Hormonally-active tumours in differential diagnostics of precocious puberty in girls between 1973 and 2008

Česká verzia

Authors: J. Hořejší
Authors place of work: 2. LF UK a FN Motol, Praha ; Gynekologicko-porodnická klinika
Published in the journal: Prakt Gyn 2010; 14(2): 68-70
Category: Original Article

Summary

Hormonally-active tumours in differential diagnostics of precocious puberty in girls between 1973 and 2008. This abstract had

been published in Gynaecology Practice 2008 (S4), 269.

The presentation of precocious puberty in girls is most likely incomplete (premature thelarche or thelarche variant). The true precocious puberty is classified according to the gonadotropic hormones levels as follows:

- gonadotropin-dependent precocious puberty (also known as true or central, usually idiopathic precocious puberty) with increased gonadotropic hormones levels and with post-puberty response to LHRH-stimulating test.

- gonadotropin-independent precocious puberty, i.e. with gonadotropin levels within the population normal range for girls of the same age

- precocious puberty due to hormonally-active (feminizing) tumour of the ovary. With respect to this classification principle, it is characterized by significant reduction (up to undetectable levels) of FSH and LH. Hormonally-active tumours are the rarest but, from the perspective of the girl‘s life expectancy, the most serious of the causes of precocious puberty. Differential diagnosis of hormonally-active tumour is not always easy, as is documented in some of the cases from the author’s own 35 years of experience.

Key words:
precocious puberty - gonadotropin-independent precocious puberty - hormonally-active ovarian tumour

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