Metabolismus bilirubinu a jeho biologické účinky

Článek se zabývá molekulou bilirubinu a jejími důležitými biologickými vlastnostmi. Bilirubin byl dlouhou dobu vnímán pouze jako odpadní produkt katabolismu hemu s potenciálně toxickými účinky zejména na centrální nervový systém. Dnes je však bilirubin v centru pozornosti vědců díky svým protektivním účinkům. Mírně zvýšené plazmatické koncentrace bilirubinu vykazují antioxidační, protizánětlivé a imunomodulační účinky, které byly pozorovány zvláště u pacientů s onemocněními souvisejícími s oxidačním stresem a chronickými záněty. Přesné mechanismy protektivního působení bilirubinu nejsou stále plně objasněny a jsou předmětem intenzivního výzkumu, přitom porozumění těmto mechanismům by mohlo pomoci terapeutickému využití látek mírně zvyšujících systémové koncentrace bilirubinu.

Klíčová slova:
bilirubin, oxidační stres, zánět, antioxidační působení.

Autoři: P. Valášková; L. Muchová
Působiště autorů: General University Hospital in Prague, Czech Republic ; Laboratory for Research of Liver Diseases and Heme Metabolism, Central Research Laboratories, Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and
Vyšlo v časopise: Klin. Biochem. Metab., 24, 2016, No. 4, p. 198-202

Souhrn

Klíčová slova:
bilirubin, oxidační stres, zánět, antioxidační působení.

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