The microbiome and chronic rhinosinusitis

Česká verzia

Authors: K. Mamiňák ^1,2 ; D. Funda ³ ; Š. Zavázalová ^1,2 ; T. Filipovský ^1,2 ; D. Kovář ^1,2 ; K. Janoušková ^1,2 ; R. Holý ^1,2 ; J. Astl ^1,2
Authors place of work: Klinika otorinolaryngologie a maxilofaciální chirurgie 3. LF UK a ÚVN Praha ¹; 3. lékařská fakulta, Univerzita Karlova, Praha ²; Laboratoř buněčné a molekulární imunologie, Mikrobiologický ústav Akademie věd ČR, v. v. i. ³
Published in the journal: Otorinolaryngol Foniatr, 73, 2024, No. 3, pp. 182-190.
Category: Review Article
doi: https://doi.org/10.48095/ccorl2024182

Summary

Chronic rhinosinusitis (CRS) is a complex heterogeneous inflammatory disease of the nasal cavity and paranasal sinuses, which very often leads to a decrease in the quality of life with subsequent socioeconomic burden on health services and medical care. CRS is clinically divided into chronic rhinosinusitis with polyps (CRSwNP) and chronic rhinosinusitis without polyps (CRSsNP). Currently, research focuses on the composition of microflora in individual parts of the human body, which has already helped clarify the role of the microbiome in inflammatory respiratory diseases such as bronchial asthma and chronic obstructive pulmonary disease (COPD). Furthemore, research also focuses on the role of the nasal microbiome in possible initiation and potentiation of CRS. A healthy nasal microbiological environment is composed of bacteria, fungi, and viruses. A closer understanding of interactions between microbes and individual components of the immune system may help clarify the pathophysiological mechanisms involved during CRS. In this review article, we will focus on the current knowledge of composition changes and the possible role of the complex microbiome of the upper respiratory tract in CRS compared to a healthy nasal environment.

Keywords:

mucosal immunity – chronic rhinosinusitis – Microbiome – probiotics – chronic inflammation

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ORCID autorů

K. Mamiňák 0000-0002-3935-5891,

D. Funda 0000-0001-8327-6931,

Š. Zavázalová 0000-0002-2710-119X,

T. Filipovský 0000-0002-9462-0635,

K. Janoušková 0000-0003-3939-7538,

R. Holý 0000-0003-1112-6197,

J. Astl 0000-0002-8022-0200.

Přijato k recenzi: 3. 8. 2023

Přijato k tisku: 13. 11. 2023

MUDr. Kristýna Mamiňák

Klinika otorhinolaryngologie a maxilofaciální chirurgie