Late Ototoxicity of Cisplatin in Patients with Medulloblastoma

Česká verzia

Authors: D. Hošnová ¹; T. Kepák ²; M. Brož ²
Authors place of work: Klinika dětské ORL LF MU a FN Brno ¹; Klinika dětské onkologie LF MU a FN Brno ²
Published in the journal: Otorinolaryngol Foniatr, 61, 2012, No. 1, pp. 23-28.
Category: Original Article

Summary

Cisplatin is presently a widely used chemotherapeutic in many types of neoplasms. It causes various side effects, though. The literature indicates sensoric-neural hearing disorder as one of the side effects affecting more than 26% to 90% of patients according to the type of tumor, therapy and patient’s condition. The follow up of hearing is important not only during chemotherapy, when the change of therapeutic plan may prevent significant hearing loss, but also afterwards for late effects of cisplatin use.

Key words:
cisplatin, sensoric-neural hearing disorder, medulloblastoma, late consequences.

Zdroje

1. Gerhard, W. H., Kent, M., Kourosh, P.:Cisplatin-induced ototoxicity: Effect of intratympanic dexamethasone injections. Otol Neurotol., 2008.

2. Kolinsky, D. C., Hayashi, S. S., Karzon, R., Mao, J., Hayashi, R. J.: Late onset hearing loss: A signific and complication of cancer survivors treated with cisplatin containing chemotherapy regimens. Journal of Pediatric Hematology/Oncology, 2010.

3. Kristin, R., Dale, F. K., Edward, A.: Ototoxicity in children receiving platinum chemotherapy: Underestimating a commonly occurring toxicity that may influence academic and social development. Journal of Clinical Oncology, 2005.

4. Kristin, R. K., Dale, F. K.: Early changes in auditory function as a result of platinum chemotherapy: Use of extended high-frequency audiometry and evoked distortion product otoacoustic emissions. Journal of Clinical Oncology, 2007.

5. Sha, S. H., Taylor, R., Forge, A., Schacht, J.: Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals, 2001.

6. Zitterbart, K., Pavelka, Z., Zitterbartová, J.: Meduloblastom: Nejčastější zhoubný nádor mozku u dětí. Onkologie, 2010.