Epistasis and Entropy

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Some recent approaches for identifying epistasis from sequence data depend on information theory. We show that considering shared entropy for pairs of loci can be misleading. The reason is that shared entropy does not imply epistasis for the pair. This observation holds true also in the absence of higher order epistasis. We discuss a method for reducing the number of false positives in the proposed method. However, our main conclusion is that shared entropy for pairs of loci is difficult to interpret. Gene frequencies reflect interactions in the entire system, and there is no natural way to decompose frequency data.

Vyšlo v časopise: Epistasis and Entropy. PLoS Genet 12(12): e32767. doi:10.1371/journal.pgen.1006322
Kategorie: Formal Comment
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1006322

Souhrn

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