Population Genetic Analyses Reveal the African Origin and Strain Variation of var.

1. LinXHeitmanJ 2006 The biology of the Cryptococcus neoformans species Complex. Annu Rev Microbiol 60 69 105

2. MaHMayRC 2009 Virulence in Cryptococcus species. Adv Appl Microbiol 67 131 190

3. PerfectJRDismukesWEDromerFGoldmanDLGraybillJR 2010 Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 50 291 322

4. ParkBJWannemuehlerKAMarstonBJGovenderNPappasPG 2009 Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23 525 530

5. ChenJVarmaADiazMRLitvintsevaAPWollenbergKK 2008 Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China. Emerg Infect Dis 14 755 762

6. LengelerKCoxGHeitmanJ 2001 Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and heterozygous at the mating-type locus. Infect Immun 69 115 122

7. LitvintsevaAPLinXTempletonIHeitmanJMitchellTG 2007 Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa. PLoS Pathog 3 e114 doi:10.1371/journal.ppat.0030114

8. XuJLuoGVilgalysRJBrandtMEMitchellTG 2002 Multiple origins of hybrid strains of Cryptococcus neoformans with serotype AD. Microbiology 148 203 212

9. GovenderNMitchellTGlitvintsevaAPMigliaKJ 2011 Cryptococcosis in Africa. HeitmanJKozelTRKwon-ChungJPerfectJRCasadevallA Cryptococcus: from human pathogen to model yeast Washington (D.C.) ASM Press 269 285

10. LitvintsevaAPKestenbaumLVilgalysRMitchellTG 2005 Comparative analysis of environmental and clinical populations of Cryptococcus neoformans. J Clin Microbiol 43 556 564

11. XuJManosuthiWBanerjeeUZhuL-PChenJ 2011 Cryptococcosis in Asia. HeitmanJKozelTRKwon-ChungJPerfectJRCasadevallA Cryptococcus from human pathogen to model yeast Washington (D.C.) ASM Press 287 298

12. BoversMHagenFKuramaeEEBoekhoutT 2008 Six monophyletic lineages identified within Cryptococcus neoformans and Cryptococcus gattii by multi-locus sequence typing. Fungal Genet Biol 45 400 421

13. LitvintsevaAPThakurRVilgalysRMitchellTG 2006 Multilocus sequence typing reveals three genetic subpopulations of Cryptococcus neoformans var. grubii (serotype A), including a unique population in Botswana. Genetics 172 2223 2238

14. LitvintsevaAPCarboneIRossouwJThakurRGovenderNP 2011 Evidence that the human pathogenic fungus Cryptococcus neoformans var. grubii may have evolved in Africa. PLoS ONE 6 e19688 doi:10.1371/journal.pone.0019688

15. SimwamiSPKhayhanKHenkDAAanensenDMBoekhoutT 2011 Low diversity Cryptococcus neoformans variety grubii multilocus sequence types from Thailand are consistent with an ancestral African origin. PLoS Pathog 7 e1001343 doi:10.1371/journal.ppat.1001343

16. ChoiYHNgamskulrungrojPVarmaASionovEHwangSM 2010 Prevalence of the VNIc genotype of Cryptococcus neoformans in non-HIV-associated cryptococcosis in the Republic of Korea. FEMS Yeast Res 10 769 778

17. LitvintsevaAPMarraRENielsenKHeitmanJVilgalysR 2003 Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa. Eukaryot Cell 2 1162 1168

18. LongJL 1981 Introduced birds of the world: the worldwide history, distribution and influence of birds introduced to new environments London David & Charles 208 211

19. GrzimekBSchlagerNOlendorfD 2004 Pigeons and doves. McDadeMC Grzimek's animal life encyclopedia. Volume 9: Birds II Detroit Gale 247 268

20. KronstadJWAttarianRCadieuxBChoiJD'SouzaCA 2011 Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box. Nat Rev Microbiol 9 193 203

21. KumarPYangMHaynesBCSkowyraMLDoeringTL 2011 Emerging themes in cryptococcal capsule synthesis. Curr Opin Struct Biol 21 597 602

22. LiawSJWuHCHsuehPR 2010 Microbiological characteristics of clinical isolates of Cryptococcus neoformans in Taiwan: serotypes, mating types, molecular types, virulence factors, and antifungal susceptibility. Clin Microbiol Infect 16 696 703

23. MitchellTGLitvintsevaAP 2010 Typing species of Cryptococcus and epidemiology of cryptococcosis. AshbeeHRBignellEM Pathogenic yeasts Berlin Heidelberg Springer-Verlag 167 190

24. PedrosoRSLavradorMAFerreiraJCCandidoRCMaffeiCM 2010 Cryptococcus neoformans var. grubii - pathogenicity of environmental isolates correlated to virulence factors, susceptibility to fluconazole and molecular profile. Mem Inst Oswaldo Cruz 105 993 1000

25. AlanioADesnos-OllivierMDromerF 2011 Dynamics of Cryptococcus neoformans-macrophage interactions reveal that fungal background influences outcome during cryptococcal meningoencephalitis in humans. mBio 2 e00158 11

26. MigliaKJGovenderNPRossouwJMeiringSMitchellTG 2011 Analyses of pediatric isolates of Cryptococcus neoformans from South Africa. J Clin Microbiol 49 307 314

27. LitvintsevaAPMitchellTG 2009 Most environmental isolates of Cryptococcus neoformans var. grubii (serotype A) are not lethal for mice. Infect Immun 77 3188 3195

28. Illnait-ZaragoziMTMartinez-MachinGFFernandez-AndreuCMBoekhoutTMeisJF 2010 Microsatellite typing of clinical and environmental Cryptococcus neoformans var. grubii isolates from Cuba shows multiple genetic lineages. PLoS ONE 5 e9124 doi:10.1371/journal.pone.0009124