Hybridní nádory z obalů periferních nervů:
přehledový článek

Hybridní nádory z obalů periferních nervů jsou poměrně nedávno popsanými jednotkami. S postupujícím výzkumem bylo v této oblasti dosaženo značného množství důležitých poznatků, z nichž mnohé jsou významné i z klinického hlediska. V literatuře však dosud chybí kompexní souhrn tohoto tématu. V předkládaném přehledovém článku jsou probrány jednotlivé typy hybridních tumorů se zvláštním zaměřením na jejich morfologické a imunohistochemické vlastnosti, přičemž důraz je rovněž kladen na jejich vztah k nádorovým syndromům.

Klíčová slova:
Hybridní nádory z obalů periferních nervů – schwannom – perineuriom – neurofibrom – neurofibromatóza – schwannomatóza

Autoři: Michael Michal ^1,2; Dmitry V. Kazakov ¹; Michal Michal ¹
Působiště autorů: Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic ¹; Biomedical Center of the Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic ²
Vyšlo v časopise: Čes.-slov. Patol., 53, 2017, No. 2, p. 81-88
Kategorie: Přehledový článek

Souhrn

Klíčová slova:
Hybridní nádory z obalů periferních nervů – schwannom – perineuriom – neurofibrom – neurofibromatóza – schwannomatóza

Zdroje

1. Feany MB, Anthony DC, Fletcher CD. Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge. Histopathology 1998; 32(5): 405-410.

2. Zámečník M, Michal M. Perineurial cell differentiation in neurofibromas. Report of eight cases including a case with composite perineurioma-neurofibroma features. Pathol Res Pract 2001; 197(8): 537-544.

3. Nascimento AF, Fletcher CD. The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas. Am J Surg Pathol 2007; 31(9): 1363-1370.

4. Lazarus SS, Trombetta LD. Ultrastructural identification of a benign perineurial cell tumor. Cancer 1978; 41(5): 1823-1829.

5. Hirose T, Tani T, Shimada T, Ishizawa K, Shimada S, Sano T. Immunohistochemical demonstration of EMA/Glut1-positive perineurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors. Mod Pathol 2003; 16(4): 293-298.

6. Erlandson RA, Woodruff JM. Peripheral nerve sheath tumors: an electron microscopic study of 43 cases. Cancer 1982; 49(1): 273-287.

7. Hirose T, Sano T, Hizawa K. Ultrastructural localization of S-100 protein in neurofibroma. Acta Neuropathol 1986; 69(1-2): 103-110.

8. Antonescu CR, Scheithauer BW, Woodruff JM. AFIP atlas of tumor pathology (Series 4): Tumors of the peripheral nervous system. Silver Spring, Maryland: ARP Press; 2013.

9. Michal M, Kazakov DV, Hadravský L, Michalový K, Rychlý B, Michal M. Multivacuolated mucin-filled cells: a unique cell characteristic of plexiform neurofibroma. A report of 11 cases. Hum Pathol 2017; 60(2): 167-173.

10. Petrák B, Bendová Š, Lisý J, et al. Neurofibromatosis von Recklinghausen typ 1 (NF1) - klinický obraz a molekulárně-genetická diagnostika. Cesk Patol 2015; 51(1): 34-40.

11. Harder A, Wesemann M, Hagel C, et al. Hybrid neurofibroma/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients. Am J Surg Pathol 2012; 36(5): 702-709.

12. Giannini C, Scheithauer BW, Jenkins RB, et al. Soft-tissue perineurioma. Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol 1997; 21(2): 164-173.

13. Lasota J, Fetsch JF, Wozniak A, Wasag B, Sciot R, Miettinen M. The neurofibromatosis type 2 gene is mutated in perineurial cell tumors: a molecular genetic study of eight cases. Am J Pathol 2001; 158(4): 1223-1229.

14. Stahn V, Nagel I, Fischer-Huchzermeyer S, et al. Molecular Analysis of Hybrid Neurofibroma/Schwannoma Identifies Common Monosomy 22 and alpha-T-Catenin/CTNNA3 as a Novel Candidate Tumor Suppressor. Am J Pathol 2016; 186(12): 3285-3296.

15. Kacerovská D, Michal M, Kuroda N, et al. Hybrid peripheral nerve sheath tumors, including a malignant variant in type 1 neurofibromatosis. Am J Dermatopathol 2013; 35(8): 641-649.

16. Pusiol T, Zorzi MG, Morichetti D, Piscioli F. Routine use of immunohisto-chemistry may increase the frequency of hybrid peripheral nerve sheath tumors. Am J Dermatopathol 2011; 33(8): 634-636.

17. Michal M. Extraneural retiform perineuriomas. A report of four cases. Pathol Res Pract 1999; 195(11): 759-763.

18. Kazakov DV, Piťha J, Šíma R, et al. Hybrid peripheral nerve sheath tumors: Schwannoma-perineurioma and neurofibroma-perineurioma. A report of three cases in extradigital locations. Ann Diagn Pathol 2005; 9(2): 16-23.

19. Kindblom LG, Meis-Kindblom JM, Havel G, Busch C. Benign epithelioid schwannoma. Am J Surg Pathol 1998; 22(6): 762-770.

20. Kacerovská D, Michal M, Kazakov DV. Hybrid Epithelioid Schwannoma/Perineurioma. Am J Dermatopathol. 2016; 38(7): e90-92.

21. Hornick JL, Bundock EA, Fletcher CD. Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol 2009; 33(10): 1554-1561.

22. Hornick JL, Fletcher CD. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol 2005; 29(7): 845-858.

23. Weiss SW, Nickoloff BJ. CD-34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol 1993; 17(10): 1039-1045.

24. McCarron KF, Goldblum JR. Plexiform neurofibroma with and without associated malignant peripheral nerve sheath tumor: a clinicopathologic and immunohistochemical analysis of 54 cases. Mod Pathol 1998; 11(7): 612-617.

25. Rodriguez FJ, Stratakis CA, Evans DG. Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes. Acta Neuropathol 2012; 123(3): 349-367.

26. Shelekhova KV, Danilova AB, Michal M, Kazakov DV. Hybrid neurofibroma-perineurioma: an additional example of an extradigital tumor. Ann Diagn Pathol 2008; 12(6): 233-234.

27. Zámečník M, Michal M. Malignant peripheral nerve sheath tumor with perineurial cell differentiation (malignant perineurioma). Pathol Int 1999; 49(1): 69-73.

28. Hirose T, Sumitomo M, Kudo E, et al. Malignant peripheral nerve sheath tumor (MPNST) showing perineurial cell differentiation. Am J Surg Pathol 1989; 13(7): 613-620.

29. Hirose T, Hasegawa T, Kudo E, Seki K, Sano T, Hizawa K. Malignant peripheral nerve sheath tumors: an immunohistochemical study in relation to ultrastructural features. Hum Pathol 1992; 23(8): 865-870.

30. Agaimy A. Microscopic intraneural perineurial cell proliferations in patients with neurofibromatosis type 1. Ann Diagn Pathol 2014; 18(4): 95-98.

31. Schaefer IM, Strobel P, Thiha A, et al. Soft tissue perineurioma and other unusual tumors in a patient with neurofibromatosis type 1. Int J Clin Exp Pathol 2013; 6(12): 3003-3008.

32. Ausmus GG, Piliang MP, Bergfeld WF, Goldblum JR. Soft-tissue perineurioma in a 20-year-old patient with neurofibromatosis type 1 (NF1): report of a case and review of the literature. J Cutan Pathol 2007; 34(9): 726-730.

33. Zámečník M. Hybrid neurofibroma/schwannoma versus schwannoma with Antoni B areas. Histopathology 2000; 36(5): 473-474.

34. Michal M, Kazakov DV, Belousova I, Bisceglia M, Zamecnik M, Mukensnabl P. A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. Virchows Arch 2004; 445(10): 347-353.

35. Bundock EA FC. Nerve sheath tumors with hybrid features of perineurioma and schwannoma [abstract]. Modern Pathology 2004; 17(suppl 1):12A.

36. Yang X, Zeng Y, Wang J. Hybrid schwannoma/perineurioma: report of 10 Chinese cases supporting a distinctive entity. Int J Surg Pathol 2013; 21(2): 22-28.

37. Emanuel P, Pertsemlidis DS, Gordon R, Xu R. Benign hybrid perineurioma-schwannoma in the colon. A case report. Ann Diagn Pathol 2006; 10(12): 367-370.

38. Agaimy A, Michal M. Hybrid schwannoma-perineurioma of the gastrointestinal tract: a clinicopathologic study of 2 cases and reappraisal of perineurial cells in gastrointestinal schwannomas. Appl Immunohistochem Mol Morphol 2011; 19(10): 454-459.

39. Kuroda N, Kazakov DV, Hes O, et al. Hybrid peripheral nerve sheath tumor of the nasal cavity showing schwannomatous, neurofibromatous, and perineuriomatous areas. Med Mol Morphol 2010; 43(6): 82-85.

40. Rodriguez FJ, Folpe AL, Giannini C, Perry A. Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol 2012; 123(3): 295-319.