Prebioptic methods in the cervical cancer screening

Česká verzia

Authors: V. Dvořák ¹; R. Pilka ²; M. Lubušký ²; K. Langová ³
Authors place of work: Centrum ambulantní gynekologie a primární péče, Brno ¹; Gynekologicko-porodnická klinika FN a LF UP, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D. ²; Ústav lékařské biofyziky LF UP, Olomouc ³
Published in the journal: Ceska Gynekol 2014; 79(4): 260-268

Summary

Objective:
To evaluate the agreement between Pap smears, colposcopic findings and definitive excisional specimen in patients with abnormal Pap smears.

Design:
Retrospective study.

Setting:
Center of outpatient gynecology and primary care, Brno; Department of Obstetrics and Gynecology, University Hospital, Olomouc; Department of Medical Biophysics, Palacky University, Olomouc.

Subjects and methods of the study:
This retrospective study assessed the correlation between colposcopy and histopathology of woman who had abnormal Pap smears. Colposcopic chart review included participants from 2008 to 2012 who attended colposcopic clinic, center of outpatient gynecology care, Brno.

Results:
One thousand nine hundred and twenty five patients screened by cytology, submitted to colposcopy and subjected to cone biopsy were selected. Cytopathological results were compared with colposcopic findings and results obtained on the basis of histological analyses of cone biopsy specimen. Agreement of cytology and histopathological diagnosis was in 1199 patients (62.3%). Agreement of colposcopic diagnosis and cervical pathology was matched in 1492 (93.5%). Agreement of colposcopy and cytology was found in 1022 pacientek (64.1%). False negatives of cytology in high grade lesions were in 36.4%.

Conclusion:
Strength of agreement between colposcopic diagnosis and cervical pathology was found to be very good while for cytology high percentage of false negative results was seen. Expert colposcopists and high quality standard cytopathologic and bioptic laboratories are necessary for nationwide cervical screening programmes.

Keywords:
cervical cancer, colposcopy, oncological cytology, histology, CIN, cone biopsy

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