Antibiotic therapy in the treatment of skin abscess − meta-analysis
Authors:
A. Kotlářová 1; M. Molitor 2; P. Christodoulou 2; O. Měšťák 2
Authors place of work:
Chirurgická klinika 2. lékařská fakulty Univerzity Karlovy a Fakultní nemocnice Motol, Praha
1; Klinika plastické chirurgie, Nemocnice Na Bulovce, Praha
2
Published in the journal:
Rozhl. Chir., 2021, roč. 100, č. 7, s. 325-329.
Category:
Souhrnné sdělení
doi:
https://doi.org/10.33699/PIS.2021.100.7.325–329
Summary
Skin abscess is one of the most common infections of skin and soft tissues. Incision and drainage under local anesthesia is the mainstay of treatment. Although previous small-scale studies failed to show a benefit of antibiotics in patients with simple abscesses, the use of antibiotic therapy is still encountered in the treatment of uncomplicated skin abscesses in our practice. The purpose of our study was to evaluate existing data assessing the effect of adjuvant antibiotic therapy on abscess management. Although as indicated by two recent multicenter studies, antibiotics may provide a positive effect in the management, it is important to consider the risk of resistance associated with antibiotic overuse and to approach each case individually.
Keywords:
abscess − skin infection − soft tissue infection – antibiotics − incision and drainage – abscess – skin infection – soft tissue infection – antibiotics – incision and drainage
Zdroje
- Galli L, Venturini E, Bassi A, et al. Common community-acquired bacterial skin and soft-tissue infections in children: an intersociety consensus on impetigo, abscess, and cellulitis treatment. Clin Ther. 2019;41(3):532−551.e17. doi:10.1016/j.clinthera.2019.01.010.
- Vermandere M, Aertgeerts B, Agoritsas T, et al. Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline. BMJ 2018;360:k243. doi:10.1136/bmj.
- Singer AJ, Thode HC Jr. Systemic antibiotics after incision and drainage of simple abscesses: a meta-analysis. Emerg Med J. 2014;31(7):576−578. doi:10.1136/emermed-2013-202571.
- Rajendran PM, Young D, Maurer T, et al. Randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk for community-acquired methicillin-resistant Staphylococcus aureus infection. Antimicrob Agents Chemother. 2007;51(11):4044−4048. doi:10.1128/AAC.00377-07.
- Schmitz GR, Bruner D, Pitotti R, et al. Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection. Ann Emerg Med. 2010;56(3):283−287. doi:10.1016/j.annemergmed.2010.03.002.
- Llera JL, Levy RC. Treatment of cutaneous abscess: a double-blind clinical study. Ann Emerg Med. 1985;14(1):15−19. doi:10.1016/s0196-0644(85)80727-7.
- Duong M, Markwell S, Peter J, et al. Randomized, controlled trial of antibiotics in the management of community-acquired skin abscesses in the pediatric patient. Ann Emerg Med. 2010;55(5):401−407. doi:10.1016/j.annemergmed.2009.03.014.
- Fahimi J, Singh A, Frazee B. The role of adjunctive antibiotics in the treatment of skin and soft tissue abscesses: A systematic review and meta-analysis. CJEM 2015;17(4):420−432. doi:10.1017/cem.2014.52.
- Moran GJ, Krishnadasan A, Gorwitz RJ. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006;355:666–674. doi: 10.1056/NEJMoa055356.
- Frazee B. Antibiotics for simple skin abscesses: the new evidence in perspective. Emerg Med J. 2018;35(4):277−278. doi:10.1136/emermed-2017-207323.
- Talan DA, Mower WR, Krishnadasan A, et al. Trimethoprim-sulfamethoxazole versus placebo for uncomplicated skin abscess. N Engl J Med. 2016;374: 823–832.doi: 10.1056/NEJMoa1507476.
- Daum RS, Miller LG, Immergluck L, et al. A placebo controlled trial of antibiotics for smaller skin abscesses. N Engl J Med. 2017;376:2545−2555. doi: 10.1056/NEJMoa1607033 (2017).
- Stevens DL, Bisno AL, et al. Executive summary: Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases 2014;59(2):147–159. doi:org/10.1093/cid/ciu444.
- Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. World Health Organization [online]. Geneva 2017. [cit. 2020-11-08]. Available at: https://www.who.int/medicines/publications/global-priority-list-antibiotic-resistant-bacteria/en/.
Štítky
Chirurgia všeobecná Ortopédia Urgentná medicínaČlánok vyšiel v časopise
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