Neuromuscular diseases and pregnancy
Authors:
E. Vlčková; S. Voháňka; A. Rajdová; J. Bednařík
Authors place of work:
Neurologická klinika LF MU a FN Brno
Published in the journal:
Cesk Slov Neurol N 2019; 82(3): 252-264
Category:
Minimonografie
doi:
https://doi.org/10.14735/amcsnn2019252
Summary
Pregnancy may significantly change the course of several neuromuscular diseases and have an impact on their therapy (especially some immunosuppressive agents commonly used for the therapy of immune-mediated inflammatory diseases are contraindicated). On the contrary, many neuromuscular diseases may negatively influence pregnancy and increase the occurrence of some complications of pregnancy and delivery. Several neuromuscular diseases thus significantly increase the incidence of spontaneous abortion, preterm birth, abnormal fetal position/ presentation, increased postpartum hemorrhage, and the rate of cesarean sections or operative vaginal deliveries using pliers or vacuum extractor. Some of neuromuscular diseases may also have an important impact on a fetus, e. g. the diseases which potentially decrease the oxygen saturation of the mother’s arterial blood may lead to the intrauterine fetal hypoxia. Furthermore, some diseases may be transmitted to the newborn, either genetically or by the transplacental transmission of antibodies on fetus. This minimonography summarizes the current knowledge on mutual relationship of pregnancy and the most frequent groups of neuromuscular diseases – myasthenia gravis, inflammatory myopathies, muscular dystrophies, motor neuron diseases, Guillain-Barre syndrome and chronic inflamatory demyelinating neuropathy, hereditary neuropathies and the most frequent mononeuropathies related to pregnancy (carpal tunnel syndrome, Bell’s palsy and some other traumatic or compressive postpartum lesions of the peripheral nerves in pelvic region or in lower extremities). If available, the recommendations upon the follow-up and management of patients with neuromuscular diseases during and after pregnancy and delivery are also mentioned.
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Keywords:
pregnancy – neuromuscular diseases – immunosuppressive agents – myasthenia gravis – myositis – muscular dystrophies – motor neuron disease – Guillain-Barre syndrome – hereditary sensory and motor neuropathy – carpal tunnel syndrome – mononeuropathies
Zdroje
1. Špalek P. Myasténia gravis a žena: tehotenstvo, pôrod, puerpérium a tranzitórna neonatálna myasténia. Neurol praxi 2014; 15(6): 296– 299.
2. Norwood F, Dhanjal M, Hill M et al. Myasthenia in pregnancy: best practice guidelines from a U.K. multispecialty working group. J Neurol Neurosurg Psychiatry 2014; 85(5): 538– 543. doi: 10.1136/ jnnp-2013-305
572.
3. Plauché WC. Myasthenia gravis in mothers and their newborns. Clin Obstet Gynecol 1991; 34(1): 82– 99.
4. Batocchi AP, Majolini L, Evoli A et al. Course and treatment of myasthenia gravis during pregnancy. Neurology 1999; 52(3): 447– 452.
5. Djelmis J, Sostarko M, Mayer D et al. Myasthenia gravis in pregnancy: report on 69 cases. Eur J Obstet Gynecol Reprod Biol 2002; 104(1): 21– 25.
6. Ducci RD, Lorenzoni PJ, Kay CS et al. Clinical follow-up of pregnancy in myasthenia gravis patients. Neuromuscul Disord 2017; 27(4): 352– 357. doi: 10.1016/ j.nmd.2017.01.021.
7. ÚZIS ČR. Potraty 2014– 2015. Praha: ÚZIS ČR 2017.
[online]. Dostupné z URL: www.uzis.cz/ publikace/ potraty-2014– 2015.
8. Zeitlin J, Szamotulska K, Drewniak N et al. Preterm births time trends in Europe: study of 19 countries. BJOG 2013; 120(11): 1356– 1365. doi: 10.1111/ 1471-0528.12281.
9. Betrán AP, Ye J, Moller AB et al. The increasing trend in caesarean section rates: global, regional and national estimates: 1990– 2014. PLoS One 2016; 11(2): e0148343. doi: 10.1371/ journal.pone.0148343.
10. ÚZIS ČR. Rodička a novorozenec 2014– 2015. [online]. Praha: ÚZIS ČR 2017. Dostupné z URL: www.uzis.cz/ katalog/ zdravotnicka-statistika/ rodicka-novorozenec.
11. Jeon J, Na S. Vacuum extraction vaginal delivery: current trend and safety. Obstet Gynecol Sci 2017; 60(6): 499– 505. doi: 10.5468/ ogs.2017.60.6.499.
12. Hacohen Y, Jacobson LW, Byrne S et al. Fetal acetylcholine receptor inactivation syndrome: a myopathy due to maternal antibodies. Neurol Neuroimmunol Neuroinflamm 2014; 2(1): e57. doi: 10.1212/ NXI.0000000000000057.
13. Liu FC, Kuo CF, See LC et al. Familial aggregation of myasthenia gravis in affected families: a population-based study. Clin Epidemiol 2017; 9: 527– 535. doi: 10.2147/ CLEP.S146617.
14. Hoff JM, Daltveit AK, Gilhus NE. Artrogryposis multiplex congenita – a rare fetal condition caused by maternal myasthenia gravis. Acta Neurol Scand 2006; 183 (Suppl): 26– 27. doi: 10.1111/ j.1600-0404.2006.00610.x.
15. Midelfart Hoff J, Midelfart A. Maternal myasthenia gravis: a cause for arthrogryposis multiplex congenita. J Child Orthop 2015; 9(6): 433– 435. doi: 10.1007/ s11832-015-0690-8.
16. Gerosa M, Meroni PL, Cimaz R. Safety considerations when prescribing immunosuppression medication to pregnant women. Expert Opin Drug Saf 2014; 13(12): 1591– 1599. doi: 10.1517/ 14740338.2014.951326.
17. Levy RA, de Jesús GR, de Jesús NR et al. Critical review of the current recommendations for the treatment of systemic inflammatory rheumatic diseases during pregnancy and lactation. Autoimmun Rev 2016; 15(10): 955– 963. doi: 10.1016/ j.autrev.2016.07.014.
18. Mateus S, Malheiro M, Santos MP et al. Dermatomyositis onset in the puerperium period. BMJ Case Rep 2015; 2015. pii: bcr2015211025. doi: 10.1136/ bcr-2015-211025.
19. Nagy-Vincze M, Vencovsky J, Lundberg IE et al. Pregnancy outcome in idiopathic inflammatory myopathy patients in a multicenter study. J Rheumatol 2014; 41(12): 2492– 2494. doi: 10.3899/ jrheum.140438.
20. Váncsa A, Ponyi A, Constantin T et al. Pregnancy outcome in idiopathic inflammatory myopathy. Rheumatol Int 2007; 27(5): 435– 439. doi: 10.1007/ s00296-006-0239-8.
21. Mintz G. Dermatomyositis. Rheum Dis Clin North Am 1989; 15(2): 375– 382.
22. Gutiérrez G, Dagnino R, Mintz G. Polymyositis/ dermatomyositis and pregnancy. Arthritis Rheum 1984; 27(3): 291– 294.
23. Silva CA, Sultan SM, Isenberg DA. Pregnancy outcome in adult-onset idiopathic inflammatory myopathy. Rheumatology (Oxford) 2003; 42(10): 1168– 1172. doi: 10.1093/ rheumatology/ keg318.
24. Kolstad KD, Fiorentino D, Li S et al. Pregnancy outcomes in adult patients with dermatomyositis and polymyositis. Semin Arthritis Rheum 2018; 47(6): 865– 869. doi: 10.1016/ j.semarthrit.2017.11.005.
25. Attarian S, Salort-Campana E, Nguyen K et al. Recommendations for the management of facioscapulohumeral muscular dystrophy in 2011. Rev Neurol (Paris) 2012; 168(12): 910– 918. doi: 10.1016/ j.neurol.2011.11.008.
26. Tawil R, van der Maarel S, Padberg GW et al. 171st ENMC international workshop: standards of care and management of facioscapulohumeral muscular dystrophy. Neuromuscul Disord 2010; 20(7): 471– 475. doi: 10.1016/ j.nmd.2010.04.007.
27. Argov Z, de Visser M. What we do not know about pregnancy in hereditary neuromuscular disorders. Neuromuscul Disord 2009; 19(10): 675– 679. doi: 10.1016/ j.nmd.2009.07.004.
28. Srebnik N, Margalioth EJ, Rabinowitz R et al. Ovarian reserve and PGD treatment outcome in women with myotonic dystrophy. Reprod Biomed Online 2014; 29(1): 94– 101. doi: 10.1016/ j.rbmo.2014.03.013.
29. Johnson NE, Hung M, Nasser E et al. The impact of pregnancy on myotonic dystrophy: a registry-based study. J Neuromuscul Dis 2015; 2(4): 447– 452. doi: 10.3233/ JND-150095.
30. Hoogerwaard EM, van der Wouw PA, Wilde AA et al. Cardiac involvement in carriers of Duchenne and Becker muscular dystrophy. Neuromuscul Disord 1999; 9(5): 347– 351.
31. Darras BT, Miller DT, Urion DK. Dystrophinopathies. In: Adam MP, Ardinger HH, Pagon RA et al (eds). GeneReviews®. Seattle (WA): University of Washington 1993– 2017. [online]. Available from URL: https: / / www.ncbi.nlm.nih.gov/ books/ NBK1119.
32. Rudnik-Schöneborn S, Zerres K. Outcome in pregnancies complicated by myotonic dystrophy: a study of 31 patients and review of the literature. Eur J Obstet Gynecol Reprod Biol 2004; 114(1): 44– 53. doi: 10.1016/ j.ejogrb.2003.11.025.
33. Geifman-Holtzman O, Bernstein IM, Capeless EL et al. Increase in fetal breech presentation in female carriers of Duchenne muscular dystrophy. Am J Med Genet 1997; 73(3): 276– 278.
34. Awater C, Zerres K, Rudnik-Schöneborn S. Pregnancy course and outcome in women with hereditary neuromuscular disorders: comparison of obstetric risks in 178 patients. Eur J Obstet Gynecol Reprod Biol 2012; 162(2): 153– 159. doi: 10.1016/ j.ejogrb.2012.02.020.
35. Elsheikh BH, Zhang X, Swoboda KJ et al. Pregnancy and delivery in women with spinal muscular atrophy. Int J Neurosci 2017; 127(11): 953– 957. doi: 10.1080/ 00207454.2017.1281273.
36. Rudnik-Schöneborn S, Zerres K, Ignatius J et al. Pregnancy and spinal muscular atrophy. J Neurol 1992; 239(1): 26– 30.
37. Scalco RS, Vieira MC, da Cunha Filho EV et al. Amyotrophic lateral sclerosis and riluzole use during pregnancy: a case report. Amyotroph Lateral Scler 2012; 13(5): 471– 472. doi: 10.3109/ 17482968.2012.673
171.
38. Rooney JP, Visser AE, D‘Ovidio F et al. A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR. Neurology 2017; 89(12): 1283– 1290. doi: 10.1212/ WNL.0000000000004390.
39. Auger N, Quach C, Healy-Profitós J et al. Early predictors of Guillain-Barré syndrome in the life course of women. Int J Epidemiol 2018; 47(1): 280– 288. doi: 10.1093/ ije/ dyx181.
40. Sax TW, Rosenbaum RB. Neuromuscular disorders in pregnancy. Muscle Nerve 2006; 34(5): 559– 571. doi: 10.1002/ mus.20661.
41. Pacheco LD, Saad AF, Hankins GD et al. Guillain-Barré syndrome in pregnancy. Obstet Gynecol 2016; 128(5): 1105– 1110. doi: 10.1097/ AOG.0000000000001716.
42. Chan LY, Tsui MH, Leung TN. Guillain-Barré syndrome in pregnancy. Acta Obstet Gynecol Scand 2004; 83(4): 319–325.
43. Nelson LH, McLean WT Jr. Management of Landry-Guillain-Barré syndrome in pregnancy. Obstet Gynecol 1985; 65 (Suppl 3): 25– 29.
44. Luijckx GJ, Vles J, de Baets M et al. Guillain-Barré syndrome in mother and newborn child. Lancet 1997; 349(9044): 27.
45. Watson WJ, Katz VL, Bowes WA Jr. Plasmapheresis during pregnancy. Obstet Gynecol 1990; 76 (3 Pt 1): 451– 457.
46. Clark AL. Clinical uses of intravenous immunoglobulin in pregnancy. Clin Obstet Gynecol 1999; 42(2): 368– 380.
47. McCombe PA, McManis PG, Frith JA et al. Chronic inflammatory demyelinating polyradiculoneuropathy associated with pregnancy. Ann Neurol 1987; 21(1): 102– 104. doi: 10.1002/ ana.410210120.
48. Rudnik-Schöneborn S, Rohrig D, Nicholson G et al. Pregnancy and delivery in Charcot-Marie-Tooth disease type 1. Neurology 1993; 43(10): 2011– 2016.
49. Hoff JM, Gilhus NE, Daltveit AK. Pregnancies and deliveries in patients with Charcot-Marie-Tooth disease. Neurology 2005; 64(3): 459– 462. doi: 10.1212/ 01.WNL.0000150933.65709.96.
50. Padua L, Di Pasquale A, Pazzaglia C et al. Systematic review of pregnancy-related carpal tunnel syndrome. Muscle Nerve 2010; 42(5): 697– 702. doi: 10.1002/ mus.21910.
51. Padua L, Coraci D, Erra C et al. Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol 2016; 15(12): 1273– 1284. doi: 10.1016/ S1474-4422(16)30231-9.
52. Padua L, Aprile I, Caliandro P et al. Carpal tunnel syndrome in pregnancy: multiperspective follow-up of
untreated cases. Neurology 2002; 59(10): 1643– 1646.
53. Mondelli M, Rossi S, Monti E et al. Prospective study of positive factors for improvement of carpal tunnel syndrome in pregnant women. Muscle Nerve 2007; 36(6): 778– 783. doi: 10.1002/ mus.20863.
54. van Slobbe AM, Bohnen AM, Bernsen RM et al. Incidence rates and determinants in meralgia paresthetica in general practice. J Neurol 2004; 251(3): 294– 297. doi: 10.1007/ s00415-004-0310-x.
55. Holland J, Bernstein J. Bell‘s palsy. BMJ Clin Evid 2011; 2011. pii: 1204.
56. Monini S, Lazzarino AI, Iacolucci C et al. Epidemiology of Bell‘s palsy in an Italian health district: incidence and case-control study. Acta Otorhinolaryngol Ital 2010; 30(4): 198.
57. Phillips KM, Heiser A, Gaudin R et al. Onset of bell‘s palsy in late pregnancy and early puerperium is associated with worse long-term outcomes. Laryngoscope 2017; 127(12): 2854– 2859. doi: 10.1002/ lary.26569.
58. Katz A, Sergienko R, Dior U et al. Bell‘s palsy during pregnancy: is it associated with adverse perinatal outcome? Laryngoscope 2011; 121(7): 1395– 1398. doi: 10.1002/ lary.21860.
59. Ragupathy K, Emovon E. Bell‘s palsy in pregnancy. Arch Gynecol Obstet 2013; 287(1): 177– 178. doi: 10.1007/ s00404-012-2506-0.
60. Salinas RA, Alvarez G, Daly F et al. Corticosteroids for Bell‘s palsy (idiopathic facial paralysis). Cochrane Database Syst Rev 2010; 17(3): CD001942. doi: 10.1002/ 14651858.CD001942.pub4.
61. de Almeida JR, Al Khabori M, Guyatt GH
et al. Combined corticosteroid and antiviral treatment for Bell palsy: a systematic review and meta-analysis. JAMA 2009; 302(9): 985– 993. doi: 10.1001/ jama.2009.
1243.
62. Kofler M, Kronenberg MF. Bilateral femoral neuropathy during pregnancy. Muscle Nerve 1998; 21(8): 1106– 1110.
63. Wong CA, Scavone BM, Dugan S et al. Incidence of postpartum lumbosacral spine and lower extremity nerve injuries. Obstet Gynecol 2003; 101(2): 279– 288.
64. Adelman JU, Goldberg GS, Puckett JD. Postpartum bilateral femoral neuropathy. Obstet Gynecol 1973; 42(6): 845– 850.
65. Babayev M, Bodack MP, Creatura C. Common peroneal neuropathy secondary to squatting during childbirth. Obstet Gynecol 1998; 91 (5 Pt 2): 830– 832
Štítky
Detská neurológia Neurochirurgia NeurológiaČlánok vyšiel v časopise
Česká a slovenská neurologie a neurochirurgie
2019 Číslo 3
- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
- Fixní kombinace paracetamol/kodein nabízí synergické analgetické účinky
- Kombinace metamizol/paracetamol v léčbě pooperační bolesti u zákroků v rámci jednodenní chirurgie
- Tramadol a paracetamol v tlumení poextrakční bolesti
- Antidepresivní efekt kombinovaného analgetika tramadolu s paracetamolem
Najčítanejšie v tomto čísle
- Test mince v ruce k detekci předstírání oslabeného paměťového výkonu ve srovnání s mírnou kognitivní poruchou a s mírnou demencí u Alzheimerovy nemoci
- Neuromuskulární choroby a gravidita
- Měření terče zrakového nervu a sítnice pomocí optické koherentní tomografie u nově diagnostikované idiopatické intrakraniální hypertenze bez ztráty zraku
- Využití vakuově-kompresní terapie v léčbě syndromu karpálního tunelu jako součást fyzioterapie – pilotní studie