Possible effects on the liberation of alaptid from dermal semisolid preparations

Summary

The paper examines the effects of routinely used humectants of glycerol (GL) and propylene glycol (PG) on the liberation of alaptid (ALA) from 3% (m/m) chitosan (CHIT) hydrogels in comparison with the liberation of alaptid (ALA) from cream. The contents of GL and PG in the individual hydrogels were 5%, 10%, 15% (m/m). Alaptid is a regeneratively acting synthetic derivative of prolyl-leucyl-glycin amide, which is for the time being used in veterinary medicine. Its content in the hydrogels and cream under study was 1% (m/m). The experiments were performed in vitro in a tempered permeating apparatus. The amount of the released ALA was measured spectrophotometrically at 212nm, 14 day after the preparation of the individual chitosan hydrogels and cream. ALA was liberated in the following amounts: 14.06% was released from cream; 36.54% from hydrogel containing 5% GL (m/m); 37.85% from hydrogel with 5% PG (m/m); 38.37% from hydrogel not containing GL and PG; 40.71% from hydrogel containing 15% GL (m/m); 41.21% from hydrogel with 10% GL (m/m); 42.72% ALA was released from hydrogel with 10% PG (m/m); 43.78% from hydrogel with 15% PG (m/m). It can be concluded that the presence of GL and PG exerted effects on liberation of ALA from dermal semisolid preparations.

Key words:
alaptid – liberation – chitosan – glycerol – propylene glycol