Serrated adenomas and carcinomas of the colon

Česká verzia

Authors: Alena Chlumská ^1,2; Petr Martínek ²; Petr Mukenšnabl ¹; Michael Michal ^1,2; Michal Zámečník ^3,4
Authors place of work: Šiklův ústav patologie FN, Univerzita Karlova v Plzni, Česká republika ¹; Bioptická laboratoř s. r. o., Plzeň, Česká Republika ²; Agel a. s., Laboratoř patologie, Nový Jičín, Česká republika ³; Medirex Group Academy n. o., Bratislava, Slovenská republika ⁴
Published in the journal: Čes.-slov. Patol., 52, 2016, No. 1, p. 11-14
Category: Přehledový článek

Summary

Approximately 5 – 35 % of colorectal carcinomas arise through serrated carcinogenesis. The precursor of such carcinomas are serrated adenomas, which differ from conventional adenomas morphologically as well as genetically. Herein, we provide a basic overview of serrated lesions of the large intestine with the focus on histological diagnosis and molecular biology.

Keywords:
hyperplastic polyp – sessile serrated adenoma – traditional serrated adenoma – serrated carcinoma – serrated carcinogenesis

Zdroje

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