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Spektrum požadovaných vyšetrení nukleárnej medicíny pri karcinóme prostaty po registrácii 18F fluorocholínu: dvojročné sledovanie v nemocnici Tenon


Authors: Soňa Balogová () 1,2;  Virginie Huchet () 1;  Laure Michaud () 1,3;  Khaldoun Kerrou () 1;  Fréderique Paycha () 1;  Valérie Nataf () 3,4;  Marika Vereb () 5,6;  Lucia Kaliská () 7;  Françoise Montravers () 1,3;  J.-N. Talbot () 1,3
Authors place of work: Médecine nucléaire, Hôpital Tenon, AP–HP, Paris, Francúzsko 1;  Klinika nukleárnej medicíny LF UK a OÚSA Bratislava, Slovensko 2;  Université Pierre-et-Marie-Curie, Paris, Francúzsko 3;  Radiopharmacie, Hôpital Tenon, AP–HP, 7 020 Paris, Francúzsko 4;  Klinikum Kassel Nuklearmedizin, Kassel, Nemecko 5;  Oddelenie nukleárnej medicíny, Reimanus s. r. o., Prešov, Slovensko 6;  INMM Košice & Agel diagnostics s. r. o., Pracovisko Banská Bystrica, Slovensko 7
Published in the journal: NuklMed 2012;1:42-47
Category: Original Article

Summary

Introduction:
The registration of a new PET radiopharmaceutical by medicines agencies is infrequent and it seemed interesting to follow its consequences on the prescription of alternative nuclear medicine (NM) examinations by the referring physicians. F-18 fluorocholine (FCH) was registered in France for localisation of bone metastases of prostate cancer (PC) on April 2nd 2010.

Methods:
A survey of the prescription of NM examinations in patients with PC was performed at hospital Tenon, covering 8 quarters since the registration of FCH. We provided bone scan, PET/CT with F-18-FDG (FDG), PET/CT with F-18-FNa (FNa) and PET/CT with FCH.

Results:
During that period of time, 721 NM examinations were performed in PC patients. Demand for FCH PET/CT grew rapidly, from 11 % of the NM examinations during the 1stquarter to 37 % during the 2nd quarter and 56 % during the 8th quarter. The total number of NM examinations requested for PC also grew over that period. Overall, the share of FCH PET/CT was 42 %, 27 % for bone PET/CT with fluoride FNa, 25 % for bone scintigraphy (BS). FDG PET/CT remained limited to few cases of castrate-resistant or metastatic PC (6 % of NM examinations). Examinations limited to the detection of bone metastases (FNa and BS) were predominantly demanded for initial staging while FCH was more frequently requested in case of occult recurrence, at lower PSA serum levels. Therapy monitoring and follow-up appeared to be promising settings requiring assessment; 19 % of NM examinations were prescribed in this context, same proportion as restaging prior to treatment resuming.

Conclusion:
The introduction of FCH resulted in a rapid demand for this PET/CT examination, in particular in case of occult recurrence, with an overall increase in PC referred to NM imaging.

Key Words:
prostate cancer, fluorocholine (FCH), fluoride (FNA), fluorodeoxyglucose (FDG), bone scintigraphy (BS), medical imaging prescription


Zdroje

1. Talbot JN, Gutman F, Huchet V, et al. Utilité clinique de la tomographie par émission de positons dans le cancer de la prostate. Presse Med 2007;36:1794-806

2. Kwee S, De Grado T, Talbot JN, et al. Cancer imaging with fluorine-18-labeled choline derivatives. Semin Nucl Med 2007;37:420-8

3. Huchet V, Kerrou K, Balogova S, et al. Tomographie par émission de positons et cancer de la prostate. Méd Nucl 2008;32:409-17

4. Huchet V, Kerrou K, Derhy S, et al. TEP/TDM à la fluorométhylcholine-(18F) dans l’imagerie de la récidive du cancer de la prostate: jalons pour un PHRC national. Méd Nucl 2007;31:338-44

5. Gutman F, Aflalo-Hazan V, Kerrou K, et al. 18F-choline PET/CT for initial staging of advanced prostate cancer. AJR Am J Roentgenol 2006;187:W618-21

6. Beheshti M, Vali R, Waldenberger P, et al. Detection of bone metastases in patients with prostate cancer by 18F fluorocholine and 18F fluoride PET-CT: a comparative study. Eur J Nucl Med Mol Imaging 2008;35:1766–74

7. Langsteger W, Balogova S, Huchet V, et al. Fluorocholine (18F) and sodium fluoride (18F) PET/CT in the detection of prostate cancer: prospective comparison of diagnostic performance determined by masked reading. Q J Nucl Med Mol Imaging 2011;55: 448-57

8. Talbot JN, Paycha F, Balogova S. Diagnosis of bone metastasis: recent comparative studies of imaging modalities. Q J Nucl Med Mol Imaging 2011;55:374-410

9. Beheshti M, Imamovic L, Broinger G, et al. 18F choline PET/CT in the preoperative staging of prostate cancer in patients with intermediate or high risk of extracapsular disease: a prospective study of 130 patients. Radiology 2010;254:925-33

10. Balogova S, Nataf V, Gutman F, et al. Récidive biologique de cancer de la prostate: intérêt de la TEP/TDM à la fluorocholine (18F) du corps entier. Méd Nucl 2010;34:540-5

11. Balogova S, Bumsel F, Kerrou K, et al. La fluorocholine(18F) a une utilité clinique dans le cancer de la prostate et le carcinome hépatocellulaire parfois chez le même malade, Méd Nucl 2010; 34:378-82

12. Mohler JL. NCCN Guidelines. Prostate cancer, version 4.2011. J Natl Compr Canc Netw 2011:Epub

13. Briganti A, Passoni N, Ferrari M, et al. When to perform bone scan in patients with newly diagnosed prostate cancer: external validation of the currently available guidelines and proposal of a novel risk stratification tool. Eur Urol 2010;57:551-8

14. Hillner BE, Siegel BA, Shields AF, et al. Relationship between cancer type and impact of PET and PET/CT on intended management: findings of the National Oncologic PET Registry. J Nucl Med 2008;49:1928–35

15. Kotzerke J, Oehme L, Lindner O, et al. Positron emission tomography 2008 in Germany - results of the query and current status. Nuklearmedizin 2010;49:58-64

16. Even-Sapir E, Metser U, Mishani E, et al. The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-Fluoride PET, and 18F-Fluoride PET/CT. J Nucl Med 2006; 47:287-97

17. Schmid DT, John H, Zweifel R, et al. Fluorocholine PET/CT in patients with prostate cancer: initial experience. Radiology 2005; 235:623-8

18. Gutman F, Thomassin J, Kerrou K et al. L’intérêt de la TEP/TDM à la fluorocholine-(18F) illustré par l’exemple. 2006;30:391-8

19. Cimitan M, Bortolus R, Morassut S et al. (18F)fluorocholine PET/CT imaging for the detection of recurrent prostate cancer at PSA relapse: experience in 100 consecutive patients. Eur J Nucl Med Mol Imaging 2006;33:1387-98

20. Heinisch M, Dirisamer A, Loidl W et al. Positron emission tomography/computed tomography with F-18-fluorocholine for restaging of prostate cancer patients: meaningful at PSA < 5 ng/ml? Mol Imaging Biol 2006;8:43-8

21. 21. Husarik, Miralbell R, Dubs M et al. Evaluation of (18F)-choline PET/CT for staging and restaging of prostate cancer. Eur J Nucl Med Mol Imaging 2008;35:253-63

22. Pelosi E, Arena V, Skanjeti A, et al. Role of whole-body 18F-choline PET/CT in disease detection in patients with biochemical relapse after radical treatment for prostate cancer. Radiol Med 2008;113:895-904

23. Steiner Ch, Vees H, Zaidi H, et al. Three-phase 18F-fluorocholine PET/CT in the evaluation of prostate cancer. Nuklearmedizin 2009;48:1-9

24. Graute V, Jansen N, Ubleis C, et al. Relationship between PSA kinetics and [(18)F]fluorocholine PET/CT detection rates of recurrence in patients with prostate cancer after total prostatectomy. Eur J Nucl Med Mol Imaging 2012;39:271-82

25. Huchet V , Gutman F, Kerrou K, et al. Evaluation of PSA velocity as a selection criterion for FCH PET/CT in patients with biological recurrence of prostate cancer. Eur J Nucl Med Mol Imaging 2007; 34(Suppl 2):S123

26. Price DT, Coleman RE, Liao RP, et al. Comparison of [18F]fluorocholine and [18F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer. J Urol 2002;168:273-80

27. McCarthy M, Siew T, Campbell A, et al. 18F-Fluoromethylcholine (FCH) PET imaging in patients with castration-resistant prostate cancer: prospective comparison with standard imaging. Eur J Nucl Med Mol Imaging 2011;38:14-22

28. Lavery HJ, Brajtbord JS, Levinson AW, et al. Unnecessary imaging for the staging of low-risk prostate cancer is common. Urology 2011;77:274-8

Štítky
Nuclear medicine Radiodiagnostics Radiotherapy
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