Rhino-orbital Mucormycosis

Česká verzia

Authors: G. Neškudlová ¹; D. Kalfeřt ¹; M. Grega ²; M. Kabelková ³; M. Plášková ⁴; J. Plzák ¹
Authors place of work: Klinika otorinolaryngologie a chirurgie hlavy a krku 1. LF a FN v Motole, Praha ¹; Ústav patologie a molekulární medicíny 2. LF UK a FN v Motole, Praha ²; Klinika infekčních, parazitárních a tropických nemocí, Nemocnice Na Bulovce, Praha ³; Oddělení ORL a chirurgie hlavy a krku, Oblastní nemocnice Kladno, a. s., Nemocnice Středočeského kraje, Kladno ⁴
Published in the journal: Otorinolaryngol Foniatr, 68, 2019, No. 3, pp. 171-177.
Category: Case Reports

Summary

Rhinocerebral or rhino-orbito-cerebral mucormycosis (also known as zygomycosis) is a rare invasive fungal infection. Characterised by acute onset, the condition is particularly prevalent in immunocompromised patients and can rapidly result in death. Diabetes mellitus, especially in its decompensated form, is the main predisposing factor. Primary clinical symptoms may mimic orbital complications of rhinosinusitis. Prognosis of the disease depends on the overall condition of the affected patient as well as the stage and rate at which therapy is administered. In this article, we present a case of rhino-orbital mucormycosis in a 54-year-old man with poorly controlled diabetes mellitus followed by a discussion of the clinical symptomatology, diagnosis, and therapy of this seldom-seen but very serious illness.

Keywords:

rhino-orbital – Amphotericin B – diabetes mellitus

Zdroje

1. Almannai, M., Imran, H., Estrada, B. et al.: Successful treatment of rhino-orbital mucormycosis with posaconazole and hyperbaric oxygen therapy. Pediatr Hematol Oncol, 30, 2013, 3, s. 184-186.

2. Čelakovský, P., Vokurka, J., Laco, J. et al.: Invazivní mykotické sinusitidy. Cesk Slov Neurol N, 74, 2011, 2, s. 163-167.

3. Farojov, R., Aydin, O., Yilmaz, C. et al.: Rhino-orbita-maxillary mucormycosis after liver transplantation: A case report. Transplant Proc, 48, 2016, 9, s. 3210-3213.

4. Ferguson, B. J., Mitchell, T. G., Moon, R. et al.: Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis. Rev Infect Dis, 10, 1988, 3, s. 551-559.

5. Haber, J.: Mykotické infekce u onkologického pacienta, přehled léčebných možností. Remedia, 24, 2014, 1, s. 36-41.

6. Hargrove, R. N., Wesley, R. E., Klippenstein, K. A. et al.: Indications for orbital exenteration in mucormycosis. Ophthalmic Plast Reconstr Surg, 22, 2006, 4, s. 286-291.

7. Herrera, D. A., Dublin, A. B., Ormsby, E. L. et al.: Imaging findings of rhinocerebral mucormycosis. Skull Base, 19, 2009, 2, s. 117-125.

8. Howells, R. C., Ramadan, H. H.: Usefulness of computed tomography and magnetic resonance in fulminant invasive fungal rhinosinusitis. Am J Rhinol, 15, 2001, 4, s. 255-261.

9. Chrenková, V., Hubáček, P., Weinbergerová, B. et al.: Invazivní mukormykóza u dětských hematoonkologických pacientů: zkušenosti 2005-2010. Klin Mikrobiol Infekc Lek, 18, 2012, 4, s. 102-108.

10. Imbernon, A., Agud, J. L., Cuetara, M. S. et al.: Successful therapy of progressive rhino-orbital mucormycosis caused by Rhizopus arrhizus with combined and sequential antifungal therapy, surgery and hyperbaric therapy. Med Mycol Case Rep, 6, 2014, s. 51-54.

11. Janušková, V., Komínek, P., Kostřicová, E. et al.: Mukormykóza nosní a ústní dutiny. Otorinolaryng a Foniat /Prague/, 50, 2001, 4, s. 250-252.

12. Karadeniz Ugurlu, S., Selim, S., Kopar, A. et al.: Rhino-orbital mucormycosis: clinical findings and treatment outcomes of four cases. Turk J Ophthalmol, 45, 2015, 4, s. 169-174.

13. Kontoyiannis, D. P., Lewis, R. E., Lortholary, O. et al.: Future directions in mucormycosis research. Clin Infect Dis, 54, 2012, Suppl 1, s. S79-85.

14. Lysková, P., Žačková, P., Petečuková, V. et al.: Plicní mukormykóza vyvolaná Rhizopus microsporus. Klin Mikrobiol Infekc Lek, 19, 2013, 4, s. 132-137.

15. Mantadakis, E., Samonis, G.: Clinical presentation of zygomycosis. Clin Microbiol Infect, 15, 2009, Suppl 5, s. 15-20.

16. Marák, J., Hejsek, L., Jakoubková, S. et al.: Rinocerebrální forma mukormykózy u mladé diabetičky. Kazuistiky v diabetol, 15, 2017, 2, s. 21-24.

17. Paltauf, A.: Mycosis mucorina - Ein Beitrag zur Kenntniss der menschlichen Fadenpilzerkrankungen. Virchows‘ Arch Pathol Anat, 102, 1885, 3, s. 543-564.

18. Peterson, K. L., Wang, M., Canalis, R. F. et al.: Rhinocerebral mucormycosis: evolution of the disease and treatment options. Laryngoscope, 107, 1997, 7, s. 855-862.

19. Petrikkos, G., Skiada, A., Lortholary, O. et al.: Epidemiology and clinical manifestations of mucormycosis. Clin Infect Dis, 54 Suppl 1, 2012, s. S23-34.

20. Plowes Hernandez, O., Prado Calleros, H. M., Soberon Marmissolle Daguerre, G. S. et al.: Rhino-orbito-cerebral mucormycosis. Management strategies to avoid or limit intracraneal affection and improve survival. Acta Otorrinolaringol Esp, 66, 2015, 6, s. 348-352.

21. Rammaert, B., Lanternier, F., Poiree, S. et al.: Diabetes and mucormycosis: a complex interplay. Diabetes Metab, 38, 2012, 3, s. 193-204.

22. Rapidis, A. D.: Orbitomaxillary mucormycosis (zygomycosis) and the surgical approach to treatment: perspectives from a maxillofacial surgeon. Clin Microbiol Infect, 15 Suppl 5, 2009, s. 98-102.

23. Saedi, B., Sadeghi, M., Seilani, P.: Endoscopic management of rhinocerebral mucormycosis with topical and intravenous amphotericin B. J Laryngol Otol, 125, 2011, 8, s. 807-810.

24. Seiff, S. R., Choo, P. H., Carter, S. R.: Role of local amphotericin B therapy for sino-orbital fungal infections. Ophthalmic Plast Reconstr Surg, 15, 1999, 1, s. 28-31.

25. Scheckenbach, K., Cornely, O., Hoffmann, T. K. et al.: Emerging therapeutic options in fulminant invasive rhinocerebral mucormycosis. Auris Nasus Larynx, 37, 2010, 3, s. 322-328.

26. Son, J. H., Lim, H. B., Lee, S. H. et al.: Early differential diagnosis of rhino-orbito-cerebral mucormycosis and bacterial orbital cellulitis: based on computed tomography findings. PLoS One, 11, 2016, 8, s. e0160897.

27. Spellberg, B., Edwards, J., Jr., Ibrahim, A.: Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev, 18, 2005, 3, s. 556-569.

28. Talmi, Y. P., Goldschmied-Reouven, A., Bakon, M. et al.: Rhino-orbital and rhino-orbito-cerebral mucormycosis. Otolaryngol Head Neck Surg, 127, 2002, 1, s. 22-31.

29. Trief, D., Gray, S. T., Jakobiec, F. A. et al.: Invasive fungal disease of the sinus and orbit: a comparison between mucormycosis and Aspergillus. Br J Ophthalmol, 100, 2016, 2, s. 184-188.

30. Vironneau, P., Kania, R., Morizot, G. et al.: Local control of rhino-orbito-cerebral mucormycosis dramatically impacts survival. Clin Microbiol Infect, 20, 2014, 5, s. 336-339.