Fibroblasts – Known or Unknown Cells

Česká verzia

Authors: S. Brychtová ¹; M. Bezděková ¹; T. Brychta ²
Authors place of work: Laboratoř molekulární patologie a Ústav patologie LF UP, Olomouc ¹; Centrum klinických studií. Agentura Science Pro, spol. s r. o., Nestátní zdravotnické zařízení, Olomouc ²
Published in the journal: Čes.-slov. Patol., 46, 2010, No. 2, p. 29-32
Category: Přehledový článek

Summary

Fibroblasts form the main component of the cell tissue microenvironment, and their basic function is to maintain cell integrity and tissue homeostasis. Fibroblasts essentially participate in wound repair. Recently, increased interest has been focused on the role of fibroblasts in cancers, where they are involved in the ransformation of a tumour stroma, and via production of numbers of cytokines and growth factors participate in tumour progression. With regard to their impact in cancerogenesis, fibroblasts become a new target of cancer therapy.

Key words:
fibroblasts – stromal microenvironment – tumor progression

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