Vliv glukokortikoidového receptoru na hyperpyrexii navozenou metamfetaminem

Byl zkoumán vliv glukokortikoidu na metamfetaminem (MA) navozenou hyperpyrexii

s užitím bio-telemetrického systému. Prokazatelná úroveň hyperpyrexie byla pozorována u krys, kterým byl podáván MA. Naproti tomu vzestup tělesné teploty byl potlačen adrenalektomií nebo podáváním RU-486, tj. antagonisty glukokortikoidového receptoru. Tyto údaje nasvědčují, že glukokortokoidový receptor může být odpovědný za hyperpyrexii navozenou metamfetaminem.

Klíčová slova:
metamfetamin – hyperpyrexie – glukokortikoidy – kortikosteron

Autoři: S. Yoshida ¹; H. Kinoshita ²; T. Tatara ¹; C. Tashiro ¹; M. Nishiguchi ³; H. Ouchi ³; T. Minami ³; S. Hishida ³
Působiště autorů: Department of Anesthesia, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 66 -8501, Japan ¹; Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki, Kita, Kagawa, 761-079 , Japan ²; Department of Legal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan ³
Vyšlo v časopise: Soud Lék., 57, 2012, No. 4, p. 66-68
Kategorie: Původní práce

Souhrn

Klíčová slova:
metamfetamin – hyperpyrexie – glukokortikoidy – kortikosteron

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