Castleman’s Disease – Mimicking a Malignant Lymphoma
Authors:
Š. Zavázalová 1; P. Jirák 2; M. Syrůček 3; D. Kovář 1; J. Astl 1
Authors place of work:
ORL klinika 3. LF UK a ÚVN Praha, přednosta prof. MUDr. J. Astl, CSc.
1; Oddělení ORL a chirurgie hlavy a krku Nemocnice Na Homolce, Praha, primář oddělení MUDr. P. Jirák
2; Oddělení patologie Nemocnice Na Homolce, primář oddělení MUDr. M. Syrůček
3
Published in the journal:
Otorinolaryngol Foniatr, 63, 2014, No. 4, pp. 246-250.
Category:
Case History
Summary
Castleman’s disease is a rare polyclonal lymphoproliferative disease, which becomes manifest as a benign hyperplasia of lymphatic nodes in various localizations and possibly by systemic symptoms. Histopathology provides division into three groups – hyaline-vascular (most frequent), plasma cellular, and mixed. The clinical manifestation provides a division into unicentric (localized) and multicentric (generalized) form. These variants differ by a clinical course, efficient therapy and prognosis. Histopathological examination is the method of choice in the diagnosis of Castleman’s disease. There has been no standardized therapy so far. It may be certified, though, that a complete surgical removal of the lymph nodes provides a curative method in the unicentric form. In the multicentric form the systemic therapy is necessary as well. In our report the case of a 35 years old man with gradually progressing cervical lymphadenopathy is described.
Keywords:
Castleman’s disease, lymphadenopathy, lymph nodes, histopathologic examination
Zdroje
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2. Majerčáková, D.: Castlemanova choroba. Vnitř. Lék., 58, 2012, 3, s. 216-220.
3. ManmeetKaur Gill, VijaySuri, Vijay K. Dubey, Manisha-Makkar: Cytological diagnosis of Castleman‘s disease of the soft tissue. J. Cytol., 2013, 3, s. 213-215.
4. Mrzena, L.: Diferenciální diagnostika patologických útvarů na krku. Postgraduální medicína, s. 1024-1028.
5. Muzes, G., Sipos, F., Csomor, J., Sréter, L.: Multicentric Castleman’s disease: a challenging diagnosis. Pathol. Oncol. Res., 19, 2013, 3, s. 345-351. doi: 10.1007/s12253-013-9619-z. Epub 2013 Mar 21.
6. Szturz, P., Moulis, M., Adam, Z., Šlaisová, R., Koukalová, R., Řehák, Z., Volfová, P., Hájek, R., Mayer, J.: Castlemanova choroba. Klin. Okol., 24, 2011, 6, s. 424-434.
7. Szturz, P., Plank, L., Kristek, J., Rehak, Z., Koukalova, R., Pipal, R., Tesar, J., Cermakova, Z., Gottwaldova, J., Vanicek, J.,Slaisova, R., Skorpik, M., Adam, Z., Smardova, L., Mayer: Castlemanova choroba v obrazech. Postgraduální medicína 01/2014.
Štítky
Audiology Paediatric ENT ENT (Otorhinolaryngology)Článok vyšiel v časopise
Otorhinolaryngology and Phoniatrics
2014 Číslo 4
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