#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
preLekára.sk / Journals / Nuclear Medicine / 2024 - 1

Evaluation of the distribution of dopamine D2 receptors with 123I-IBZM SPECT in laterali-zed and unilateral dystonias

Česká verzia

Authors: O. Lang 1,2,3;  L. Stejskal 4;  E. Růžička 4
Authors place of work: Kardiologická klinika 3. LF UK, Praha 10 1;  Oddělení nukleární medicíny PMCD s. r. o., Praha 2;  Oddělení nukleární medicíny Oblastní nemocnice Příbram 3;  Neurochirurgická a neuroonkologická klinika 1. LF UK a ÚVN, Praha, ČR 4
Published in the journal: NuklMed 2024;13:2-9
Category: Original Article

Summary

Introduction: Dystonia is a syndrome characterized by sustained muscle contractions frequently causing twisting and repetitive movements of the relative part of the body or abnormal postures. The precise pathophysiology of idiopathic dystonia is still unclear. Systematic investigation of involuntary movements characterized by constant laterality of posture and motion has not yet been done. The aim of our study was to determine the symmetry of the density of dopamine D2 receptors with 123I-IBZM SPECT in relation to the head rotation in patients suffering from unilateral or lateralized dystonia.

Methods: Seventeen patients with a clinical diagnosis of cervical dystonia participated in our study. There were 11 men and 6 women. The mean age was 48 years (25 to 64). Structural lesions of the brain were excluded by CT or MRI. The dopamine D2 receptor ligand used was 123I-IBZM. Imaging was performed with a dual-head SPECT gamma camera. We quantified the area as well as radioactivity accumulation within the striatum and its symmetry using five different methods. We assessed reliability by intraobserver and interobserver (2 readers) variability as well as methodological variability.

Results: From all the tested methods used for symmetry/asymmetry of 123I-IBZM uptake evaluation in striatum no one is more reproducible than the others including the most simple visual assessment. The correspondence with clinical findings was better for quantitative methods. In our study in 13 of 17 patients with (rotational) cervical dystonia the dopamine D2 receptors density predominated in the striatum ipsilateral to the rotation of the head.

Conclusions: The asymmetric accumulation of dopamine D2 receptors corresponding to the side of motor and postural asymmetry supports the view that the direction of circling behavior in animals and the direction of cervical dystonia in human beings might be predisposed.

Keywords:

idiopathic cervical dystonia – 123I-IBZM SPECT – D2 receptor asymmetry

Zdroje
  1. Hierholzer J, Cordes M, Schelosky L, et al. Dopamine D2 receptor Imaging with Iodine-123-Iodobenzamide SPECT in Idiopathic Rotational Troticollis. J Nucl Med. 1994;35:1921-1927
  2. Martin WR, Stoessl AJ, Palmer M, et al. PET scanning in dystonia. Adv Neurol. 1988;50:223-229
  3. Zeman W. Pathology of the torsion dystonias (dystonia musculorum deformans). Neurology. 1970;20:79-88
  4. Walker RH, Purohit DP, Good PF, et al. Severe generalized dystonia due to primary putaminal degeneration: case report and review of the literature. Mov Disord. 2002;17:576-584
  5. Vitek JL. Pathophysiology of dystonia: a neuronal model. Mov Disord. 2002;17(Suppl 3):S49-62
  6. Sawle GV, Leenders KL, Brooks  DJ, et al. Dopa-responsive dystonia: [18F]dopa positron emission tomography. Ann Neurol. 1991;30:24-30
  7. Naumann M, Pirker W, Reiners K, et al. Imaging the pre- and postsynaptic side of striatal dopaminergic synapses in idiopathic cervical dystonia: a SPECT study using [123I] epidepride and [123I] beta-CIT. Mov Disord. 1998;13:319-323
  8. Kung HF, Alavi A, Chang W, et al. In vivo SPECT imaging of CNS D-2 dopamine receptors: initial studies with iodine-123-IBZM in humans. J Nucl Med. 1990;31:573-579
  9. Costa DC, Verhoeff NPLG, Cullum ID, et al. In vivo characterisation of 3-iodo-6-methoxybenzamide 123I in humans. Eur J Nucl Med. 1990;16:813-816
  10. Brucke T, Wenger S, Asenbaum S, et al. Dopamine D2 receptor imaging and measurement with SPECT. Adv Neurol. 1993;60:494-500
  11. Baulieu JL, Ribeiro MJ, Levilion-Prunier C, et al. Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using 123I-iodolisuride SPECT. Nucl Med Commun. 1999;20:77-84
  12. Consky ES, Lang AE. Clinical assessments of patients with cervical dystonia. In: Jankovic J., Hallett M, eds. Therapy with botulinum toxin. New York: Marcel Dekker; 1994:211-237
  13. Seibyl JP, Woods SW, Zoghbi SS, et al. Dynamic SPECT imaging of dopamine D2 receptors in human subjects with iodine-123-IBZM. J Nucl Med. 1992;33:1964-1971
  14. Hertel A, Weppner M, Baas H, et al. Quantification of IBZM dopamine receptor SPET in de novo Parkinson patients before and during therapy. Nucl Med Commun. 1997;18:811-822
  15. Radau PE, Linke R, Slomka PJ, et al. Optimization of automated quantification of 123I-IBZM uptake in the striatum applied to parkinsonism. J Nucl Med. 2000;41:220-227
  16. Verhoeff NPLG, Kapucu O, Sokole-Busemann E, van Royen EA, Janssen AGM. Estimation of dopamine D2 receptor Binding Potential in the striatum with Iodine-123-IBZM SPECT: Technical and interobserver variability. J Nucl Med. 1993;34:2076-2084
  17. Ungerstedt U. Striatal dopamine-release by amphetamine in mice. Acta Physiol Scand. 1971;Suppl 367:49-68
  18. Mori K, Fujita Y, Shimabukuro  H, Handa H. Some considerations for treatment of spasmodic torticollis. Confin Neurol. 1975;37:265-269
  19. Mori K, Shimabukuro H, Yamashiro K, et al. Spasmodic head movements produced by destruction of unilateral ventromedial tegmentum in cats. Appl Neurophysiol. 1985;48:347-350
  20. Crossman AR, Sambrook MA. Experimental torticollis in the monkey produced by unilateral 6-hydroxydopamine brain lesions. Brain Res. 1978;149:498-502
  21. Jerussi TP, Glick SD. Amphetamine-induced rotation in rats without lesions. Neuropharmacology. 1974;13:283-286
  22. Zimmerberg B, Glick SD, Jerussi TP. Neurochemical correlate of a spatial preference in rats. Science. 1974;185:623-625
  23. Glick SD, Jerussi T, Waters DH, Green JP. Amphetamine-induced changes in striatal dopamine and acetylcholine levels and relationship to rotation (circling behavior) in rats. Biochem Pharmacol. 1974;23:3223-3225
  24. Glick SD, Jerussi TP, Zimmerberg B. Behavioral and neuropharmacological correlates of nigro-striatal asymmetry in rats. In: Harnad S (ed) Lateralization in the Nervous System. Academic Press, New York 1977
  25. Slater P, Blundell C. Effects of morphine on amphetamine-induced circling and striatal cyclic AMP in rats and mice. Neuropharmacol. 1979;18:705-708
  26. Reavill C. Metabolite involvement in bromocriptin-induced circling. J Pharm Pharmacol. 1980;32:728-784
  27. Korczyn AD, Eshel Y. Dopaminergic and non-dopaminergic circling activity of mice. Neuroscience. 1979;4:1085-1089
  28. Glick SD, Zimmerberg B, Greenstein S. Individual differences among mice in normal and amphetamine-enhanced locomotor activity: relationship to behavioral indices of striatal asymmetry. Brain Res. 1976;105:362-364
  29. Martinek Z, Dahme E. Spontaneous epilepsy in dogs: long-term studies on a group of genetically related animals. Zentralbl Veterinarmed A. 1977;24:353-371
  30. Perlmutter JS, Raichle ME. Regional cerebral blood flow in dystonia: an exploratory study. Adv Neurol. 1988;50:255-266
  31. Magyar-Lehmann S, Antonini A, Roelcke U, et al. Cerebral glucose metabolism in patients with spasmodic torticollis. Mov Disord. 1997;12:704-708
  32. Stoessl A, Martin WR, Clarc C, et al. PET studies of cerebral glucose metabolism in idiopathic torticollis. Neurology. 1986;36:653-657
  33. Chase TN, Tamminga CA, Burrows H. Positron emission tomographic studies of regional cerebral glucose metabolism in idiopathic dystonia. Adv Neurol.  1988;50:237-241
  34. Gilman S, Junck L, Young AB, et al. Cerebral metabolic activity in idiopathic dystonia studied with positron emission tomography. Adv Neurol. 1988;50:231-236
  35. Lang AE, Garnett ES, Firnau G, et al. Positron tomography in dystonia. Adv Neurol. 1988;50:249-253
  36. Leenders KL, Quinn N, Frackowiak RSJ, et al. Brain dopaminergic system studied in patients with dystonia using positron emission tomography. Adv Neurol. 1988;50:243-247
  37. Kunig G, Leenders KL, Antonini A, et al. D2 receptor binding in dopa-responsive dystonia. Ann Neurol. 1998;44:758-762
  38. Perlmutter JS, Stambuk MK, Markham J, et al. Decreased [18F]spiperone binding in putamen in dystonia. Adv Neurol. 1998;78:161-168
Štítky
Nuclear medicine Radiodiagnostics Radiotherapy
Článek Anti-ischemic effect of ACE inhibitor perindopril confirmed by myocardial perfusion ima-ging (MPI) in a patient with coronary artery disease
Článek Okénko do literatury
Článek ONM Hradec Králové
Článek Historický kvíz, Sonda do historie
Článek Nukleární medicína a RNDr. Vojtěch Ullmann, Ostrava
Článek Annual Congress of the European Association of Nuclear Medicine, Vídeň, Rakousko
Článek Editorial
Článok vyšiel v časopise

Nuclear Medicine

Číslo 1
2024 Číslo 1
Najčítanejšie v tomto čísle
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#