Sixty Years of Antibiotics - Resistance: The Time Bomb for the 3rd Millenium
ŠESŤDESIAŤ ROKOV ANTIBIOTÍK - REZISTENCIA: ČASOVANÁ BOMBA PRE TRETIE TISÍCROČIE
Viac ako 50 rokov „antibiotickej éry“ prinieslo do klinického užívania celý rad antibiotík, špecifických i širokospektrálnych. Ich nadmerné užívanie však prinieslo a prináša vážne problémy - rezistenciu mnohých dôležitých baktérií, a tým aj postupnú stratu účinnosti týchto veľmi vzácnych substancií. Významnú, avšak negatívnu úlohu v tomto procese hrá transferabilita génov rezistence medzi baktériami, pričom bakteriálne kmene môžu prijímať celé bloky génov multirezistencie v treťom tisícročí musí byť racionalizácia užívania antibiotík, obmedzenie užívania niektorých zvlášť dôležitých preparátov a ďalšie opatrenia, vrátane dôsledného uplatňovania zásad nemocničnej hygieny a dodržiavania prísnych protiepidemických opatrení.
Klíčová slova:
antibiotiká, rezistencia, prenosná rezistencia.
Authors:
J. Blahová; K. Králiková; V. Krčméry st.
Authors place of work:
Ústav preventívnej a klinickej medicíny, Bratislava
Published in the journal:
Čas. Lék. čes. 2000; : 615-619
Category:
Summary
More then 50 years of antibiotic era has brought to clinical use many antibiotics with, specific and also with broad spectrum activity. Excessive use of antibiotics brought and brings serious problems - the resistance of many important bacteria and so the loss of effectivity of these scarce substances. Significant negative role in this process has the transferability of the resistance genes between bacteria. Bacterial strains are able to accept block of genes for multiresistance, exchange them inter species and spread to susceptible ones. There is an important task for the 3rd millenium to reduce the prevalence of the antibiotic resistance. Changes of the empiric treatment regiments (reduction in antibiotic use, antibiotic rotation, infection control, monitoring of resistance) and the strict hospital hygiene could help to solve the problems of antibiotic resistance in the future.
Key words:
antibiotics, resistance, transferable resistance.
Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
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- High-Dose Chemotherapy in the Treatment of Malignant Lymphoma in Children
- Resistance of the Haemopoietic Tumour Cells to the Cytotoxic Drugs. Part III.
- Sixty Years of Antibiotics - Resistance: The Time Bomb for the 3rd Millenium