Histopatologická diagnostika kožních melanocytárních lézí

Histopathology of skin melanocytic lesions

Melanocytic lesions are instable tumors, the genome of which and its changes determinate their morphology and biological properties. Intermediate lesions share histomorphological features of both, nevi and melanoma. Melanocytomas represent a group of them separated on the basis of recent molecular-biological studies. The article summarizes benign, intermediate, malignant and combined melanocytic skin lesions and offers practical recommendations for diagnosis.

Keywords:

classification – histopathology – melanocytic lesions – genetic alterations – dermoscopy-histopathology correlations – intermediate lesions – melanocytomas – practical recommendations for diagnosis

Autori: Lumír Pock; Alena Skálová
Vyšlo v časopise: Čes.-slov. Patol., 60, 2024, No. 1, p. 12-34
Kategória: Přehledový článek

Súhrn

Melanocytární léze jsou nestabilní tumory, jejichž genom a změny v něm determinují jejich morfologii a biologické vlastnosti. Mezi névy a melanomy jsou v různém smyslu atypické, intermediální léze. Na základě nových molekulárně-biologických poznatků bylo možné v jejich rámci vyčlenit tzv. melanocytomy. Článek poskytuje aktuální souhrn benigních, intermediálních, maligních a kombinovaných melanocytárních kožních lézí a nabízí praktická doporučení při jejich diagnostice.

Klíčová slova:

klasifikace – histopatologie – melanocytární léze – genetické alterace – dermatoskopicko-histopatologické korelace – melanocytomy – praktická diagnostická doporučení – léze intermediální

Zdroje

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