Antiretroviral Strategies to Prevent Mother-to-Child Transmission of HIV: Striking a Balance between Efficacy, Feasibility, and Resistance

1. World Health Organization 2006 Antiretroviral drugs for treating pregnant women and preventing HIV infection in infant: towards universal access. Recommendations for a public health approach. Available: http://www.who.int/hiv/pub/guidelines/pmtctguidelines3.pdf. Accessed 4 September 2009

2. GuayLA

MusokeP

FlemingT

BagendaD

AllenM

1999 Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 354 795 802

3. ArriveE

DabisF

2008 Prophylactic antiretroviral regimens for prevention of mother-to-child transmission of HIV in resource-limited settings. Curr Opin HIV AIDS 3 161 165

4. JourdainG

Ngo-Giang-HuongN

Le CoeurS

BowonwatanuwongC

KantipongP

2004 Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy. N Engl J Med 351 229 240

5. LockmanS

ShapiroRL

SmeatonLM

WesterC

ThiorI

2007 Response to antiretroviral therapy after a single, peripartum dose of nevirapine. N Engl J Med 356 135 147

6. LockmanS

2008 Prevention of mother-to-child transmission, drug resistance, and implications for response to therapy. Curr Opin HIV AIDS 3 166 172

7. DaoH

MofensonLM

EkpiniR

GilksCF

BarnhartM

2007 International recommendations on antiretroviral drugs for treatment of HIV-infected women and prevention of mother-to-child HIV transmission in resource-limited settings: 2006 update. Am J Obstet Gynecol 197 S42 S55

8. World Health Organization, UNAIDS, Unicef 2008 Towards universal access. Scaling up priority HIV/AIDS interventions in the health sector. Available: http://www.who.int/hiv/pub/2008progressreport/en/. Accessed 4 September 2009

9. KilewoC

KarlssonK

NgarinaM

MassaweA

LyamuyaE

2009 Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus Study. J Acquir Immune Defic Syndr In press

10. LehmanDA

ChungMH

MabukaJM

John-StewartGC

KiarieJ

2009 Lower risk of resistance after short-course HAART compared with zidovudine/single-dose nevirapine used for prevention of HIV-1 mother-to-child transmission. J Acquir Immune Defic Syndr 51 522 529

11. EshlemanSH

HooverDR

HudelsonSE

ChenS

FiscusSA

2006 Development of nevirapine resistance in infants is reduced by use of infant-only single-dose nevirapine plus zidovudine postexposure prophylaxis for the prevention of mother-to-child transmission of HIV-1. J Infect Dis 193 479 481

12. McIntyreJA

HopleyM

MoodleyD

EklundM

GrayGE

2009 Efficacy of short-course AZT+3TC to reduce nevirapine resistance in the prevention of mother-to-child HIV transmission. PLoS Med 6 e1000172 doi:10.1371/journal.pmed.1000172

13. McIntyreJ

MartinsonN

GrayG

HopleyM

KimuraT

2005 Addition of short course Combivir (CBV) to single dose Viramune (sdNVP) for the prevention of mother to child transmission (pMTCT) of HIV-1 can significantly decrease the subsequent development of maternal and paediatric NNRTI-resistant virus TuFo0204. In: Proceedings of the 3rd International Aids Society Conference on HIV Pathogenesis and Treatment; 24–27 July, 2005; Rio de Janeiro, Brazil. Available: http://www.iasociety.org/Default.aspx?pageId=11&abstractId=2176901. Accessed 4 September 2009

14. ChaixML

EkoueviDK

RouetF

Tonwe-GoldB

VihoI

2006 Low risk of nevirapine resistance mutations in the prevention of mother-to-child transmission of HIV-1: Agence Nationale de Recherches sur le SIDA Ditrame Plus, Abidjan, Cote d'Ivoire. J Infect Dis 193 482 487

15. ChiBH

SinkalaM

MbeweF

CantrellRA

KruseG

2007 Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial. Lancet 370 1698 1705