Microenvironment of squamous cell carcinoma of the head and neck as an analogy of a healing wound

Česká verzia

Authors: V. Bandúrová ^1,2 ; K. Smetana ² ; J. Plzák ^1,2 ; B. Dvořánková ²
Authors place of work: Klinika otorinolaryngologie a chirurgie hlavy a krku 1. LF UK a FN v Motole, Praha ¹; Anatomický ústav 1. LF UK, Praha ²
Published in the journal: Otorinolaryngol Foniatr, 71, 2022, No. 1, pp. 18-23.
Category: Review Article
doi: https://doi.org/10.48095/ccorl202218

Summary

Numerous interactions occur among fibroblasts, keratinocytes and immune cells during wound healing. The release of cytokines supports formation of granular tissue which then fills the wound. A chronic wound appears when this complex process is disrupted. We can see this problem in patients with diabetes. Granular tissue is very similar to the stroma of solid tumors. This work is focused on parallels between a healing wound and tumor. It aims to clearly describe the regulation of both processes. New knowledge in this field can contribute to revealing new therapeutic possibilities in chronic wounds and solid tumors.

Keywords:

squamous cell carcinoma – Head and neck tumors – healing – tumor microenvironment

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