Hormonal Contraceptives and Their Relationship to Breast Cancer

Česká verzia

Authors: M. Habánová ¹; J. Švikruhová ¹; E. Sláviková ²
Authors place of work: Katedra výživy ľudí, Slovenská poľnohospodárska univerzita v Nitre, Slovenská Republika ¹; Medicinske centrum, Nitra, Slovenská Republika ²
Published in the journal: Klin Onkol 2010; 23(6): 428-432
Category: Původní práce

Summary

Backgrounds:
The incidence of breast cancer diseases is continuously increasing. Hormonal factors like menarche, menopause and hormone replacement therapy are contributing to breast cancer cases.

Patients and Methods:
Within the retrospective study we monitored one hundred patients between 28 and 79 years old, selected randomly with positive anamnesis of malignant breast cancer. Based on an analysis of their health records, we tried to identify the effect of the risk of hormonal therapy on breast cancer occurrence. The age of patients at which the disease was diagnosed and the length of hormonal treatment were monitored as well.

Results:
Of the one hundred randomly selected patients diagnosed with breast cancer, the majority with positive anamnesis of breast cancer were between 40 and 59 years old. 69 of them have never used any hormonal treatment. The average age of cancer detection in the focused group was 53.38 years old. It was discovered that hormonal contraceptives (HC) and hormone replacement therapy (HRT) decreases the age when breast cancer was first diagnosed. The average age of patients with breast cancer who used HC (n = 16) was 51.80 years old and the average age of patients who used HRT (n = 15) was 51.25 years old.

Conclusion:
Although the age at which patients are diagnosed with breast cancer (being treated with HC and HRT) is lower than the age at which patients were positively diagnosed without using any hormonal treatment, the difference is statistically insignificant.

Key words:
breast neoplasms – contraception – hormone replacement therapy – risk factors

Zdroje

1. Strnad P, Daneš J. Nemoci prsu pro gynekology. Praha: Grada Publishing 2001: 324.

2. Bray F, Sankila R, Ferlay J et al. Estimates of cancer incidence and mortality in Europe in 1995. Eur J Canc 2002; 38: 99– 165.

3. Valovičová E. Rakovina prsníka – čo o nej vieme? Podpora zdravia 1999; 3: 2– 4.

4. Novák J, Palácová M, Foretová L et al. Zhoubná nádorová onemocnení v České Republice 1989– 2004. Klin Onkol 2008; 21(1): 35– 36.

5. Giacosa A, Filiberty R. Free radicals, oxidative damage and degenerative diseases. Eur J Cancer Prev 1996; 5(5): 307– 312.

6. Enger SM, Ross RK, Henderson B et al. Breastfeeding history, pregnancy experience and breast cancer. Br J Cancer 1997; 76(1): 11– 14.

7. Mishell D. Breast Cancer Risk use of Combined Oral Contraceptives. Contraception 1996; 54(3): 24– 29.

8. Minarovič I. Riziko rakoviny prsníka pri kombinácii estrogén – progestin vyššie než pri estrogéne samotnom. Lekárnicke listy 2000; 2(5): 21.

9. Casey PM, Cerhan JR, Pruthi S. Oral Contraceptive Use and the Risk of Breast Cancer. Mayo Clin Proc 2008; 83(1): 86– 91.

10. Kolláriková E. Antikoncepcia a rakovina prsníka. Zdravie 2003; 53(3): 72– 73.

11. Kuzma I. Rakovina prsníka. 4. vyd. Bratislava: Liga proti rakovine SR 2001.

12. McTaggart L. The cancer handbook – Wat’s really workong. 1. vyd. Philadelphia: JAMA 2002: 28.

13. Nižňanská Z. Nízkodávková kombinovaná hormonálna antikoncepcia. Gynekológia pre prax 2003; 1(1): 45– 50.

14. Borovský M, Sojáková M. Hormonálna substitučná liečba a gynekologické nádorové ochoreia. Iatrike Techne 2002; 12(7): 28– 32.

15. Fait T. Hormonální substituční terapie a riziko karcinomu prsu. Iatrike Techne 2002; 7(2): 38– 41.

16. McPherson K, Steel CM, Dixon JM. Breast cancer‑ epidemiology, risk factors and genetics. BMJ 2000; 321(7261): 624– 628.

17. Sharier C, Gail M, Bryne C et al. Estrogen replacement therapy and breast cancer surrival in a large screening study. J Natl Vancer Inst 1999; 91(3): 264– 270.

18. Svobodník A, Abrahámová J, Kubala E et al. Predikce rizika vzniku karcinomu prsu u žen v České Republice – metodika sběru dat pro validaci matematického prediktivního modelu. Klin Onkol 2001; 14(4): 135– 141.