Úloha molekulárnej biológie pri diagnostike a monitoringu karcinómu prostaty

Štúdium molekulových markerov v rôznych neopláziách ako aj pri karcinóme prostaty je založené na analýze génov, ktoré sa spolupodieľajú na vzniku karcinómu. Boli sledované mutácie, amplifikácie a iné zmeny týchto génov alebo ich produktov, ktoré sú porovnávané s tradičnými prognostickými markermi. Tieto gény možno označiť ako onkogény, tumor supresorové gény alebo gény s inými významnými bunkovými funkciami. Štúdie karcinómu prostaty sú často limitované heterogenitou tohto nádoru. V predloženej práci predkladáme prehľad niektorých najčastejších diagnostických a prognostických molekulovo biologických markerov vyšetrovaných v súvislosti s karcinómom prostaty.

Kľúčové slová:
karcinóm prostaty – molekulárna biológia – molekulárne markery

Autoři: A. Zummerová ¹; D. Böhmer ²; J. Fillo ³; Ľudovít Danihel ⁴; Vanda Repiská ²
Působiště autorů: Department of Pathology and Forensic medicine, Health Care Surveillance Authority, Bratislava, Slovakia ¹; Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia ²; Department of Urology, Faculty Hospital, Bratislava, Slovakia ³; Department of Pathology, Faculty of Medicine, Comenius University, Bratislava, Slovakia ⁴
Vyšlo v časopise: Čes.-slov. Patol., 46, 2010, No. 4, p. 95-97
Kategorie: Vyzvaný článek

Souhrn

Kľúčové slová:
karcinóm prostaty – molekulárna biológia – molekulárne markery

Zdroje

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