Comparison of whole body bone scintigraphy with levels of the serum concentration of human epididymal protein 4 in patients with malignant melanoma
Authors:
Jaroslav Weissensteiner 1; Eva Babušíková 2
Authors place of work:
Oddelenie nukleárnej medicíny, Nemocnica Poprad, a. s., SR
1; Ústav lekárskej biochémie, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave, SR
2
Published in the journal:
NuklMed 2015;4:8-12
Category:
Original Article
Summary
Introduction:
Melanoma is the most dangerous type of skin cancer and it is the leading cause of death from skin disease. The annual incidence has increased dramatically over the past few decades. The aim of this study was to correlate serum levels of the tumour marker human epididymal protein 4 (HE4) with the presence of bone metastases detected by whole-body bone scintigraphy in patients with malignant melanoma and to evaluate the importance of HE4 in the malignant melanoma diagnostics.
Material and methods:
We determined HE4 in serum from blood sample in 14 patients (4 men, 10 women) with malignant melanoma. The blood sample was took before radioactive tracer application in whole-body bone scintigraphy examination by using hybrid gamma camera SPECT/CT (single photon emission computed tomography/computed tomography). We compared the results with 10 individuals without malignant disease – control group.
Results:
Bone metastases using whole-body bone scintigraphy were detected in 5 cases (35.71 %), probably in 3 cases (21.43 %) and 6 patients (42.86 %) were without bone metastases. The concentration of HE4 was significantly higher in patients than in individuals of control group. Serum concentration of HE4 was higher above reference range only in one patient with melanoma. The concentrations of HE4 in patients were not different and dependent on grade of bone metastases.
Conclusion:
We observed that serum concentration of HE4 in patients with malignant melanoma was higher comparing to individuals of control group. The serum concentrations of HE4 were not correlated with finding on whole-body bone scintigraphy.
Key words:
melanoma, human epididymal protein 4, bone scintigraphy
Zdroje
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Štítky
Nuclear medicine Radiodiagnostics RadiotherapyČlánok vyšiel v časopise
Nuclear Medicine
2015 Číslo 1
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