Resveratrol in oncogynecology

Česká verzia

Authors: Alena Šestinová
Authors place of work: Gynekologicko-porodnická klinika, 1. LF UK a VFN, Praha, přednosta prof. MUDr. Alois Martan, DrSc.
Published in the journal: Prakt Gyn 2013; 17(3): 217-219
Category: Oncogynecology: Review Article

Summary

Resveratrol is a fytoalexin produced naturally by the plants as a response to the stress, injury or fungal infection. Resveratrol was isolated from red wine and was connect with cardioprotective effect of this. Resveratrol exhibits a wide range of biological effects, including protection of the cardiovascular system and skin cells and is also proposed as a cancer – preventive agent.

Key words:
cancerogenesis – cardiovascular disease – resveratrol

Zdroje

1. Šmidrkal J, Filip V, Melzoch K, Hanzlíková I, Buckiová D, Křísa B. Resveratrol. Chem Listy 2001; 95(10): 602–609.

2. Paul B. Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India. J Ethnopharm 1999; 68 (1–3): 71–76.

3. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000; 130(8S Suppl): 2073S-2085S.

4. Sexton E, Van Themsche C, LeBlanc K et al. Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Mol Cancer 2006; 5: 45.

5. Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta, Endocrinology 2000; 141(10): 3657–3667.

6. Šamánek M, Dobiášová M, Urbanová Z et al. Pití bílého vína k večeři oddaluje aterosklerózu a působí antikoagulačně. Čas Lék Čes 2002; 141: 251–254.

7. Šamánek M, Urbanová Z. Když víno léčí. Galén: Praha 2013. ISBN: 978–80–7262–972–95.

8. Grønbaek M, Tjønneland A, Johansen D et al. Type of alcohol and drinking pattern in 56,970 Danish men and women. Eur J Clin Nutr 2000; 54(2): 174–176.

9. Kannel WB, Ellison RC. Alcohol and coronary heart disease: the evidence for a protective effect. Clin Chim Acta 1996; 246(1–2): 59–76.

10. Rimm EB, Williams P, Fosher K et al. Moderate alcohol intake and lower risk of coronary heart disease: Meta-analysis of effects on lipids and haemostatic factors. BMJ 1999; 319 (7224): 1523–1528.

11. Buonocore D, Lazzeretti A, Tocabens P et al. Resveratrol – procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebocontrolled, double-blind study. Clin Cosmet Investig Dermatol 2012; 5: 159–165.

12. Vidavalur R, Otani H, Singal PK, Maulik N. Significance of wine and resveratrol in cardiovascular disease: French paradox revisited. Exp Clin Cardiol 2006; 11(3): 217–225.