Progresivní multifokální leukoencefalopatie – epidemiologie, imunitní odpověď, klinické rozdíly, léčba
Progresivní multifokální leukoencefalopatie – epidemiologie, imunitní odpověď, klinické rozdíly, léčba
Progresivní multifokální leukoencefalopatie (PML) je závažné onemocnění centrální nervové soustavy s velmi vysokou mortalitou. Příčinou onemocnění je JC virus s vysokou séroprevalencí dosahující až 80 %. PML je typické oportunní onemocnění vyskytující se zejména u syndromu získané imunodeficience u pacientů s hlubokým imunodeficitem. Počet případů PML se však v posledních letech zvyšuje také u všeobecné populace jako důsledek vysoce účinných imunosupresivních a imunomodulačních léčebných postupů. V tomto článku autoři uvádějí virologické a epidemiologické souvislosti a charakteristické projevy PML. Jsou diskutovány možné vztahy humorální a buněčné imunity a jsou zmíněny omezené možnosti léčby včetně profylaxe.
Klíčová slova:
buněčná imunita – poměr CD4/CD8 – sclerosis multiplex – progresivní multifokální leukoencefalopatie
Autoři:
S. Snopková 1; P. Štourač 2; L. Fašaneková 1; M. Mihalčin 1; K. Havlíčková 1; R. Svačinka 1; P. Volfová 3; P. Snopek 4; P. Husa 1
Působiště autorů:
Klinika infekčních chorob FN Brno a LF MU, Brno
1; Neurologická klinika FN Brno a LF MU, Brno
2; Interní hematoonkologická klinika FN Brno a LF MU, Brno
3; Fakulta humanitních studií UTB, Zlín
4
Vyšlo v časopise:
Epidemiol. Mikrobiol. Imunol. 68, 2019, č. 1, s. 24-31
Kategorie:
Souhrnné sdělení
Souhrn
Progresivní multifokální leukoencefalopatie (PML) je závažné onemocnění centrální nervové soustavy s velmi vysokou mortalitou. Příčinou onemocnění je JC virus s vysokou séroprevalencí dosahující až 80 %. PML je typické oportunní onemocnění vyskytující se zejména u syndromu získané imunodeficience u pacientů s hlubokým imunodeficitem. Počet případů PML se však v posledních letech zvyšuje také u všeobecné populace jako důsledek vysoce účinných imunosupresivních a imunomodulačních léčebných postupů. V tomto článku autoři uvádějí virologické a epidemiologické souvislosti a charakteristické projevy PML. Jsou diskutovány možné vztahy humorální a buněčné imunity a jsou zmíněny omezené možnosti léčby včetně profylaxe.
Klíčová slova:
buněčná imunita – poměr CD4/CD8 – sclerosis multiplex – progresivní multifokální leukoencefalopatie
Zdroje
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Štítky
Hygiena a epidemiológia Infekčné lekárstvo MikrobiológiaČlánok vyšiel v časopise
Epidemiologie, mikrobiologie, imunologie
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