CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy

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In the mammary gland, genetic circuits controlled by the hormones, estrogen, progesterone and prolactin, act in concert with pathways regulated by members of the epidermal growth factor family to orchestrate growth and morphogenesis during puberty, pregnancy and lactation. We have identified CUZD1 as a novel mediator of prolactin signaling in the steroid hormone-primed mouse mammary gland during pregnancy and lactation. Cuzd1-null mice exhibited a striking impairment in ductal branching and alveolar development during pregnancy, resulting in a subsequent defect in lactation. Administration of prolactin failed to induce proliferation of the mammary epithelium in Cuzd1-null mice. Protein binding studies revealed that CUZD1 interacts with downstream transducers of prolactin signaling, JAK1/JAK2 and STAT5. Additionally, elevated expression of Cuzd1 in mammary epithelial cells stimulated phosphorylation and nuclear translocation of STAT5. CUZD1, therefore, is a critical mediator of prolactin that controls mammary alveolar development.

Vyšlo v časopise: CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy. PLoS Genet 13(3): e32767. doi:10.1371/journal.pgen.1006654
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1006654

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