Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis
In this study, James Brenton and colleagues demonstrate that quantitative measures of intratumoural heterogeneity may have predictive value for survival after chemotherapy treatment in high-grade serous ovarian cancer.
Vyšlo v časopise:
Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis. PLoS Med 12(2): e32767. doi:10.1371/journal.pmed.1001789
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pmed.1001789
Souhrn
In this study, James Brenton and colleagues demonstrate that quantitative measures of intratumoural heterogeneity may have predictive value for survival after chemotherapy treatment in high-grade serous ovarian cancer.
Zdroje
1. Nowell PC (1976) The clonal evolution of tumor cell populations. Science 194: 23–28. 959840
2. Dexter DL, Kowalski HM, Blazar BA, Fligiel Z, Vogel R, et al. (1978) Heterogeneity of tumor cells from a single mouse mammary tumor. Cancer Res 38: 3174–3181. 210930
3. Khalique L, Ayhan A, Weale ME, Jacobs IJ, Ramus SJ, et al. (2007) Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours. J Pathol 211: 286–295. 17154249
4. Khalique L, Ayhan A, Whittaker JC, Singh N, Jacobs IJ, et al. (2009) The clonal evolution of metastases from primary serous epithelial ovarian cancers. Int J Cancer 124: 1579–1586. doi: 10.1002/ijc.24148 19123469
5. Shah SP, Morin RD, Khattra J, Prentice L, Pugh T, et al. (2009) Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461: 809–813. doi: 10.1038/nature08489 19812674
6. Navin N, Krasnitz A, Rodgers L, Cook K, Meth J, et al. (2010) Inferring tumor progression from genomic heterogeneity. Genome Res 20: 68–80. doi: 10.1101/gr.099622.109 19903760
7. Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, et al. (2010) The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467: 1109–1113. doi: 10.1038/nature09460 20981101
8. Navin N, Kendall J, Troge J, Andrews P, Rodgers L, et al. (2011) Tumour evolution inferred by single-cell sequencing. Nature 472: 90–94. doi: 10.1038/nature09807 21399628
9. Marusyk A, Almendro V, Polyak K (2012) Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 12: 323–334. doi: 10.1038/nrc3261 22513401
10. Vermaat JS, Nijman IJ, Koudijs MJ, Gerritse FL, Scherer SJ, et al. (2012) Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. Clin Cancer Res 18: 688–699. doi: 10.1158/1078-0432.CCR-11-1965 22173549
11. Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJH, et al. (2012) Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 482: 529–533. doi: 10.1038/nature10825 22343890
12. Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, et al. (2012) Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366: 883–892. doi: 10.1056/NEJMoa1113205 22397650
13. Shah SP, Roth A, Goya R, Oloumi A, Ha G, et al. (2012) The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 486: 395–399. doi: 10.1038/nature10933 22495314
14. de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC, et al. (2014) Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 346: 251–256. doi: 10.1126/science.1253462 25301630
15. Nik-Zainal S, Van Loo P, Wedge DC, Alexandrov LB, Greenman CD, et al. (2012) The life history of 21 breast cancers. Cell 149: 994–1007. doi: 10.1016/j.cell.2012.04.023 22608083
16. Merlo LMF, Pepper JW, Reid BJ, Maley CC (2006) Cancer as an evolutionary and ecological process. Nat Rev Cancer 6: 924–935. 17109012
17. Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481: 306–313. doi: 10.1038/nature10762 22258609
18. Anderson K, Lutz C, van Delft FW, Bateman CM, Guo Y, et al. (2011) Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 469: 356–361. doi: 10.1038/nature09650 21160474
19. Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, et al. (2013) Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 152: 714–726. doi: 10.1016/j.cell.2013.01.019 23415222
20. Ahmed AA, Etemadmoghadam D, Temple J, Lynch AG, Riad M, et al. (2010) Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. J Pathol 221: 49–56. doi: 10.1002/path.2696 20229506
21. Gorringe KL, Jacobs S, Thompson ER, Sridhar A, Qiu W, et al. (2007) High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications. Clin Cancer Res 13: 4731–4739. 17699850
22. Cancer Genome Atlas Research Network (2011) Integrated genomic analyses of ovarian carcinoma. Nature 474: 609–615. doi: 10.1038/nature10166 21720365
23. Sangha N, Wu R, Kuick R, Powers S, Mu D, et al. (2008) Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations. Neoplasia 10: 1362–1372. 19048115
24. Carter SL, Cibulskis K, Helman E, McKenna A, Shen H, et al. (2012) Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol 30: 413–421. doi: 10.1038/nbt.2203 22544022
25. Bashashati A, Ha G, Tone A, Ding J, Prentice LM, et al. (2013) Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling. J Pathol 231: 21–34. doi: 10.1002/path.4230 23780408
26. Zhang J, Shi Y, Lalonde E, Li L, Cavallone L, et al. (2013) Exome profiling of primary, metastatic and recurrent ovarian carcinomas in a BRCA1-positive patient. BMC Cancer 13: 146. doi: 10.1186/1471-2407-13-146 23522120
27. Hoogstraat M, de Pagter MS, Cirkel GA, van Roosmalen MJ, Harkins TT, et al. (2014) Genomic and transcriptomic plasticity in treatment-naive ovarian cancer. Genome Res 24: 200–211. doi: 10.1101/gr.161026.113 24221193
28. Cooke SL, Ng CKY, Melnyk N, Garcia MJ, Hardcastle T, et al. (2010) Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma. Oncogene 29: 4905–4913. doi: 10.1038/onc.2010.245 20581869
29. Cooke SL, Brenton JD (2011) Evolution of platinum resistance in high-grade serous ovarian cancer. Lancet Oncol 12: 1169–1174. doi: 10.1016/S1470-2045(11)70123-1 21742554
30. Wang ZC, Birkbak NJ, Culhane AC, Drapkin R, Fatima A, et al. (2012) Profiles of genomic in-stability in high-grade serous ovarian cancer predict treatment outcome. Clin Cancer Res 18: 5806–5815. doi: 10.1158/1078-0432.CCR-12-0857 22912389
31. Cowin PA, George J, Fereday S, Loehrer E, Van Loo P, et al. (2012) LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin. Cancer Res 72: 4060–4073. 22896685
32. Schwarz RF, Trinh A, Sipos B, Brenton JD, Goldman N, et al. (2014) Phylogenetic quantification of intra-tumour heterogeneity. PLoS Comput Biol 10: e1003535. doi: 10.1371/journal.pcbi.1003535 24743184
33. Greenman CD, Bignell G, Butler A, Edkins S, Hinton J, et al. (2010) PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data. Biostatistics 11: 164–175. doi: 10.1093/biostatistics/kxp045 19837654
34. Ng CKY, Cooke SL, Howe K, Newman S, Xian J, et al. (2012) The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer. J Pathol 226: 703–712. doi: 10.1002/path.3980 22183581
35. Li H, Durbin R (2009) Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25: 1754–1760. doi: 10.1093/bioinformatics/btp324 19451168
36. Untergasser A, Cutcutache I, Koressaar T, Ye J, Faircloth BC, et al. (2012) Primer3—new capabilities and interfaces. Nucleic Acids Res 40: e115. 22730293
37. Forshew T, Murtaza M, Parkinson C, Gale D, Tsui DWY, et al. (2012) Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med 4: 136ra68. doi: 10.1126/scitranslmed.3003726 22649089
38. Robinson JT, Thorvaldsdóttir H, Winckler W, Guttman M, Lander ES, et al. (2011) Integrative genomics viewer. Nat Biotechnol 29: 24–26. doi: 10.1038/nbt.1754 21221095
39. Archibald KM, Kulbe H, Kwong J, Chakravarty P, Temple J, et al. (2012) Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium. Oncogene 31: 4987–4995. doi: 10.1038/onc.2011.653 22266861
40. Sala E, Kataoka MY, Priest AN, Gill AB, McLean MA, et al. (2012) Advanced ovarian cancer: mul-tiparametric MR imaging demonstrates response-and metastasis-specific effects. Radiology 263: 149–159. doi: 10.1148/radiol.11110175 22332064
41. McBride DJ, Etemadmoghadam D, Cooke SL, Alsop K, George J, et al. (2012) Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes. J Pathol 227: 446–455. doi: 10.1002/path.4042 22514011
42. Bryant D, Moulton V (2004) Neighbor-net: an agglomerative method for the construction of phylogenetic networks. Mol Biol Evol 21: 255–265. 14660700
43. Castellarin M, Milne K, Zeng T, Tse K, Mayo M, et al. (2012) Clonal evolution of high-grade serous ovarian carcinoma from primary to recurrent disease. J Pathol 229: 515–524. doi: 10.1002/path.4105 22996961
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