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The role of estrogens in regulations of biological processes involved into wound healing – a review


Authors: Vlasta Peržeľová 1,2;  Martin Slezák 1;  Silvia Toporcerová 3;  Peter Gál 1,2,4
Authors place of work: Východoslovenský ústav srdcových a cievnych chorôb, a. s., Košice 1;  Univerzita veterinárskeho lekárstva a farmácie, Košice 2;  Univerzita Pavla Jozefa Šafárika a Univerzitná nemocnica Louisa Pasteura v Košiciach, II. gynekologicko-pôrodnícka klinika 3;  Univerzita Karlova v Praze, 1. lékařská fakulta, Ústav pro histologii a embryologii 4
Published in the journal: Čas. Lék. čes. 2011; 150: 599-604
Category: Přehledové články

Summary

Since the average age of female population in developed countries has increased, women live up to one-third of their life in the post-menopausal period during which altered wound healing frequently occurs. It has been shown that estrogens and estrogen receptors play a key role in the regulation of processes involved in tissue repair and regeneration. Hence, for better orientation in this area of biomedical research and clinical practice the role of estrogens and their receptors in wound healing was described in this review.

Key words:
post-menopausal period, aging, steroid hormones, tissue repair and regeneration, inflammation.


Zdroje

1. Barrett-Connor E. Epidemiology and the menopause: a global overview. Int J Fertil Menopausal Stud 1993; 38(Suppl 1): 6–14.

2. Hall G, Philips TJ. Estrogen and skin: the effects of estrogen, menopause, and hormone replacement therapy on the skin. J Am Acad Dermatol 2005; 53: 555–568.

3. Kovacs EJ. Aging, traumatic injury, and estrogen treatment. Exp Gerontol 2005; 40: 549–555.

4. Margolis DJ, et al. Hormone replacement therapy and prevention of pressure ulcers and venous leg ulcers. Lancet 2002; 359: 675–677.

5. Warren MP. A comparative review of the risks and benefits of hormone replacement therapy regimens. Am J Obstet Gynecol 2004; 190: 1141–1167.

6. Emmerson E, et al. Unique and synergistic roles for 17ß--estradiol and macrophage migration inhibitory factor during cutaneous wound closure are cell type specific. Endocrinology 2009; 150: 2749–2757.

7. Toporcer T, Radoňák J. Podtlakové uzatváranie rán – nové poznatky a možnosti aplikácie. Čas Lek čes 2006; 145: 702–707.

8. Grohé C, et al. Cardiac myocytes and fibroblasts contain functional estrogen receptors. FEBS Lett 1997; 416: 107–112.

9. Lindner V, et al. Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury. Circ Res 1998; 83: 224–229.

10. Thornton MJ. The biological actions of estrogens on skin. Exp Dermatol 2002; 11: 487–502.

11. Greene GL, et al. Sequence and expression of human estrogen receptor complementary DNA. Science 1986; 231: 1150–1154.

12. Mosselman S, et al. ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett 1996; 392: 49–53.

13. Li X, et al. Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways. Mol Cell Biol 2004; 24: 7681–7694.

14. O’Dowd BF, et al. Discovery of three novel G-protein-coupled receptor genes. Genomics 1998; 47: 310–313.

15. Bakas P, et al. Estrogen receptor alpha and beta in uterine basis for altered estrogen responsiveness. Fertil Steril 2008; 90: 1878–1885.

16. Stevenson S, et al. Differing responses of human follicular and nonfollicular scalp cells in an in vitro wound healing assay: Effects of estrogen on vascular endothelial growth factor secretion Wound Repair Regen 2008; 16: 243–253.

17. Kuiper GG, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997; 138: 863–870.

18. Smith CL, et al. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev 2004; 25: 45–71.

19. Santen RJ. Recent progress in development of aromatase inhibitors. J Steroid Biochem Mol Biol 1990; 37: 1029–1035.

20. Vokrouhlická J, et al. Selective estrogen receptor modulators as a new concept in preventing health risks of menopause. Čas Lek čes 1998; 137: 679–685.

21. Herrick S, et al. Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation. Lab Invest 1997; 77: 281–288.

22. Hardman MJ, et al. Macrophage migration inhibitory factor: a central regulator of wound healing. Am J Pathol 2005; 167: 1561–1574.

23. Ashcroft GS, et al. Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest 2003; 111: 1309–1318.

24. Hardman MJ, et al. Selective Estrogen Receptor Modulators Accelerate Cutaneous Wound Healing in Ovariectomized Female Mice. Endocrinology 2008; 149: 551–557.

25. Emmerson E, et al. The phytoestrogen genistein promotes wound healing by multiple independent mechanisms. Mol Cell Endocrinol 2010; 321: 184–193.

26. Mills SJ, et al. The Sex Steroid Precursor DHEA Accelerates Cutaneous Wound Healing Via the Estrogen Receptors. J Invest Dermatol 2005; 125: 1053–1062.

27. Ashcroft GS, et al. Topical Estrogen Accelerates Cutaneous Wound Healing in Aged Humans Associated with an Altered Inflammatory Response. Am J Pathol 1999; 155: 1137–1146.

28. Ashcroft GS, et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med 1997; 3: 1209–1215.

29. Campbell L, et al. Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities. J Exp Med 2010; 207: 1825–1833.

30. Merlo S, et al. Differential involvement of estrogen receptor alpha and estrogen receptor beta in the healing promoting effect of estrogen in human keratinocytes. J Endocrinol 2009; 200: 189–197.

31. Gilliver SC, et al. 17ß-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α. Am J Pathol 2010; 176: 2707–2721.

32. Marini H, et al. Genistein aglycone improves skin repair in an incisional model of wound healing: a comparison with raloxifene and oestradiol in ovariectomized rats. Br J Pharmacol 2010; 160: 1185–1194.

33. Fujimoto J, et al. Ovarian steroids regulate the expression of basic fibroblast growth factor and its mRNA in fibroblasts derived from uterine endometrium. Ann Clin Biochem 1997; 34(Pt 1): 91–96.

34. Stevenson S, et al. 17beta-estradiol regulates the secretion of TGF-beta by cultured human dermal fibroblasts. J Biomater Sci Polym Ed 2008; 19: 1097–1109.

35. Stevenson S, et al. Effects of oestrogen agonists on human dermal fibroblasts in an in vitro wounding assay. Exp Dermatol 2009; 18: 988–990.

36. Pirilä E, et al. Wound Healing in Ovariectomized Rats: Effects of Chemically Modified Tetracycline (CMT-8) and Estrogen on Matrix Metalloproteinases -8, -13 and Type I Collagen Expression. Curr Med Chem 2001; 8: 281–294.

37. Novotný M, et al. ER-α agonist induces conversion of fibroblasts into myofibroblasts, while ER-ß agonist increases ECM production and wound tensile strength of healing skin wounds in ovarectomized rats. Exp Dermatol 2011; 20: 703–708.

38. Ashcroft GS, et al. Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA. J Pathol 1997; 183: 169–176.

39. Pirilä E, et al. Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats: Effects on matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and laminin-5 c2-chain. Wound Repair Regen 2002; 10: 38–51.

40. Sato T, et al. Hormonal regulation of collagenolysis in uterine cervical fibroblasts. Modulation of synthesis of procollagenase, prostromelysin and tissue inhibitor of metalloproteinases (TIMP) by progesterone and oestradiol-17 beta. Biochem J 1991; 275(Pt 3): 645–650.

41. Kassira N, et al. Estrogen deficiency and tobacco smoke exposure promote matrix metalloproteinase-13 activation in skin of aging B6 mice. Ann Plast Surg 2009; 63: 318–322.

42. Battegay EJ, et al. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors. J Cell Biol 1994; 125: 917–928.

43. Ruffy MB, et al. Effects of Tamoxifen on Normal Human Dermal Fibroblasts. Arch Facial Plast Surg 2006; 8: 329–332.

44. Ashcroft GS, Ashworth JJ. Potential role of estrogens in wound healing. Am J Clin Dermatol. 2003; 4: 737–743.

45. Morales DE, et al. Estrogen promotes angiogenic activity in human umbilical vein endothelial cells in vitro and in a murine model. Circulation. 1995; 91: 755–763.

46. Shah M, et al. Control of scarring in adult wounds by neutralising antibody to transforming growth factor beta. Lancet. 1992; 339: 213–214.

47. Mikulec AA, et al. Effect of tamoxifen on transforming growth factor beta1 production by keloid and fetal fibroblasts. Arch Facial Plast Surg 2001; 3: 111–114.

48. Mousavi SR, et al. Evaluating tamoxifen effect in the prevention of hypertrophic scars following surgical incisions. Dermatol Surg 2010; 36: 665–669.

49. Gál P, et al. Early changes in the tensile strength and morphology of primary sutured skin wounds in rats. Folia Biol (Praha) 2006; 52: 109–115.

50. Kuiper GG, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998; 139: 4252–4263.

51. Gál P, et al. Postsurgical Administration of Estradiol Benzoate Decreases Tensile Strength of Healing Skin Wounds in Ovariectomized Rats. J Surg Res 2008; 147: 117–122.

52. Gál P, et al. Decrease in wound tensile strength following post-surgical estrogen replacement therapy in ovariectomized rats during the early phase of healing is mediated via ER-alpha rather than ER-beta: a preliminary report. J Surg Res 2010; 159: 25–28.

53. Pallin B, et al. Granulation tissue formation in oophorectomized rats treated with female sex hormones. II. Studies on the amount of collagen and on tensile strength. Acta Chir Scand 1975; 141: 710–714.

54. Mosconi P, et al. Informing women about hormone replacement therapy: the consensus conference statement. BMC Womens Health. 2009; 9: 14.

55. Collaborative Group on Hormonal Factors in Breast Cancer: Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer. Lancet 1997; 350: 1047–1059.

56. Saxena T, et al. Menopausal hormone therapy and subsequent risk of specific invasive breast cancer subtypes in the California Teachers Study. Cancer Epidemiol Biomarkers Prev. 2010; 19: 2366–2378.

Štítky
Adiktológia Alergológia a imunológia Angiológia Audiológia a foniatria Biochémia Dermatológia Detská gastroenterológia Detská chirurgia Detská kardiológia Detská neurológia Detská otorinolaryngológia Detská psychiatria Detská reumatológia Diabetológia Farmácia Chirurgia cievna Algeziológia Dentální hygienistka

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