Galectins in Squamous Cell Carcinomas of the Head and Neck Cancers
Authors:
Z. Čada 1,2
; J. Plzák 1,2,3; M. Chovanec 1,2,3
; B. Dvořánková 1,3; L. Lacina 1,3,4; P. Szabó 1; K. Smetana, Jr. 1,3; J. Betka 2
Authors place of work:
Karlova Univerzita, 1. lékařská fakulta, Anatomický ústav, Praha
1; Karlova Univerzita, 1. lékařská fakulta, Klinika otorinolaryngologie a chirurgie hlavy a krku FN Motol, Praha
2; Karlova Univerzita, 2. lékařská fakulta, Centrum buněčné terapie a tkáňových náhrad, Praha
3; Karlova Univerzita, 1. lékařská fakulta, Dermatovenerologická klinika VFN, Praha
4
Published in the journal:
Čas. Lék. čes. 2008; 147: 559-563
Category:
Review Article
Summary
Cancers of head and neck represents about 5% of all tumors. 80 to 90% of these tumors are constituted of squamous cell carcinomas. Despite a rapid progress in diagnostics and therapy the overall 5-year survival of this type of cancer is among the lowest of the major cancer types. This unfavourable situation needs the extensive research to found new markers to better characterize biological behavior of tumors as a rational background for more sophisticated therapeutic modalities. Among the most promising markers are endogenous lectins called galectins and their ligands. Especially galectin-1, -3 and -7 play a key role in pathology of squamous cell carcinomas.
Key words:
squamous cell carcinomas, lectins, galectins, prognostic markers.
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Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
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