Smoking in pregnancy – negative impacton mother and child Opinions on nicotine substitution

Česká verzia

Authors: K. Adamcová ¹; M. Dušková ²; A. Pařízek ¹
Authors place of work: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. ¹; Endokrinologický ústav, Praha, ředitelka doc. RNDr. B. Bendlová, CSc. ²
Published in the journal: Ceska Gynekol 2015; 80(4): 264-270

Summary

Cigarette smoking (tobacco abuse) is legal in the Czech Republic and use of this drug is more or less tolerated there.

Argumentation about economic benefits of the production and sale of tobacco products in this country is not responsibly given in context with the level of damage to health. The state does not consistently take into action restrictive measures to prevent this negative phenomenon. Even the medical community adopts an indifferent attitude.

Although there have been found countless hard evidence about the harmful effects of smoking on the mother and fetus/baby.

Even very small amounts of cigarettes has a negative impact on mother, placental perfusion and ultimately the child. The aim of the article is to describe the pathophysiology of tobacco abuse on mother and baby and to simultaneously open a space for discussion about the treatment of smokers during their pregnancy.

Keywords:
smoking, pregnancy, fetus, metabolism, nicotine substitution

Zdroje

1. Anderka, M., Romit, PA., Sun, L., et al. Patterns of tobacco exposure before and during pregnancy, Acta Obstet Gynecol Scand, 2010, 89, p. 505–514.

2. Benowitz, N., Dempsey, D. Pharmacotherapy for smoking cessation during pregnancy. Nicotine Tob Res, 2004, 6 (Suppl. 2), p. 189–202.

3. Cressman, AM., Pupco, A., Kim, E., et al. Smoking cessation therapy during pregnancy. Canad Fam Physician, 2012, 58, 5, p. 525–527.

4. Crha, I., Hrubá, D. Kouření a reprodukce. 1. vyd., Brno: Masarykova univerzita, 2000, 54 s., ISBN 80-210-2284-1.

5. Divers, WA. Jr., Wilkes, MM., Babaknia, A., Yen, SS. Maternal smoking and elevation of catecholamines and metabolites in the amniotic fluid. Am J Obstet Gynecol, 1981, 141(6), p. 625–628.

6. Dušková, M., Hruškovičová, H., Simůnková, K., et al. The effects of smoking on steroid metabolism and fetal programming. J Steroid Biochem Mol Biol, 2014, 139, p. 138–143.

7. Gao, YJ., Lu, C., Su, LY., et al. Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide. Br J Pharmacol, 2007, 151, p. 323–331.

8. Gilliland, FD., Berhane, K., McConnell, R., et al. Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax, 2000, 55, p. 271–276.

9. Gilliland, FD., Li, YF., Peters, JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med, 2001, 163, p. 429–436.

10. Glynn, DA., Cryan, JF., Kent, P., et al. Update on smoking cessation therapies. Adv Ther, 2009, 26, p. 369–382.

11. Gollasch, M., Dubrovska, G. Paracrine role for periadventitial adipose tissue in the regulation of arterial tone. Trends Pharmaco. Sci, 2004, 25, p. 647–653.

12. Gunes, T., Koklu, E., Yikilmaz, A., et al. Influence of maternal smoking on neonatal aortic intima–media thickness, serum IGF-I and IGFBP-3 levels. Eur J Pediatr, 2007, 166(10), p. 1039–1044. Epub 2007 Jan 4.

13. Hanrahan, JP., Tager, IB., Segal, MR., et al. The effect of maternal smoking during pregnancy on early infant lung function. Am Rev Respir Dis, 1992, 145(5), p. 1129–1135.

14. Hart, R., Sloboda, DM., Doherty, DA., et al. Prenatal determinants of uterine volume and ovarian reserve in adolescence. J Clin Endocrinol Metab, 2009, 94(12), p. 4931–4937.

15. Hillebrand, JJ., de Wied, D., Adan, RA. Neuropeptides, foodintake and body weight regulation: a hypothalamic focus. Peptides. 2002, 23, p. 2283–2306.

16. Holloway, AC., Lim, GE., Petrik, JJ., et al. Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes. Diabetologia, 2005, 48, p. 2661–2666.

17. Hrubá, D. Kouření a reprodukce, 2000, http://www.med.muni.cz/prelek/zdravi/clanky/hruba/repro.html.

18. Hrubá, D. Riziko kouření v těhotenství se stále podceňuje. Tolerovat kouření v těhotenství je neodborné a neetické. Prak Gynek, 2011, 15(1), s. 34–39.

19. Hussein, J., Farkas, S., MacKinnon, Y., et al. Nicotine dose-concentration relationship and pregnancy outcomes in rat: biologic plauzibility and implications for future research. Toxicol Applied Pharmacol, 2007, 218, p. 1–10.

20. Jedrychowski, W., Flak, E. Maternal smoking during pregnancy and postnatal exposure to environmental tobacco smoke as predisposition factors to acute respiratory infections. Environmental Health Perspectives, 1997, 105(3), p. 302–306.

21. Kalra, SP., Dube, MG., Pu, S., et al. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev, 1999, 20, p. 68–100.

22. Kandel, DB., Udry, JR. Prenatal effects of maternal smoking on daughters‘ smoking: nicotine or testosterone exposure? Am J Public Health, 1999, 89(9), p. 1377–1383.

23. Kerkhof, GF., Leunissen, RW., Willemsen, RH., et al. Influence of preterm birth and birth size on gonadal function in young men. J Clin Endocrinol Metab, 2009, 94(11), p. 4243–4250.

24. Králíková, E., Bajerová, J., Raslová, N., et al. Smoking and pregnancy: prevalence, knowledge, antrophometry, risk communication. PMR, 2005, 106(2), p. 195–200.

25. Kurahashi, N., Kasai, S., Shibata, T., et al. Parental and neonatal risk factors for cryptorchidism. Med Sci Monit, 2005, 11(6), p. 274–283.

26. Lackmann, GM., Salzberger, U., Tollner, U., et al. Metabolites of a tobacco-specific carcinogen in urine from newborns. J Natl Cancer Inst, 1999, 91, p. 459–465.

27. Lassen, TH., Madsen, M., Skovgaard, LT., et al. Maternal use of nicotine replacement therapy during pregnancy anf offspring birthweight: a study within the Danish National Birth Cohort. Paed Perinat Epidemiol, 2010, 24, p. 272–281.

28. Lawrence, J., Xiao, D., Xue, Q., et al. Prenatal nicotine exposure increases heart susceptibility to ischemia/reperfusion injury in adult offspring. J Pharmacol Exp Ther, 2008, 324, p. 331–341.

29. Main, KM., Skakkebaek, NE., Toppari, J. Cryptorchidism as part of the testicular dysgenesis syndrome: the environmental connection. Endocr Dev, 2009, 14, p. 167–173.

30. Mattsson, K., Källén, K., Longnecker, MP., et al. Maternal smoking during pregnancy and daughters‘ risk of gestational diabetes and obesity. Diabetologia, 2013, 56(8), p. 1689–1695.

31. Melville, NA. Smoking during pregnancy increases risk for preterm birth. Preventive Medicine 2010, Medscape. Feb 26

32. Mendelsohn, C., Gould, G., Oncken, C. Management of smoking in pregnant women. Austr Fam Physician, 2014, 43, p. 46–51.

33. Mitchell, EA., Milerad, J. Smoking and the sudden infantdeath syndrome. Rev Environ Health, 2006, 21, p. 81–103.

34. Montgomery, SM., Ekbom, A. Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort. BMJ, 2002, p. 324–326.

35. Nechanská, B., Mravčík, V., Sopko, B., Velebil, P. Rodičky užívající alkohol, tabák a nelegální drogy. Čes Gynek, 2012, 77(5), s. 457–469.

36. Newman, MB., Shytle, RD., Sanberg, PR. Locomotor behavioral effects of prenatal and postnatal nicotine exposure in rat offspring. Behav Pharmacol, 1999, 10, p. 699–706.

37. Okuyemi, KS., Ahluwalia, JS., Harris, KJ. Pharmacotherapy of smoking cessation. Arch Fam Med, 2000, 9, p. 270–281.

38. Ontario Medical Association (OMA). Rethinking stop-smoking medications: treatment myths and medical realities [update 2008] Ontario. Medical Rev, 2008, 75, p. 22–34.

39, Peters, MJ., Morgan, LC. The pharmacotherapy of smoking cessation. Med J Aust, 2002, 176, p. 486–490.

40. Richthoff, J., Elzanaty, S., Rylander, L., et al. Association between tobacco exposure and reproductive parameters in adolescent males. Int J Androl, 2008, 31(1), p. 31–39.

41. Shah, T., Sullivan, K., Carter, J. Sudden infant death syndrome and reported maternal smoking during pregnancy. Am J Public Health, 2006, 96(10), p. 1757–1759.

42. Skorge, TD., Eagan, TM., Eide, GE., et al. The adult incidence of asthma and respiratory symptoms by passive smoking in uterus or in childhood. Am J Respir Crit Care Med, 2005, 172, p. 61–66.

43. Slotkin, TA., Saleh, JL., McCook, EC., Seidler, FJ. Impaired cardiac function during postnatal hypoxia in rats exposed to nicotine prenatally: implications for perinatal morbidity and mortality, and for sudden infant death syndrome. Teratology, 1997, 55, p. 177–184.

44. Soares, SR., Mělo, MA. Cigarette smoking and IVF. Obstet Gynec, 2008, 3(4), p. 555–563.

45. Somm, E., Schwitzgebel, VM., Vauthay, DM., et al. Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life. Endocrinology, 2008, 149, p. 6289–6299.

46. Suarez, A., Rico, F., Clavero-Nunez, JA., Garcia-Barreno, P. Amniotic fluid catecholamine metabolites in maternal smoking. Gynecol Obstet Invest, 1990, 30(3), p. 143–146.

47. Tong, VT., England, LJ., Dietz, PM., Asare, LA. Smoking patterns and use of cessation interventions during pregnancy. Am J Prev Med, 2008, 35, p. 327–333.

48. Varvarigou, AA., Petsali, M., Vassilakos, P., Beratis, NG. Increased cortisol concentrations in the cord blood of newborns whose mothers smoked during pregnancy. J Perinat Med, 2006, 34(6), p. 466–470.

49. Vaz, LR., Leonardi-Bee, J., Aveyard, P., et al. Factors associated with smoking cessation in early and late pregnancy in the smoking, nicotine, and pregnancy trial: A Trial of Nicotine Replacement Therapy. Nicotine Tob Res, 2014, 16(4), p. 381–389.

50. Wideroe, M., Vik, T., Jacobsen, G., Bakketeig, LS. Does maternal smoking during pregnancy cause childhood overweight? Paediatr Perinat Epidemiol, 2003, 17, p. 171–179.

51. Wilding, JP. Neuropeptides and appetite control. Diabet Med, 2002, 19, p. 619–627.