Results of Therapy in Early Stages of Glottic Larynx Cancer Summary
Authors:
P. Čelakovský; J. Vokurka; J. Růžička
Authors place of work:
Ušní, nosní a krční klinika LF UK a FN, Hradec Králové
přednosta doc. MUDr. J. Vokurka, CSc.
Published in the journal:
Otorinolaryngol Foniatr, 56, 2007, No. 1, pp. 3-6.
Category:
Original Article
Summary
The paper evaluates the results of therapy in patients with glottic larynx cancer in the stage T1 and T2. The cohort of 166 patients has been treated at our clinic in the years 1980 to 2000. The period of observation since operation was 3 to 23 years. The age of the patients was in the range of 35 and 91 years, the ratio of men and women was 12:1.
The relapse or persistence of larynx cancer after therapy was diagnosed in 41 patients, representing 25% of the cohort. Three years after the therapy 141 patients survived (85%) and 133 patients (80%) survived for the period of five years. Fourteen patients died in connection with larynx cancer, representing 8% of the cohort. Specific five-year survival in the whole cohort is therefore 92%. Among 41 patients treated for the relapse or persistence of the tumour, 27 proved to survive without sign of the tumour, representing 66% of this subgroup.
The relapse of larynx cancer occurred most often in tumours of the T2 stage, most rarely in T1a tumours, where the percentage of relapses proved to be 15%. The relapses occurred more frequently after actinotherapy than after surgery or after a combined therapy. In evaluating individual kinds of surgical treatment, relapse or persistence of tumour occurred more often after endolaryngeal treatment than after surgery from external approach.
Frequent relapses of the primary focus developed in cases, where a positive margin was proved by histology, in cases of low differentiation of the tumour and in patients with metastatic affection of lymphatic nodes.
Key words:
glottic larynx cancer.
Zdroje
1. Abadl, K., Profant, M., Doležal, P., Korch, J., Kišš, L.: Karcinóm hrtana u žien. Otorinolaryng. a Foniat. /Prague/, 52, 2003, s. 174-177.
2. Benninger, M.S., Gillen, J., Thieme, P., Jacobsen, B., Dragovich, J.: Factors, associated with recurrence and voice quality following radiation therapy fot T1 and T2 glottic carcinomas. Laryngoscope, 104, 1994, s. 294-298.
3. Blakeslee, D., Vaughan, C.W., Shapshay, S.M., Simpson, G.T., Strong, M.S.: Excisional biopsy in the selective management of T1 glottic cancer: a 3-year follow-up study. Laryngoscope, 94, 1984, s. 488-494.
4. Damm, M., Sittel, C., Streppel, M., Eckel, H.E.: Transoral CO2 laser for surgical management of glottic carcinoma in situ. Laryngoscope, 110, 2000, s. 215-221.
5. Fišerová, H., Betka, J., Kabelka, Z., Roubíčková, J., Kodet, R., Koutecký, J., Kavan, P.: Spinocelulární karcinom u jedenáctileté dívky. Otorinolaryng. a Foniat. /Prague/, 50, 2001, s. 123-126.
6. Jeřábek, L., Hybášek, I.: Místní šíření nádorů hrtanu a korelace klinické a histopatologické klasifikace. Otorinolaryng. a Foniat. /Prague/, 53, 2004, s. 143-146.
7. Jeřábek, L., Horáček, J., Hybášek I.: Analýza histopatologických nálezů resekátů hrtanu. Otorinolaryng. a Foniat. /Prague/, 53, 2004, s. 147-150.
8. McGuirt,W.F., Blalock, D., Koufman, J.A., Feehs, R.S., Hillard, A.J., Greven, K., Randall, M.: Comparative voice results after laser resection or irradiation of T1 vocal cord carcinoma. Arch. Otolaryngol. Head Neck Surg., 120, 1994, s. 951-955.
9. Pellant, A., Stránský, P., Šteiner, I.: Karcinom hrtanu u manželů z nepříbuzenského sňatku. Otorinolaryng. a Foniat. /Prague/, 55, 2006, s. 63-65.
10. Strong, M. S.: Laser excision of carcinoma of the larynx. Laryngoscope, 85, 1975, s. 1286-1289.
11. Wedman, J., Heimdal, J.H., Elstad, I., Olofsson, J.: Voice results in patients with T1a glottic cancer treated by radiotherapy or endoscopic measures. Eur. Arch. Otorhinolaryngol., 259, 2002, s. 547-550.
Štítky
Audiology Paediatric ENT ENT (Otorhinolaryngology)Článok vyšiel v časopise
Otorhinolaryngology and Phoniatrics
2007 Číslo 1
Najčítanejšie v tomto čísle
- Quality of Life in Patients with Tracheostomy
- Results of Therapy in Early Stages of Glottic Larynx Cancer Summary
- Chylous Fistulas
- Complex Re-education of Voice in AFC