Nanoparticles, Nanotoxicology, Nanomedicine: Definition of Terms, Perspectives in Otorhinolaryngology
Authors:
L. Čábalová 1,2; Pavel Komínek 1,2
; Karol Zeleník 1,2
; J. Kukutschová 3; L. Čabanová 3
Authors place of work:
Klinika otorinolaryngologie a chirurgie hlavy a krku, Fakultní nemocnice Ostrava, přednosta prof. MUDr. P. Komínek, Ph. D., MBA
1; Katedra kraniofaciálních oborů, Lékařské fakulta, Ostravská univerzita v Ostravě, přednosta prof. MUDr. P. Komínek, Ph. D., MBA
2; Centrum nanotechnologií, Vysoká škola báňská – Technická univerzita Ostrava
3
Published in the journal:
Otorinolaryngol Foniatr, 65, 2016, No. 3, pp. 179-183.
Category:
Review Article
Summary
Nanoparticles are particles smaller than 100 nm in diameter. They are a subject of research interest of two related, closely collaborating scientific disciplines – nanotoxicology and nanotechnology. Nanoparticles are ubiquitous in environment and due to their very small sizes, they possess different properties than the microparticles of the same material (chemical and physical reactivity, interaction with living cells and organisms). Nanotoxicology studies their toxic effect in vitro and in vivo. Nanotechnology develops materials with new properties and functions based on the small size of nanoparticles. Nanomedicine combines new knowledge of nanotechnology and pharmacology to develop new medicaments and therapeutic procedures. The authors summarize current knowledge on nanoparticle properties, their effect on respiratory tract and possible use of nanotechnology in otorhinolaryngology in the article.
Keywords:
nanoparticles, nanotoxicology, nanotechnology, nanomedicine
Zdroje
1. Ahlinder, L., Ekstrand-Hammarström, B., Gelandi, P., Österlund, L.: Large uptake of titania and iron oxide nanoparticles in the nucleus of lung epithelial cells as measured by raman imaging and multivariate classification. Biophysi J., 105, 2013, s. 310-319.
2. Al-Rawi, M., Diabaté, S., Weiss, C.: Uptake and intracellular localization of submicron and nanosized SiO2 particles in HeLa cells. Arch Toxicol, 85, 2011, s. 813-826.
3. British Standars Institution (BSI): Standards Publication: Nanoparticles – Vocabulary. BSI Group, London, 2011.
4. Buckiová, D., Ranjan, S., Newman, T. A., Johnston, A. H., Sood, R., Kinnunen, P. K., Popelář, J., Chumak, T., Syka, J.: Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane. Nanomedicine (Lond), 2012, 9, s. 1339-1354.
5. Dam, D. H., Lee, J. H., Sisco, P. N., Co, D. T., Zhang, M., Wasielewski, M. R., Odom, T. W.: Direct observation of nanoparticle-cancer cell nucleus interactions. ACS Nano, 2012, 6: s. 3318-3326.
6. Damascelli, B., Patelli, G., Tichá, V., Di Tolla, G., Frigerio, L. F., Garbagnati, F., Lanocita, R., Marchiano, A., Spreafico, C., Mattavelli, F., Bruno, A., Zunino, F.: Feasibility and efficacy of percutaneous transcatheter intraarterial chemotherapy with paclitaxel in albumin nanoparticles for advanced squamous-cell carcinoma of the oral cavity, oropharynx and hypopharynx. J. Vasc. Interv. Radiol., 18, 2007, s. 1395-1403.
7. Demir, E., Turna F., Vales, G., Kaya, B., Creus, A., Marcos, R.:In vivo genotoxicity assessment of titanium, zirconium and aluminium nanoparticles, and their microparticulated forms in Drosophila. Chemosphere, 93, 2013, s. 2304-2310.
8. Dürr, S., Tietze, R., Lyer, S., Alexiou, C.: Nanomedizin in der HNO-Heilkunde – ein Ausblick. Laryngo-Rhino-Otol., 91, 2012, s. 6-12.
9. El-Dakdouki, M. H., Xia, J., Zhu, D. C., Kavunja, H., Grieshaber, J., O’Reilly, S., McCormick, J. J., Huang, X.: Assessing the in vivo efficacy of doxorubicin loaded hyaluronan nanoparticles. ACS Appl Mater Interfaces, 2014, 6: s. 697-705.
10. Ellis-Behnke, R., Liang,Y., You, S., Tay, D., Zhang, S., So, K. et al.: Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc. Natl. Acad. Sci., USA, 103, 2006, s. 5054-5059.
11. European Science Foundation. Nanomedicine – An ESF–European Medical Research Councils (EMRC): Forward Look Report. Strasbourgcedex, France ESF, 2004.
12. Farhadi Ghalati, P., Keshavarzian, E., Abouali, O., Faramarzi, A., Tu, J., Shakibafard, A.: Numerical analysis of micro- and nano-particle deposition in a realistic human upper airway. Computers in Biology and Medicine, 42, 2012, s.39-49.
13. Foldbjerg, R., Dang, D. A., Autrup, H.: Cytotoxicity and genotoxicity of silver nanoparticles in the human lungcancer cell line, A549. Arch. Toxicol,, 85, 2011, s.743-750.
14. Garnett, M. C., Kallinteri, P.: Nanomedicines and nanotoxicology: some physiological principles. Occupational Medicíně, 56, 2006, s. 307-311.
15. Gehrke, H., Pelka, J., Hartinger, G., Blank, H., Bleimund, F., Schneider, R., Gerthsen, D., Bräse, S., Crone, M., Türk, M., Marko, D.: Platinum nanoparticles and their cellular uptake and DNA platination at non-cytotoxic concentrations. Arch. Toxicol,, 85, 2011, s.799-812.
16. Genter, M. B., Newman, N. C., Shertzer, H. G., Ali, S. F., Bolon, B.: Distribution and systemic effects of intranasally administered 25 nm silver nanoparticles in adult mice. Toxicko. Pathol., 40, 2012, s. 1004-1013.
17. Hackenberg, S., Scherzed, A., Technau, A., Kessler, M., Froelich, K., Ginzkey, C., Koehler, C., Burghartz, M., Hagen, R., Kleinsasser, N.: Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro. Toxicology in Vitro, 25, 2011, s. 657-663.
18. Jain, N. K.: Pharmaceutical nanotechnology. National Science Digital Library at NISCAIR, India, 2007. Dostupné z http://nsdl.niscair.res.in/bitstream/123456789/748/1/revised+Pharmaceuticall+Nanotech.pdf
19. Kolachala, V. L., Berg, E. E., Shams, S., Mukhatyar, S., Sueblinvong, V., Bellamkonda, R. V., Johns, M. M.: The use of lipid microtubes as a novel slow-release delivery system for laryngeal injection. Laryngoskope, 121, 2011, s. 1237-1243.
20. Kubek, M. J., Domb, A. J., Veronesi, M. C.: Attenuation of kindled seizures by intranasal delivery of neuropeptide-loaded nanoparticles. Neurotherapeutics, 2009, 6: s. 359-371.
21. Kumar, A., Dhawan, A.: Genotoxic and carcinogenic potential of engineered nanoparticles: an update. Arch. Toxicko., 87, 2013, s. 1883-1900.
22. Lai, K. S., Suk, J. S., Pace, A., Wang, Y.-Y., Yang, M., Mert, O., Chen, J., Kim, J., Hanes, J.: Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus. Biomaterials, 32, 2001, s. 6285-6290.
23. Leppänen, M., Korpi, A., Miettinen, M., Leskinen, J., Torvela, T., Rossi, E. M., Vanhala, E., Wolff, H., Alenius, H., Kosma, V. M., Joutsensaari, J., Jokiniemi, J., Pasanen, P.: Nanosized TiO2 caused minor airflow limitation in the murine airways. Arch. Toxicko., 85, 2011, s. 827-839.
24. Li, X., Xu, L., Shao, A., Wu, G., Hanagata, N.: Cytotoxic and genotoxic effects of silver nanoparticles on primary Syrian hamster embryo (SHE) cells. J. Janošci. Nanotechnol., 12, 2013, s. 161-170.
25. Lim, E.-K., Jang, E., Lee, K., Haam, S., Huh, Y.-M.: Delivery of cancer therapeutics using nanotechnology. Pharmaceutics, 2013, 5, s. 294-317.
26. Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A., Liang, X. J.: pH-sensitive nano-systems for drug delivery in cancer therapy. Biotechnol., Adv., 2013, pii: S0734-9750(13)00214-0. doi: 10.1016/j.biotechadv.2013.11.009. [Epub ahead of print].
27. Marano, F., Hussain, S., Rodrigues-Lima, F., Baeza-Squiban, A., Boland, S.: Nanoparticles: molecular targets and cell signalling. Arch. Toxicol., 85, 2011, s. 733-741.
28. Monteiro-Riviere, N. A., Lang Tran, C.: Nanotoxicology: Characterization, Dosing and Health Effects. Informa Healthcare USA, Inc., 2007.
29. Murthy, S. K.: Nanoparticles in modern medicine: state of the art and future challenges. Int. J. Nanomedicine 2007, 2: s. 129-141. Nanoparticles. AIP Conf Proc 2010, 1311: s. 77-88. Nanotechnol., 12, 2013, s. 161-170.
30. Nanotoxicology, HSE (2004). Health effects of particles produced for nanotechnologies. EH75/6 HSE Books, 2004.
31. Ng, C. T., Li, J. J., Gurung, R. L., Hande, M. P., Ong, C. N., Bay, B. H., Yung, L. Y.: Toxicological profile of small airway epithelial cells exposed to gold nanoparticles. Exp. Biol. Med. (Maywood), 238, 2013, s. 1355-1361.
32. Oberdörster, G., Oberdörster, E., Oberdörster, J.: Concepts of nanoparticle dose metric and response metric. Environ Health Perspect, 115, 2007, s. A290.
33. Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Kreyling, W., Cox, C.: Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J. Toxicol. Environ Health A., 20, 2002, s.1531-1543.
34. Patel, S., Chavhan, S., Soni, H., Babbar, A. K., Mathur, R., Mishra, A. K., Sawant, K.: Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route. J. Drug Target, 19, 2011, s. 468-474.
35. Philpott, C. M., Gane, S., McKiernan, D.: Nanomedicine in otorhinolaryngology: what does the future hold? Eur Arch. Otorhinolaryngol., 268, 2011, s. 489-496.
36. Powers, K. W., Brown, S. C., Krishna, V. B., Wasdo, S. C., Moudgil, B. M., Roberts, S. M.: Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation. Toxicological Sciences, 90, 2006, s. 296-303.
37. Prasad, S., Cody, V., Saucier-Sawyer, J. K., Saltzman, W. M., Sasaki, C. T., Edelson, R. L., Birchall, M. A., Hanlon, D. J.: Polymer nanoparticles containing tumor lysates as antigen delivery vehicles for dendritic cell-based antitumor immunotherapy. Nanomedicine, 2011, 7, s. 1-10. Epub 2010 Aug 6.
38. Sakamoto, T., Nakagawa, T., Horie, R. T., Hiraumi, H., Yamamoto, N., Kikkawa, Y. S., Ito, J.: Inner ear drug delivery system from the clinical point of view. Acta Oto-Laryngologica, 2010, s. 101-104.
39. Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR): Modified Opinion (after Public Consultation) on the Appropriateness of Existing Methodologies to Asses the Potential Risks Associated with Engineered and Adventitious Products of Nanotechnologies. Adopted by the SCENIHR during the 10th plenary meeting of 10 March 2006 after public consultation. Dostupné z: http://ec.europa.eu/health/ph_risk/committees/04_scenihr/docs/scenihr_o_003b.pdf
40. Seaton, A.: Nanotoxicology: Hazard and risk. NanoBiotechnology, 2005, Humana Press Inc., s. 316.
41. Shapiro, B., Dormer, K., Rutel, I. B.: A Two-magnet system to push therapeutic nanoparticles. AIP Conf. Prof., 1311, 2010, s. 77-88.
42. Srinivasa, A., Jaganmohan Raoa, P., Selvama, G., Balakrishna Murthya, P., Neelakanta Reddyb, P.:Acute inhalation toxicity of cerium oxide nanoparticles in rats. Toxicology Letters, 205, 2011, s.105-115.
43. Stöver, T., Lenarz, T.: Biomaterialien bei Cochlea-implantaten. Laryngo-Rhino-Otol., 88, 2009, s. S12–S31.
44. Surovtseva, E. V., Johnston, A. H., Zhang, W., Zhang, Y., Kim, A., Murakoshi, M., Wada, H., Newman, T. A., Zou, J., Pyykkö, I.: Prestin binding peptides as ligands for targeted polymersome mediated drug delivery to outer hair cells in the inner ear. Int. J. Pharm., 424, 2012, s. 121-127.
45. Webster, T.: Nanomedicine: what’s in a definition? Int. J. Nanomedicine, 2006, 1, s. 115-116.
46. Weiss, C., Diabaté, S.: Editorial: A special issue on nanotoxicology. Arch. Toxicko., 85, 2011, s. 705-706.
47. Xu, J., Dai, W., Wang, Z., Chen, B., Li, Z., Fan, X.: Intranasal vaccination with chitosan-DNA nanoparticles expressing pneumococcal surface antigen a protects mice against nasopharyngeal colonization by streptococcus pneumoniae. Clin. Vaccine Imunol., 18, 2011, s. 75-81.
48. Xu, J., Li, Z., Xu, P., Xiao, L., Yang, Z.: Nanosized copper oxide induces apoptosis through oxidative stress in podocytes. Arch. Toxicko., 87, 2013, s. 1067-1073.
49. Zamankhan, P., Ahmadi, G., Wang, Z., Hopke, P. K., Cheng, Y. S., Su, W. C., Leonard, D.: Airflow and deposition of nano-particles in a human nasal cavity. Aerosol Science and Technology, 40, 2006, s. 463-476.
50. Zeleník, K., Kukutschová, J., Dvořáčková, J., Bielniková, J., Peikertová, P., Čábalová, L., Komínek, P.: Possible role of nano-sized particles in chronic tonsillitis and tonsillar carcinoma: a pilot study. Eur Arch. Otorhinolaryngol., 270, 2012, s. 705-709.
51. Zhang, W., Zhang, Y., Löbler, M., Schmitz, K. P., Ahmad, A., Pyykkö, I., Zou, J.: Nanoparticles in medicine: Therapeutic applications and developments. Clin. Pharmacol. Ther., 83, 2008, s. 761-769.
52. Zhang, W., Zhang, Y., Löbler, M., Schmitz, K. P., Ahmad, A., Pyykkö, I., Zou, J.: Nuclear entry of hyperbranched polylysine nanoparticles into cochlear ear cells. Int. . Nanomedicine, 2011, 6, s. 535-546.
Štítky
Audiology Paediatric ENT ENT (Otorhinolaryngology)Článok vyšiel v časopise
Otorhinolaryngology and Phoniatrics
2016 Číslo 3
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