Nejvýznamnější markery receptivity endometria

Cíl studie:
Vyhledat markery nedostatečné kvality endometria.

Typ studie:
Literární přehled.

Pracoviště:
Gynekologicko-porodnická klinika 1. LF UK a VFN Praha.

Výsledky:
Předkládáme přehled faktorů ovlivňujících receptivitu endometria. Data ukazují na význam exprese genů ze skupiny homeobox, zejména HOX10 a HOX 11, které zajišťují proces implantace svojí interakcí s estrogenními a progesteronovými receptory cestou stimulačních proteinů v luteální fázi. Optimální stav sliznice děložní v proliferační fázi je dán přiměřenou sekrecí osteoponinu, kadherinu, selektinu, apolipoproteinu D, mucinu a přiměřenou aktivitou makrofágů.

Závěr:
Receptivita endometria je ovlivněna expresí genů v endometriu současně s aktivitou makrofágů v nitroděložním prostředí.

Klíčová slova:
selhání implantace, receptivita endometria, exprese genů, osteoponin, integrin β3, apolipoprotein D, kadheriny, selektiny, HOX geny

Autoři: N. Kushniruk; Tomáš Fait
Působiště autorů: Head of Department prof. MUDr. A. Martan, DrSc. ; Department of Obstetrics and Gyneacology, 1st Faculty of Medicine, Charles University, General Faculty Hospital, Prague
Vyšlo v časopise: Ceska Gynekol 2014; 79(4): 269-275

Souhrn

Cíl studie:
Vyhledat markery nedostatečné kvality endometria.

Typ studie:
Literární přehled.

Pracoviště:
Gynekologicko-porodnická klinika 1. LF UK a VFN Praha.

Závěr:
Receptivita endometria je ovlivněna expresí genů v endometriu současně s aktivitou makrofágů v nitroděložním prostředí.

Klíčová slova:
selhání implantace, receptivita endometria, exprese genů, osteoponin, integrin β3, apolipoprotein D, kadheriny, selektiny, HOX geny

Zdroje

1. Achajanova, L. Leukemia inhibitory factor and human embryo implantation. Annals on the New York Academy of Sciences, 2004, 1034, p. 176–183.

2. Cakmak, H., Taylor, HS. Implantation failure: molecular mechanisms and clinical treatment. Hum Reprod Update, 2011, 17(2), p. 242–253.

3. Campbell, S., Larsen, J., Seif, MW., et al. Mosaic characteristics of human endometrial epithelium in vitro: analysis of secretory markers and cell surface ultrastructure. Mol Hum Reprod, 2000, 6(1), p. 41–49.

4. Chang, PL., Sauer, MV. The oocyte donation model: lesson on endometrial receptivity.The endometrium. London: Taylor and Francis, 2002, p. 495–509.

5. Cheong, Y., Boomsma, C., Heijnen, C., et al. Uterine secretomes: a window of a maternal-embryo interface. Fertil Steril, 2013, 99(4), p. 1093–1099.

6. Critchley, HO., Robertson, KA., Forster, T., et al. Gene expression profiling of mid to late secretory phase endometrial biopsies from women with menstrual complaint. Am J Obstet Gynecol, 2006, 195, p. 406–422.

7. Davis, BJ., Lennard, DE., Lee, CA., et al. Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta. Endocrinology, 1999, 140, p. 2685–2695.

8. Dunlap, KA., Filant, J., Hayashi, K., et al. Postnatal detection of Wnt7a inhibits uterine glands microgenesis and compomices adult fertility in mice. Biol Reprod, 2011, 85, p. 386–396.

9. Fazleabas, AT., Brudney, A., Chai, D., et al. Steroid receptor and aromatase expression in baboon endometriotic lesions. Fertil Steril, 2003, 80(2S), p. 820–827.

10. Fleming, TP., Kwong, W., Porter, R., et al. The embryo and its future. Biol Reprod, 2004, 71, p. 1046–1054.

11. Fleming, TP., Velazquez, MA., Eckert, JJ., et al. Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring. Anim Reprod Sci, 2012, 130, p. 193–197.

12. Foucher, I., Volovitch, M., Frain, M., et al. Hoxa5 overexpression correlates with IGFBP1up-regulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors. Development, 2002, 129, p. 4065–4074.

13. Garrido-Gómez, T., Ruiz-Alonso, M., Blesa, D., et al. Profiling the gene signature of endometrial receptivity: clinical results. Fertil Steril, 2013, 99(4), p. 1078–1185.

14. Grindler, NM., Moley, KH. Maternal obesity, infertility and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems. Molec Hum Reprod, 2013, 19(8), p. 486–494.

15. Hannan, NJ., Stephens, AN., Rainczuk, A., et al. 2D-DiGE analysis of the human endometrial secretome reveals differences between receptive and nonreceptive states in fertile and infertile women. J Proteome Res, 2010, p. 9, p.,6256–6264.

16. Heng, S., Hannan, HJ., Rombouts, LI., et al. PC6 level in uterine lavage are closely associated with uterine receptivity and dsignificantly lower in the subgroup of women with unexplained infertility. Hum Reprod, 2011, 26, p. 840–846.

17. Horcajadas, JA., Riesewijk, A., Polman, J., et al. Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Mol Hum Reprod, 2005, 11, p. 195–205.

18. Horne, AW., White, JO., Lalani, N., et al. Analysis of epitopes on endometrial epithelium by scanning immunoelectron microscopy. Biochem Biophys Res Commun, 2002, 292, p. 102–108.

19. Jasper, MJ., Care, AS., Sullivan, B., et al. Macrophage – derived LIF and IL IB regulate alpha (1,2) flucotransferase 2 (Fut 2) expression in mouse uterine epithelial cells during early pregnancy. Biol Reprod, 2010, 84, p. 179–188.

20. Jeong, JW., Kwak, I., Lee, KY., et al. Foxa 2 is essential for mouse endomential gland development and infertility. Biol Reprod, 2010, 83, p. 396–403.

21. Kim, JJ., Taylor, HS., Lu, Z., et al. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol Hum Reprod, 2007, 3, p. 323–332.

22. Kumar, S., Zhu, LJ., Polihronis, M., et al. Progesterone induces calcitonin gene expression in human endometrium within the putative window of implantation. J Clin Endocrinol Metab, 1998, 83, p. 4443–4450.

23. Laird, SM., Tuckerman, EM., Li, TC. Cytokine expression in the endometrium of women with implantation failure and recurrent miscarriage. Reprod Biomed Online, 2006, 13, p. 13–23.

24. Lessey, BA., Damjanovich, L., Coutifaris, C., et al. Integrin adhesion molecules in the human endometrium. J Clin Invest, 1992, p. 188–195.

25. Lessley, BA. Assessment of endometrial receptivity. Fertil Steril, 2011, 96, p. 522–529.

26. Lewis, EB. A gene complex controlling segmentation in Drosophila. Nature, 1978, 276, p. 565–570.

27. Macklan, NS., Geraedts, JP., Fauser, BC., et al. Conception to ongoing pregnancy: the ‘back box’ of early pregnancy loss. Hum Reprod Update, 2002, 8, p. 333–343.

28. Martinez, FO., Helming, L., Gordon, S. Alternative activation of macrophages: an immunologic functional perspective. Ann Rev Immunol, 2009, 27, p. 451–483.

29. Merviel, P., Challier, JC., Carbillon, L., et al. The role of integrins in human embryo implantation. Fetal Diagn Ther, 2001, 16(6), p. 364–371

30. Meseguer, M., Pellicer, A., Simon, C. MUC1 and endometrial receptivity. Mol Hum Reprod, 1999, 4(12), p. 1089–1098.

31. Miller, DL., Jones, CJ., Aplin, JD., et al. Altered glycosylation in peri-implantation phase endometrium in women with stages III and IV endometriosis. Hum Reprod, 2010, 25, p. 406–411.

32. Nakamura, H., Jasper, M., Hull, M., et al. Macrophages regulate expression of α 1,2 – fucosyltransferase genes in human endometrium epithelium cells. Molec Hum Reprod, 2012, 18(4), p. 204–215.

33. Parmar, T., Gadkar-Sable, S., Savardekar, L., et al. Protein profiling of human endometrial tissues in the midsecretory and proliferative phases of the menstrual cycle. Fertil Steril, 2009, 92, p. 1091–1103.

34. Quinn, CE., Casper, RF. Pinopodes: a questionable role in endometrial receptivity. Hum Reprod Update, 2009, 15, p. 229–236.

35. Revel, A., Achahce, H., Stevens, J., et al. Micro RNAs are assosiated with human embryo implantation defects. Hum Reprod, 2011, 26, p. 2830–2840.

36. Salamonsen, LA., Edgell, T., Rombautes, LJF., et al. Proteomics of human endometrium and uterine fluid: a pathway to biomarker discovery. Fertil Steril, 2013, 99(4), p. 1086–1092.

37. Stewart, CL., Kaspar, P., Brunet, LJ., et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature, 1992, 359, p. 76–79.

38. Strakey, AM., Smith, SK. The endometrium as a cause of implantation failure. Best Pract Res Clin Obstetr Gyneacol, 2003, 17, p. 289–307.

39. Strowitski, T., Germeyer, A., Popovici, R., von Wolff, M. The human endometrium as a fertility – determining factor. Hum Reprod Update, 2006, 12, p. 617–630.

40. Tapia, A., Vilos, C., Marin, JC., et al. Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potentional regulators of genes associated to acquisition of endometrial receptivity. Reprod Biol Endocrin, 2011, 27, p. 9–14.

41. Taylor, H., Igarashi, P., Olive, D. Sex steroids mediate Hoxa11 expression in the human peri-implantation endometrium. J Clin Endocrinol Metab, 1999, 84, p. 1129–1135.

42. Taylor, HS., Baget, C., Kardana, A., et al. HOX gene expression is altered in the endometrium of women with endometriosis. Hum Reprod, 1999a, 14, p. 1328–1331.

43. Van der Gaast, MH., Macklon, NS., Beier-Hellwig, K., et al. The feasibility of a less invasive method to assess endometrial maturation—comparison of simultaneously obtained uterine secretion and tissue biopsy. BJOG, 2009, 116, p. 304–312.

44. Vargas, MF., Tapia-Pizarro, M., Henríquez, S., et al. Effect of single post-ovulatiory administration of levonorgestrel on gene expression profile during the receptive period of the human endometrium. J Mol Endocr, 2012, 48(1), p. 25–36.

45. Wang, YA., Chamber, GM., Sullivan, EA. Assisted reproductive technology in Australia and New Zealand 2008. Assisted reproduction technology series № 16. Canberra: Australian Institute of Health and Welfare 2012.

46. Wu, D., Song, D., Li, X., Yu, M. Molecular characterization and identification of the E2/P4 response element in the porcine HOXA 10 gene. Mol Cell Biochem, 2013, 374, p. 213–222.

47. Xiao, Y., Li, T., Xia, E., et al. Expression of integrin b3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window. Europ J Obst Gynec Reprod Biol, 2013, 170, p. 419–422.