprenorphine). In the Czech Republic in 1997 in the General Faculty Hospital Prague the methadone programme was started. The importance of methadone substitution treatment is beyond doubt and involves improvement of the psychosocial and health status of addicts, gives an opportunity of resocialization and reintegration into society.
Key words:
drug addiction, treatment of opiate dependence, substitution treatment, drug interactions of methadone, methadone programme in the Czech Republic.
Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
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