Influence of the kind of polymer on chlorhexidine liberation from hydrogel

Česká verzia

Authors: Z. Vitková; M. Žabka; P. Herdová
Authors place of work: Univerzita Komenského Bratislava, Farmaceutická fakulta, Katedra galenickej farmácie, Slovenská republika
Published in the journal: Čes. slov. Farm., 2010; 59, 123-126
Category: Původní práce

Summary

The aim of this paper was to select the optimal polymer for the formulation of the model drug chlorhexidine dichloride into hydrogel. Two types of biopolymers were used, one of the modified polymers was of herbal origin taken from the group of cellulose derivates – methylcellulose, hydroxyethylcellulose and hydroxypropylcellulose, and the other was of animal origin – chitosan of a medium and a high molecular weight. The polymers were used in a concentration of 2.5% (m/m). Drug liberation was evaluated by the percentage of the drug released into the physiological solution. In addition, the rheological properties of hydrogels were evaluated. Judging the drug release from chitosan hydrogels, the one with the medium molecular weigh was found to be optimal. Contrary to that, from among the hydrogels prepared on the basis of cellulose derivatives, the optimal one was hydroxyethylcellulose hydrogel.

Key words:
chlorhexidinedichloride – polymers – hydrogel – liberation – rheological properties

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