Problems of measuring PTH in following chronic renal disease: A minireview.

Česká verzia

Authors: J. Vávrová; B. Friedecký; L. Pavlíková
Authors place of work: Ústav klinické biochemie a diagnostiky, Fakultní nemocnice, Hradec Králové
Published in the journal: Klin. Biochem. Metab., 23 (44), 2015, No. 1, p. 5-8

Summary

Method:
Overview of recent literature on the PTH comparability from 2009-2014. Comparison of PTH results obtained from 99 patients on the hemodialysis during their regular controls. We used for this purpose three methods of 2^nd generation (DiaSorin, Roche, Siemens DPC) and two methods of 3^th generation (DiaSorin, Roche).

Results and discussion:
Results obtained by different methods are not comparable. Median values are two times or more (in higher concentrations) different between results obtained by 2^nd or 3^th generation of methods. Differences between methods of the same generation are also significant. Number of patients on the hemodialysis with values in required interval of decision limits according to KDIGO 2009 was strongly dependent on the used method and maximum of these differences was approximately 250%. In our opinion is introducing the 3^th generation methods of measurement PTH first step to improving the use of PTH in chronic renal diseased patients. Definitive step to rational use of PTH measurement is standardization.

Keywords:
PTH, 2^nd and 3^th generation of methods, hemodialysis, comparability, standardization.

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