Změny v angiogenezi placenty a jejich korelace s rozvojem intrauterinní růstové retardace plodu

Typ studie:
Přehledový článek.

Pracoviště:
Gynekologicko-porodnická klinika, 1. lékařská fakulta Univerzity Karlovy a Nemocnice Na Bulovce, Praha; Katedra fyziologie, Přírodovědecká fakulta Univerzity Karlovy, Praha; Klinika dětského a dorostového lékařství, 1. lékařská fakulta Univerzity Karlovy a Všeobecná fakultní nemocnice, Praha.

Úvod:
Intrauterinní růstová retardace plodu (IUGR) je jeden z největších problémů současného porodnictví. Incidence se pohybuje kolem 3–10 % podle typu studované populace a vybraných kritérií. Nejvíce používanou definicí je váha plodu pod 10. percentilem vzhledem ke gestačnímu věku. Část autorů definuje IUGR pod 5. nebo 3. percentil. Jakýkoli zásah do vývoje cévního zásobení placenty může mít kritický dopad na růst a vývoj plodu. Omezená uteroplacentární perfuze je pak nejčastější příčinou IUGR. Vznik IUGR může být také odrazem poruchy prodlužování, větvení a dilatace kapilár placenty.

Metodika:
Tento přehledový článek shrnuje aktuální informace týkající se změn v placentární angiogenezi a jejich vlivu na rozvoj IUGR.

Závěr:
Cílem je shrnout současné znalosti týkající se mechanismu vývoje vaskulárního zásobení placenty za fyziologických podmínek a za podmínek vedoucí k rozvoji IUGR.

Klíčová slova:
intrauterinní růstová retardace plodu, růstové faktory, placenta, váha plodu, angiogeneze

Autoři: P. Bolehovská ¹; B. Sehnal ¹; D. Driák ¹ ; M. Halaška ¹; M. Magner ³; J. Novotný ²; I. Švandová
Působiště autorů: Department of Gynaecology and Obstetrics, 1st Faculty of Medicine, Charles Universityand Hospital Na Bulovce, Prague ¹; Department of Physiology, Faculty of Science, Charles University, Prague ²; Department of Children and Adolescent Medicine, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague ³
Vyšlo v časopise: Ceska Gynekol 2015; 80(2): 144-150

Souhrn

Typ studie:
Přehledový článek.

Metodika:
Tento přehledový článek shrnuje aktuální informace týkající se změn v placentární angiogenezi a jejich vlivu na rozvoj IUGR.

Závěr:
Cílem je shrnout současné znalosti týkající se mechanismu vývoje vaskulárního zásobení placenty za fyziologických podmínek a za podmínek vedoucí k rozvoji IUGR.

Klíčová slova:
intrauterinní růstová retardace plodu, růstové faktory, placenta, váha plodu, angiogeneze

Zdroje

1. Allaire, AD., Ballenger, KA., Wells, SR., et al. Placental apoptosis in preeclampsia. Obstet Gynecol, 2000, 96, p. 271–276.

2. Bahado-Singh, RO., Kovanci, E., Jeffres, A., et al. The Doppler cerebroplacental ratio and perinatal outcome in intrauterine growth restriction. Am J Obstet Gynecol, 1999, 180, p. 750–756.

3. Bamberg, C., Kalache, KD. Prenatal diagnosis of foetal growth restriction. Semin Foetal Neonatal Med, 2004, 9, p. 387–394.

4. Barker, DJP., Osmond, C., Forsen, TJ., et al. Maternal and social origins of hypertension. Hypertension, 2007, 50, p. 565–571.

5. Baschat, AA. Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction. Ultrasound Obstet Gynecol, 2011, 37, p. 501–514.

6. Benirschke, K., Kaufmann, P. Pathology of the human placenta. 4th ed. New York: Springer Verlag, 2000, 947, p. 13.

7. Bernstein, I., Gabbe, SG. Intrauterine growth restriction. In Gabbe, SG., Niebyl, JR., Simpson, JL., Annas, GJ., et al., eds. Obstetrics: normal and problem pregnancies. 3rd ed., New York: Churchill Livingstone, 1996, p. 863–886.

8. Brown, HL., Miller, JM. Jr., Gabert, HA., et al. Ultrasonic recognition of the small-for-gestational-age fetus. Obstet Gynecol, 1987, 69, p. 631–635.

9. Creasy, RK., Resnik, R. Intrauterine growth restriction. In Creasy RK, Resnik R, eds. Maternal-fetal medicine: principles and practice. 3rd ed., Philadelphia: Saunders, 1994, p. 558–574.

10. Cunningham, FG., Mac Donalld, PC., Grant, NF., et al. Fetal growth restriction. In Cunningham, FG., et al. Williams Obstetrics. 20th ed. Stamford: Conn. Appleton & Lange, 1997, p. 839–854.

11. Čech, E., Hájek, Z., Maršál, K., Srp, B., et al. Porodnictví, 2. vydání. Praha: Grada Publishing, 2006, s. 216–219.

12. DiFederico, E., Genbacev, O., Fisher, SJ. Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol, 1999, 155, p. 293–301.

13. Franco, C., Walker, M., Robertson, J., et al. Placental infarction and thrombophilia. Obstet Gynecol, 2011, 117, p. 929–934.

14. Fu, J., Olofsson, P. Fetal ductus venosus, middle cerebral artery and umbilical artery flow responses to uterine contractions in growth-restricted human pregnancies. Ultrasound Obstet Gynecol, 2007, 30, p. 867–873.

15. Furukawa, S., Kuroda, Y., Sugiyama, A. A comparison of the histological structure of the placenta in experimental animals.J Toxicol Pathol, 2014, 27, p. 11–18.

16. Gardosi, J. New definition of small for gestational age based on fetal growth potential. Horm Res, 2006, 65 (suppl 3), p. 15–18.

17. Gramellini, D., Folli, MC., Raboni, S., et al. Cerebral-umbilical Doppler ratio as a predictor of adverse perinatal outcome. Obstet Gynecol, 1992, 79, p. 416–420.

18. Gude, NM., Roberts, CT., Kalionis, B., King, RG. Growth and function of the normal human placenta. Thromb Res, 2004, 114, p. 397–407.

19. Hadlock, FP., Deter, RL., Harrist, RB., et al. A date-independent predictor of intrauterine growth retardation: femur length/abdominal circumference ratio. AJR Am J Roentgenol, 1983, 141, p. 979–984.

20. Herr, F., Ball, N., Widmer-Tesce, R., et al. How to stud placental vascular development? Theriogenology, 2010, 73, p. 817–827.

21. Hofstaetter, C., Gudmundsson, S., Dubiel, M., Mar-sal, K. Ductus venosus velocimetry in high-risk pregnancies. Eur J Obstet Gynecol Reprod Biol, 1996, 70, p. 135–140.

22. Hung, TH., Skepper, JN., Charnock-Jones, DS., et al. Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res, 2002, 90, p. 1274–1281.

23. Chen, CP., Bajoria, R., Aplin, JD. Decreased vascularization and cell proliferation in placentas of intrauterine growth-restricted fetuses with abnormal umbilical artery flow velocity waveforms. Am J Obstet Gynecol, 2002, 187, p. 764–769.

24. Ishihara, N., Matsuo, H., Murakoshi, H., et al. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol, 2002, 186, p. 158–166.

25. Jackson, MR., Walsh, AJ., Morrow, RJ., et al. Reduced placental villous tree elaboration in small-for-gestational-age pregnancies: relationship with umbilical artery Doppler waveforms. Am J Obstet Gynecol, 1995, 172, p. 518–525.

26. Jensen, A., Garnier, Y., Berger, R. Dynamics of fetal circulatory responses to hypoxia and asphyxia. Eur J Obstet Gynecol Reprod Biol, 1999, 84, p. 155–172.

27. Kaponis, AL., Harada, T., Makrydimas, G., et al. The importance of venous Doppler velocimetry for evaluation of intrauterine growth restriction. J Ultrasound Med, 2011, 30, p. 529–545.

28. Kaufmann, P., Mayhew, TM., Charnock-Jones, DS. Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy. Placenta, 2004, 25, p. 114–126.

29. Khare, M., Paul, S., Konje, JC. Variation in Doppler indices along the length of the cord from the intraabdominal to the placental insertion. Acta Obstet Gynecol Scand, 2006, 85, p. 922–928.

30. Kingdom, J., Adriana and Luisa Castallucci Award Lecture 1997. Placental pathology in obstetrics: adaptation or failure of the villous tree? Placenta, 1998, 19, p. 347–351.

31. Krebs, C., Macara, LM., Leiser, R., et al. Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree. Am J Obstet Gynecol, 1996, 175, p. 1534–1542.

32. Lausman, AL., McCarthy, FP., Walker, M., Kingdom, J. Screening, diagnosis, and management of intrauterine growth restriction. J Obstet Gynaecol Can, 2012, 34, p. 17–28.

33. Lecarpentier, E., Cordier, AG., Proulx, F., et al. Hemo-dynamic impact of absent or reverse end-diastolic flow in the two umbilical arteries in growth-restricted fetuses. PLoS One, 2013, 8(11):e81160.

34. Lindqvist, PG., Molin, J. Does antenatal identification of small-for-gestational age fetuses significantly improve their outcome? Ultrasound Obstet Gynecol, 2005, 25, p. 258–264.

35. Lubchenko, LO., Hansman, C., Dressler, M., Boyd, D. Intrauterine growth as estimated from lifeborn birth-weight data at 24 to 42 weeks of gestation. Pediatrics, 1963, 32, p. 793–800.

36. Maulik, D., Mundy, D., Heitmann, E. Evidence-based approach to umbilical artery Doppler fetal surveillance in high-risk pregnancies: an update. Clin Obstet Gynecol, 2010, 53, p. 869–878.

37. Mayhew, TM., Charnock-Jones, DS., Kaufmann, P. Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies. Placenta, 2004, 25, p. 127–139.

38. Mayhew, TM., Manwani, R., Ohadike, C., et al. The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distance and villous membrane diffusive conductances. Placenta, 2007, 28, p. 233–238.

39. Neerhof, MG. Causes of intrauterine growth restriction. Clin Perinatol, 1995, 22, p. 375–385.

40. Nylund, L., Lunell, NO., Lewander, R., Sarby, B. Uteroplacental blood flow index in intrauterine growth retardation of fetal or maternal origin. Br J Obstet Gynaecol, 1983, 90, p. 16–20.

41. Ott, WJ. The diagnosis of altered fetal growth. Obstet Gynecol Clin North Am, 1988, 15, p. 237–263.

42. Peleg, D., Kennedy, C., Hunter, SK. Intrauterine growth restriction: identification and management. Am Fam Physician, 1998, 58, p. 453–460.

43. Proctor, LK., Toal, M., Keating, S., et al. Placental size and the prediction of severe early-onset intrauterine growth restriction in women with low pregnancy-associated plasma protein-A. Ultrasound Obstet Gynecol, 2009, 34, p. 274–282.

44. Proctor, LK., Whittle, WL., Keating, S., et al. Pathologic basis of echogenic cystic lesions in the human placenta: role of ultrasound-guided wire localization. Placenta, 2010, 31, p. 1111–1115.

45. Regnault, TR., Galan, HL., Parker, TA., et al. Placental development in normal and compromised pregnancies: a review. Placenta, 2002 (suppl A), 23, p. 119–129.

46. Toal, M., Keating, S., Machin, G., et al. Determinants of adverse perinatal outcome in high-risk women with abnormal uterine artery Doppler images. Am J Obstet Gynecol, 2008, 198, p. 330.

47. Unterscheider, J., Daly, S., Geary, MP., et al. Definition and management of fetal growth restriction: a survey of contemporary attitudes. Eur J Obstet Gynecol Reprod Biol, 2014, 174, p. 41–45.

48. Wright, J., Morse, K., Kody, S., Francis, A. Audit of fundal height measurement plotted on customised growth charts. MIDIRS Midwifery Digest, 2006, 16, p. 341–345.