DPP-4-inhibitors – What are the similarities, where are the differences?

Česká verzia

Authors: Matthias Blüher
Authors place of work: Lekárska fakulta, Lipská univerzita, Lipsko, Nemecko, a Univerzitná nemocnica Lipsko, III. interná klinika, oddelenie endokrinológie a nefrológie, Lipsko, Nemecko
Published in the journal: Forum Diab 2012; 1(1): 9-16
Category: Hlavná téma

Summary

With the increasing prevalence of type 2 diabetes and its complications throughout the world, there is a need for efficient and safe therapeutic strategies. The dipeptidyl peptidase-4 (DPP-4) inhibitors have become important oral glucose lowering drugs for the management of patients with type 2 diabetes. All DPP-4-inhibitors act on the incretin system to lower hyperglycemia, have a similar safety profile, are well tolerated, do not cause significant weight gain and have a relatively low risk of hypoglycemia. However, there are clinical differences among the four agents, sitagliptin, vildagliptin, saxagliptin, and linagliptin which are currently approved by the US Food and Drug Administration or the European Medicines Agency. This review article discusses similarities and differences in efficacy, safety and tolerability of these four DPP-4-inhibitors.

Key words:
DPP-4-inhibitors – vildagliptin – sitagliptin – saxagliptin – linagliptin – type 2 diabetes – incretin system – GLP-1

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