Serological Characteristics of Hantaviruses from Clinical Specimens Analyzed in 1998-2008 in the Department of Virology, Public Health Institute, Ostrava

Česká verzia

Authors: H. Zelená; J. Januška
Authors place of work: Virologické oddělení, Národní referenční laboratoř ČR pro arboviry, Zdravotní ústav se sídlem v Ostravě
Published in the journal: Epidemiol. Mikrobiol. Imunol. 58, 2009, č. 3, s. 115-120

Summary

In 1998 – 2008, serum samples from 464 patients, predominantly residents of the Moravia-Silesian Region, were examined in the Department of Virology, Public Health Institute in Ostrava, using Enzyme-Linked ImmunoSorbent Assay (ELISA) for the detection of specific anti-hantavirus antibodies. Seropositivity was ascertained in 41 persons (8.8 %). More patients tested seropositive against Hantaan virus (24, i.e. 58.5 %) than against Puumala virus (13, i.e. 31.7 %). Four persons were reactive against both antigens. Clinical symptoms corresponding to hantavirus infection were observed in 19 seropositive patients. Fifteen of them had antibodies reactive with Hantaan virus antigen (cross-reactive with anti-Dobrava virus), 3 patients had antibodies against Puumala virus and 1 patient had both types of antibodies. Clinical data on the other seropositive persons were lacking. The higher rate of Dobrava virus infections in the Moravian-Silesian Region seems to be associated, among others, with the geographic distribution of striped field mouse (Apodemus agrarius) which is the main reservoir of Dobrava virus in Central Europe.

Key words:
hantavirus – Dobrava virus – Puumala virus – haemorrhagic fever with renal syndrome – nephropathia epidemica – Apodemus agrarius.

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